Results 1 to 10 of about 995 (113)

Altering Sterol Composition Implied That Cholesterol Is Not Physiologically Associated With Diosgenin Biosynthesis in Trigonella foenum-graecum [PDF]

Frontiers in Plant Science, 2021
Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Liyang Cao, Zilin Zhou, Zilin Zhou, Jia Sun, Changfu Li, Changfu Li, Yansheng Zhang, Yansheng Zhang   +7 more
doaj   +5 more sources

Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. [PDF]

PeerJ
Dioscorea cirrhosa L. (D. cirrhosa) tuber is a traditional medicinal plant that is abundant in various pharmacological substances. Although diosgenin is commonly found in many Dioscoreaceae plants, its presence in D. cirrhosa remained uncertain.
Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo   +6 more
doaj   +5 more sources

Comparative Transcriptome Analysis Identifies Genes Involved in Diosgenin Biosynthesis in Trigonella foenum-graecum L. [PDF]

Molecules, 2019
Trigonella foenum-graecum L. (fenugreek) is a valuable resource of producing diosgenin which serves as a substrate for synthesizing more than two hundred kinds of steroidal drugs.
Chen Zhou, Xiaohua Li, Zilin Zhou, Changfu Li, Yansheng Zhang   +4 more
doaj   +5 more sources

TfWRKY40 positively regulates diosgenin biosynthesis in Trigonella foenum-graecum L. [PDF]

Frontiers in Plant Science
Diosgenin is a bioactive steroidal natural product extraced from plants and serves as an important precursor for the industrial production of steroidal hormone drugs.
Chuanjia Xu, Chuanjia Xu, Nan Tang, Yehan Xu, Changfu Li, Yansheng Zhang, Yansheng Zhang   +6 more
doaj   +3 more sources

The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis. [PDF]

Int J Mol Sci, 2023
Dioscorea zingiberensis is a perennial herb famous for the production of diosgenin, which is a valuable initial material for the industrial synthesis of steroid drugs. Sterol C26-hydroxylases, such as TfCYP72A616 and PpCYP72A613, play an important role in the diosgenin biosynthesis pathway.
Wang W, Hou L, Li S, Li J.
europepmc   +3 more sources

An HD-ZIP I Transcription Factor DZHDZ32 Upregulates Diosgenin Biosynthesis in <i>Dioscorea zingiberensis</i>. [PDF]

Int J Mol Sci
Diosgenin, a crucial precursor for steroidal drug production, has poorly understood regulatory pathways. Diosgenin is the primary active component of Dioscorea zingiberensis. Notably, D. zingiberensis also possesses the highest diosgenin content among Dioscorea species, reaching up to 16.15% of dry weight.
Yang H, Li Y, Hu Z, Li J.
europepmc   +3 more sources

Diosgenin producing Bacillus sp. strain IRMC27M2 as a genome-mined weapon against multidrug-resistant Candidozyma (Candida) auris [PDF]

Computational and Structural Biotechnology Journal
Candidozyma auris (Candida auris) is an emerging multidrug-resistant (MDR) fungal pathogen prioritised by the World Health Organisation that poses a significant global health threat due to high mortality. Discovering novel antifungal drugs is crucial for
Rahaf Alquwaie, Noor B. Almandil, Reem AlJindan, Nehal Mahmoud, Sarah Almofty, Dana Almohazey, Hoor Hashim Alqudihi, Sarah Hunachagi, Tharmathass Stalin Dhas, P. Sowmiya, Sayed AbdulAzeez, J. Francis Borgio   +11 more
doaj   +2 more sources

Melatonin confers fenugreek tolerance to salinity stress by stimulating the biosynthesis processes of enzymatic, non-enzymatic antioxidants, and diosgenin content

Frontiers in Plant Science, 2022
Salinity-induced stress is widely considered a main plant-growth-limiting factor. The positive effects of melatonin in modulating abiotic stresses have led this hormone to be referred to as a growth regulator in plants.
Maryam Mohamadi Esboei, Amin Ebrahimi, Mohamad Reza Amerian, Hadi Alipour   +3 more
doaj   +3 more sources

Exogenous 24-epibrassinolide ameliorates tolerance to high-temperature by adjusting the biosynthesis of pigments, enzymatic, non-enzymatic antioxidants, and diosgenin content in fenugreek

Scientific Reports, 2023
High-temperature stress is widely considered a main plant-growth-limiting factor. The positive effects of 24-epibrassinolide (EBR) as analogs of brassinosteroids (BRs) in modulating abiotic stresses have led this hormone to be referred to as a growth ...
Shahla Sheikhi, Amin Ebrahimi, Parviz Heidari, Mohamad Reza Amerian, Sajad Rashidi-Monfared, Hadi Alipour   +5 more
doaj   +3 more sources

Next-generation sequencing of representational difference analysis products for identification of genes involved in diosgenin biosynthesis in fenugreek (Trigonella foenum-graecum). [PDF]

Planta, 2017
Representational difference analysis of cDNA was performed and differential products were sequenced and annotated. Candidate genes involved in biosynthesis of diosgenin in fenugreek were identified. Detailed mechanism of diosgenin synthesis was proposed. Fenugreek (Trigonella foenum-graecum L.) is a valuable medicinal and crop plant.
Ciura J, Szeliga M, Grzesik M, Tyrka M.
europepmc   +5 more sources