Results 41 to 50 of about 2,902 (114)

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae   +53 more
wiley   +1 more source

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li   +6 more
wiley   +1 more source

Presentation and Management of Addison's Disease in a 10‐Year‐Old Boy: A Case Report

open access: yesiLABMED, Volume 4, Issue 1, Page 59-63, March 2026.
ABSTRACT Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder characterized by impaired adrenal hormone production. We report a case of a 10‐year‐old boy with congenital adrenal hyperplasia and secondary Addison's disease on long‐term corticosteroid therapy who presented with recurrent non‐bilious vomiting, low‐grade fever,
Srinivasan Sivannan   +4 more
wiley   +1 more source

Pegvaliase Treatment for Adolescents With Phenylketonuria: A Multi‐Site Study

open access: yesJIMD Reports, Volume 67, Issue 2, March 2026.
ABSTRACT Phenylketonuria (PKU) is an inherited metabolic disorder causing elevated phenylalanine (Phe) levels and neurocognitive impairment if left untreated. While dietary therapy remains the treatment standard, adherence declines during adolescence. Pegvaliase, an injectable enzyme therapy approved for adults > 18 years in the United States, lowers ...
Suzanne Hollander   +7 more
wiley   +1 more source

Salicylic acid: a key natural foundation for next‐generation plant defense stimulators

open access: yesPest Management Science, Volume 82, Issue 3, Page 2165-2176, March 2026.
Salicylic acid is emerging as a key natural molecule in sustainable crop protection, supporting diverse strategies to stimulate and sustain plant immunity for a greener agricultural future. Abstract The field of crop protection is undergoing a major transition.
Ruth Oussou   +3 more
wiley   +1 more source

Immunostaining of P450c17, Aromatase and Oestrogen Receptor Alpha in Germ and Somatic Cells During Gonadal Development in Greater Rhea

open access: yesAnatomia, Histologia, Embryologia, Volume 55, Issue 2, March 2026.
ABSTRACT The greater rhea (Rhea americana), the largest bird species in South America, has significant economic value due to its meat, eggs, leather, feathers and oil. However, its lack of external sexual dimorphism poses challenges for reproductive management and breeding programmes.
Marilú Cristofoli   +7 more
wiley   +1 more source

Genetics of infertility and “assisted fertilization” in the Bible: The case of Abraham and his family

open access: yesAndrology, Volume 14, Issue 3, Page 641-650, March 2026.
Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni   +2 more
wiley   +1 more source

Efficacy and Tolerability of Metyrapone in Mild Autonomous Cortisol Secretion: Real‐World Findings From Clinical Practice

open access: yesClinical Endocrinology, Volume 104, Issue 3, Page 215-221, March 2026.
ABSTRACT Objective Mild autonomous cortisol secretion (MACS) is associated with increased cardiometabolic risk factors including hypertension, type 2 diabetes and dyslipidaemia. By using evening doses of metyrapone, a short‐acting 11‐β hydroxylase inhibitor, it has been shown that it is possible to reset the abnormal circadian cortisol rhythm in MACS ...
Simon Berry   +3 more
wiley   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

open access: yesImmunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan   +6 more
wiley   +1 more source

Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms. [PDF]

open access: yesAppl Microbiol Biotechnol, 2018
Szaleniec M   +4 more
europepmc   +1 more source

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