Results 51 to 60 of about 202,929 (259)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Correlation between the response of maize lines to CMS and their origin
Зерновое хозяйство России, 2023 Transferring maize hybrids to a sterile basis is the most important condition for their introduction into production. In this regard, it is important to study the behavior of the initial forms of hybrids, namely self-pollinated lines, in the sterile ...
G. Ya. Krivosheev, A. S. Ignatiev
doaj +1 more source
Worker sterility - Code and data
, 2018 Worker sterility - Code and ...
Andy Gardner (92711) +3 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Journal of Blood Medicine, 2020 Pierpaolo Di Micco,1 Vincenzo Russo,2 Daniela Mastroiacovo,3 Marijan Bosevski,4 Corrado Lodigiani5 1Department of Internal Medicine, Fatebenefratelli Hospital of Naples, Naples, Italy; 2Chair of Cardiology, Department of Translational Medical Sciences ...
Di Micco P +4 more
doaj
Plant Varieties Studying and Protection, 2016 Purpose. To develop a conceptually new method for determination of varietal purity (typicality), hybridity, sterility of seed lots. Methods of molecular biology (genomic DNA extraction, PCR with SSR markers application, capillary electrophoresis ...
Ж. В. Вдовиченко +3 more
doaj +1 more source
Sex-Linked Hybrid Sterility in a Butterfly [PDF]
, 2001 Recent studies, primarily in Drosophila, have greatly advanced our understanding of Haldane's rule, the tendency for hybrid sterility or inviability to affect primarily the heterogametic sex (Haldane 1922). Although dominance theory (Turelli and Orr 1995)
Yang, Ziheng H. +5 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Sterility and cytotoxicity tests results.
, 2016 Sterility and cytotoxicity tests results.
Pablo A. S. Vasquez (3597839) +6 more
core +1 more source