Results 41 to 50 of about 202,929 (259)

Polycystic ovary syndrome phenotypes in Iranian infertile women: a cross-sectional study

Middle East Fertility Society Journal
Objective Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrine disorder with diverse phenotypic presentations. This study aimed to evaluate the prevalence of PCOS phenotypes among Iranian infertile women and compare their clinical, hormonal, and ...
Nikoo Rezaei Borujerdi, Sahar Ardalan Khales, Habibollah Esmaily, Malihe Mahmoudinia   +3 more
doaj   +1 more source

Influence of the Addition of Height-Adjustable Worktables on Airborne Particle Concentration in a Cleanroom According to ISO 14644-1

Applied Sciences
Cleanrooms are essential environments for the production of sterile pharmaceuticals and medical devices, where airflow stability and contamination control are critical.
Pouya Jaberi, Simon Dietz, Torsten Wagner, Stephan Grass, Tobias Böhnke   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sub-Lethal Effect of Four Plant Extracts on Growth And Reproductive Parameters of Culex pipines molestus Forskal (Diptera: Culicidae) [PDF]

مجلة التربية والعلم, 2019
The ethanol extracts of leaves Alianthus altissima, Carrisa grandiflora, fruits of Citrullus colocynthis and aerial parts of Ruta graveolens was tested against fourth instar larvae of the mosquito, Culex pipines molestua Forskal through sublethal doses ...
Atallah Mekhlif, Mohammad AbdulRazzak
doaj   +1 more source

Machine learning-based detection of adventitious microbes in T-cell therapy cultures using long-read sequencing

Microbiology Spectrum, 2023
Assuring that cell therapy products are safe before releasing them for use in patients is critical. Currently, compendial sterility testing for bacteria and fungi can take 7–14 days.
James P. B. Strutt, Meenubharathi Natarajan, Elizabeth Lee, Denise Bei Lin Teo, Wei-Xiang Sin, Ka-Wai Cheung, Marvin Chew, Khaing Thazin, Paul W. Barone, Jacqueline M. Wolfrum, Rohan B. H. Williams, Scott A. Rice, Stacy L. Springs   +12 more
doaj   +1 more source

Performance Survey and Comparison Between Rapid Sterility Testing Method and Pharmacopoeia Sterility Test

, 2018
© 2017, The Author(s). The sterility test described in pharmacopoeial compendia requires a 14-day incubation period to obtain a valid analytical result.
Dua, K, Awasthi, R, Ghisleni, DDM, Bugno, A, Almodovar, AAB, de Jesus Andreoli Pinto, T, Hirota, MT, Saes, DPS, de Oliveira, WA   +8 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sterility

, 2012
Sterilit
Mohamed A. F. Noor (122377), Noor, Mohamed A. F., Shannon R. McDermott (25946), McDermott, Shannon R.   +3 more
core   +1 more source

ps2, the gene responsible for functional sterility in tomato, due to non-dehiscent anthers, is the result of a mutation in a novel polygalacturonase gene [PDF]

, 2009
The recessive mutation ps-2, which appeared spontaneously in tomato, confers functional male sterility due to non-dehiscent anthers. In this study, we isolated and characterized the PS-2 gene.
Gorguet, B.J.M., Schipper, E.H., Visser, R.G.F., Heusden, A.W., van, Lammeren, A.A.M., van   +4 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source