Results 1 to 10 of about 501 (137)

The origin and evolution of the diosgenin biosynthetic pathway in yam

Plant Communications, 2021
Diosgenin, mainly produced by Dioscorea species, is a traditional precursor of most hormonal drugs in the pharmaceutical industry. The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants remain unclear.
Jing Cai, Zhubo Dai, Huifeng Jiang
exaly   +3 more sources

Diosgenin: Chemistry, extraction, quantification and health benefits

Food Chemistry Advances, 2023
The occurrence of natural bioactive compounds is increasingly involved with pharmaceutical industries' exploring more source matrices. Diosgenin is a lot of delved bioactive compound naturally occurring in Trigonella foenum graecum, Dioscorea alata ...
Pradyuman Kumar, Prajya Arya
exaly   +3 more sources

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Frontiers in Pharmacology, 2022
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese medicine.
Yuan Zhou, Ruoqi Li, Yingyi Zheng, Meiying Song, Shanshan Zhang, Yunxia Sun, Mengying Wei, Xiang Fan, Xiang Fan   +8 more
doaj   +1 more source

Systems and in vitro pharmacology profiling of diosgenin against breast cancer

Frontiers in Pharmacology, 2023
Aim: The purpose of this study was to establish a mode of action for diosgenin against breast cancer employing a range of system biology tools and to corroborate its results with experimental facts.Methodology: The diosgenin-regulated domains implicated ...
Pukar Khanal, Vishal S. Patil, Vishwambhar V. Bhandare, Priyanka P. Patil, B. M. Patil, Prarambh S. R. Dwivedi, Kunal Bhattacharya, Kunal Bhattacharya, Darasaguppe R. Harish, Subarna Roy   +9 more
doaj   +1 more source

Fabrication and Assessment of Diosgenin Encapsulated Stearic Acid Solid Lipid Nanoparticles for Its Anticancer and Antidepressant Effects Using in vitro and in vivo Models

Frontiers in Neuroscience, 2022
Inflammatory cascade plays a pivotal role in the onset and progression of major depressive disorder (MDD) and glioblastoma multiforme (GBM). Therefore, questing natural compounds with anti-inflammatory activity such as diosgenin can act as a double-edged
Hina Khan, Sadia Nazir, Rai Khalid Farooq, Ishaq N. Khan, Aneela Javed, Aneela Javed   +5 more
doaj   +1 more source

Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. [PDF]

PLoS ONE, 2011
BACKGROUND: Diosgenin, a steroidal saponin obtained from fenugreek (Trigonella foenum graecum), was found to exert anti-carcinogenic properties, such as inhibiting proliferation and inducing apoptosis in a variety of tumor cells.
Pin-Shern Chen, Yuan-Wei Shih, Hsiang-Ching Huang, Hsing-Wen Cheng   +3 more
doaj   +1 more source

Altering Sterol Composition Implied That Cholesterol Is Not Physiologically Associated With Diosgenin Biosynthesis in Trigonella foenum-graecum

Frontiers in Plant Science, 2021
Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Liyang Cao, Zilin Zhou, Zilin Zhou, Jia Sun, Changfu Li, Changfu Li, Yansheng Zhang, Yansheng Zhang   +7 more
doaj   +1 more source

Anti-Allergic Diarrhea Effect of Diosgenin Occurs via Improving Gut Dysbiosis in a Murine Model of Food Allergy

Molecules, 2021
Although the anti-allergic and prebiotic activities of diosgenin have been reported, the influence of diosgenin on intestinal immune and epithelial cells remains unclear.
Chung-Hsiung Huang, Chorng-Liang Pan, Guo-Jane Tsai, Chun-Ju Chang, Wei-Chung Tsai, Shueh-Yu Lu   +5 more
doaj   +1 more source

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent

Journal of Lipid Research, 2009
Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion and ...
Ryan E. Temel, J. Mark Brown, Yinyan Ma, Weiqing Tang, Lawrence L. Rudel, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +7 more
doaj   +1 more source

Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1

Cellular Physiology and Biochemistry, 2017
Background/Aims: We investigated how diosgenin, a steroidal sapogenin, has anti-tumor necrosis factor-α (TNF-α) effects in human aortic endothelial cells (HAECs).
Won Seok Yang, Soo Young Moon, Mee Jeong Lee, Eun Kyoung Lee, Su-Kil Park   +4 more
doaj   +1 more source