Results 41 to 50 of about 188,278 (265)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Male Sterility in Cotton [PDF]

open access: yes, 2002
Not AvailableMale sterility refers to a condition in which nonfunctional pollen grains are produced in flowering plants. In flowering plants, the first case of male sterility was reported by Koelreuter in 1763.
Suman Bala Singh, Phundan Singh, C D Mayee
core  

Performance Survey and Comparison Between Rapid Sterility Testing Method and Pharmacopoeia Sterility Test

open access: yes, 2018
© 2017, The Author(s). The sterility test described in pharmacopoeial compendia requires a 14-day incubation period to obtain a valid analytical result.
Dua, K   +8 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Evaluation of the Sterility of PRP Obtained with Multi-bag System (PRPBAG®) [PDF]

open access: yes, 2023
Introduction:The aim of this study is demonstrating the sterility of PRPBAG®, a multi-bag completely closed PRP preparation system different than PRP kits in the market and determining preservability of the sterility of PRP produced with PRPBAG® up to 5 ...
Nang Hseng Kyio   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Sterility

open access: yes, 2012
Sterilit
Mohamed A. F. Noor (122377)   +3 more
core   +1 more source

Sub-Lethal Effect of Four Plant Extracts on Growth And Reproductive Parameters of Culex pipines molestus Forskal (Diptera: Culicidae) [PDF]

open access: yesمجلة التربية والعلم, 2019
The ethanol extracts of leaves Alianthus altissima, Carrisa grandiflora, fruits of Citrullus colocynthis and aerial parts of Ruta graveolens was tested against fourth instar larvae of the mosquito, Culex pipines molestua Forskal through sublethal doses ...
Atallah Mekhlif, Mohammad AbdulRazzak
doaj   +1 more source

Correlation between the response of maize lines to CMS and their origin

open access: yesЗерновое хозяйство России, 2023
Transferring maize hybrids to a sterile basis is the most important condition for their introduction into production. In this regard, it is important to study the behavior of the initial forms of hybrids, namely self-pollinated lines, in the sterile ...
G. Ya. Krivosheev, A. S. Ignatiev
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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