Results 61 to 70 of about 188,278 (265)

The physical, chemical, and microbiological stability of chloramphenicol ophthalmic solution

Libyan International Medical University Journal, 2018
Aims: The aim of this work is to “predict” the remaining shelf-life of chloramphenicol (CH) eye drops, commercially marketed, using the theoretical “Longland–Rowbotham model,”” followed by confirmation of findings by practical means.
Tauwfik Salih, Idris El-Mahdi
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cytoplasmic male sterility in Russian dandelion

, 2015
Russian dandelion (Taraxacum kok-saghyz) is a candidate species for introducing natural rubber production into North America, and its domestication is currently underway to create an economically viable crop.
Wolyn, David J., Hodgson-Kratky, Katrina J. M.   +1 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Onion Male Sterility: Genetics, Genomics and Breeding [PDF]

Onion, belonging to the Allium genus, is an essential and versatile vegetable crop that plays a pivotal role in culinary traditions worldwide. Renowned for its distinctive flavor and nutritional value, onion is an indispensable ingredient in countless ...
Hela Chikh-Rouhou, Singh, Saurabh, Srija Priyadarsini, Chikh-Rouhou, Hela, Saurabh Singh, Priyadarsini, Srija, Cristina Mallor, Mallor, Cristina   +7 more
core   +1 more source

Role Prdm9 v modelu hybridní sterility myši domácí [PDF]

, 2023
(česky) Hybridní sterilita je fenomén představující reprodukční izolaci mezi blízce příbuznými druhy a tím zajištění procesu speciace. Hybridní sterilita je komplexní polygenní znak a nejvýznamnějšího pokroku v jejím studiu je dosaženo u Drosophila ...
Mukaj, Amisa
core  

Interspecies Hybridisation and Genome Chimerisation in Saccharomyces: Combining of Gene Pools of Species and Its Biotechnological Perspectives

Frontiers in Microbiology, 2018
Over the last one and a half decade, interspecies hybridisation has gained continuously increasing attention as a breeding technique suitable for transferring of genetic information between Saccharomyces species and mixing of their gene pools without ...
Matthias Sipiczki
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A systematic map of studies testing the relationship between temperature and animal reproduction

Ecological Solutions and Evidence
Exposure to extreme temperatures can negatively affect animal reproduction, by disrupting the ability of individuals to produce any offspring (fertility), or the number of offspring produced by fertile individuals (fecundity).
Liam R. Dougherty, Fay Frost, Maarit I. Maenpaa, Melissah Rowe, Benjamin J. Cole, Ramakrishnan Vasudeva, Patrice Pottier, Eva Schultner, Erin L. Macartney, Ina Lindenbaum, Jamie L. Smith, Pau Carazo, Marco Graziano, Hester Weaving, Berta Canal Domenech, David Berger, Abhishek Meena, Tom Rhys Bishop, Daniel W. A. Noble, Pedro Simões, Julian Baur, Merel C. Breedveld, Erik I. Svensson, Lesley T. Lancaster, Jacintha Ellers, Alessio N. De Nardo, Marta A. Santos, Steven A. Ramm, Szymon M. Drobniak, Matteo Redana, Cristina Tuni, Natalie Pilakouta, Z. Valentina Zizzari, Graziella Iossa, Stefan Lüpold, Mareike Koppik, Regan Early, Clelia Gasparini, Shinichi Nakagawa, Malgorzata Lagisz, Amanda Bretman, Claudia Fricke, Rhonda R. Snook, Tom A. R. Price   +43 more
doaj   +1 more source

RECONSTRUCTIVE AND STABILIZING ABILITY OF THE MAIZE LINES IN STERILE CYTOPLASM “M” AND “C” TYPES OF CMS

Зерновое хозяйство России, 2019
Seeds of maize hybrids in the Russian Federation are obtained using CMS, therefore it is necessary to transfer the developed hybrids to a sterile basis to introduce them into production. The purpose of the work is to study the reaction of self-pollinated
G. Ya. Krivosheev, A. S. Ignatiev
doaj   +1 more source