Results 21 to 30 of about 6,183 (145)

HYPOCHOLESTEROLEMIC EFFECT OF SAPONIN EXTRACTS IN EXPERIMENTAL ANIMALS [PDF]

Arab Universities Journal of Agricultural Sciences, 2018
Hypercholesterolemia was induced by feeding of rats on a high cholesterol diet (HCD) that contains cholesterol (1%), bile salts (0.25%) and coconut butter (15%) to evaluate the protective effect of steroidal saponins extracted from fenugreek and ...
Amany Ali, M. Tawfik, M. Hikal, M. Tag El-Din   +3 more
doaj   +1 more source

Triterpenoid and Steroidal Saponins Differentially Influence Soil Bacterial Genera

Plants, 2021
Plant specialized metabolites (PSMs) are secreted into the rhizosphere, i.e., the soil zone surrounding the roots of plants. They are often involved in root-associated microbiome assembly, but the association between PSMs and microbiota is not well ...
Masaru Nakayasu, Shinichi Yamazaki, Yuichi Aoki, Kazufumi Yazaki, Akifumi Sugiyama   +4 more
doaj   +1 more source

Qualitative and quantitative HPLC-ELSD-ESI-MS analysis of steroidal saponins in fenugreek seed

Acta Pharmaceutica, 2020
Fenugreek seeds are known as a source of various compounds, the most common of which are steroidal saponins. However, despite the growing interest in this plant material as a healing agent, spice and dietary supplement ingredient, the composition of ...
Król-Kogus Barbara, Głód Daniel, Krauze-Baranowska Mirosława   +2 more
doaj   +1 more source

Integrated Transcriptome–Metabolome Analysis of Differential Steroidal Saponin Accumulation and Candidate Biosynthetic Genes in Polygonatum cyrtonema

Horticulturae
Polygonatum cyrtonema is a traditional medicinal and edible plant, and steroidal saponins are among its major bioactive constituents. However, the molecular basis of their tissue-specific accumulation remains unclear.
Beining Liu, Lijie Wen, Qianyi Hu, Danqing Li, Boguo Zhao, Yiping Xia, Xiuyun Wang   +6 more
doaj   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Steroidal Glycosides from Allium tuberosum Seeds and Their Roles in Promoting Testosterone Production of Rat Leydig Cells

Molecules, 2020
A systematic phytochemical study on the components in the seeds of Allium tuberosum was performed, leading to the isolation of 27 steroidal glycosides (SGs 1–27).
Da-Bing Zhang, Xian-Yong Wei
doaj   +1 more source

Saponins in Cancer Treatment: Current Progress and Future Prospects

Pathophysiology, 2021
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming nature. Different saponins have been characterized and purified and are gaining attention in cancer chemotherapy. Saponins possess high structural diversity, which
Olusola Olalekan Elekofehinti, Opeyemi Iwaloye, Femi Olawale, Esther Opeyemi Ariyo   +3 more
doaj   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

Steroidal Saponins from the Mesocarp of the Fruits of (Arecaceae) and their Cytotoxic Activity

Natural Product Communications, 2015
Eight steroidal saponins ( 1–8 ), including one previously unreported derivative ( 1 ), have been isolated from the mesocarp of Raphia farinifera fruits by combined column chromatography and RP-HPLC methods.
Léon A. Tapondjou, Kristina J. Siems, Stefan Böttger, Matthias F. Melzig   +3 more
doaj   +1 more source