Results 1 to 10 of about 1,104 (142)

Comparative Transcriptome Analysis Identifies Genes Involved in Diosgenin Biosynthesis in Trigonella foenum-graecum L. [PDF]

Molecules, 2019
Trigonella foenum-graecum L. (fenugreek) is a valuable resource of producing diosgenin which serves as a substrate for synthesizing more than two hundred kinds of steroidal drugs.
Changfu Li, Yansheng Zhang
exaly   +8 more sources

Altering Sterol Composition Implied That Cholesterol Is Not Physiologically Associated With Diosgenin Biosynthesis in Trigonella foenum-graecum [PDF]

Frontiers in Plant Science, 2021
Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Changfu Li, Yansheng Zhang
exaly   +7 more sources

TfWRKY40 positively regulates diosgenin biosynthesis in Trigonella foenum-graecum L. [PDF]

Frontiers in Plant Science
Diosgenin is a bioactive steroidal natural product extraced from plants and serves as an important precursor for the industrial production of steroidal hormone drugs.
Chuanjia Xu, Chuanjia Xu, Nan Tang, Yehan Xu, Changfu Li, Yansheng Zhang, Yansheng Zhang   +6 more
doaj   +6 more sources

Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. [PDF]

PeerJ
Dioscorea cirrhosa L. (D. cirrhosa) tuber is a traditional medicinal plant that is abundant in various pharmacological substances. Although diosgenin is commonly found in many Dioscoreaceae plants, its presence in D. cirrhosa remained uncertain.
Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo   +6 more
doaj   +5 more sources

Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study [PDF]

BMC Plant Biology
Background Diosgenin is an important steroidal precursor renowned for its diverse medicinal uses. It is predominantly sourced from Dioscorea species, particularly Dioscorea zingiberensis.
Shi xian Sun, Yanmei Li, Lu Jia, Shili Ye, Yunpeng Luan   +4 more
doaj   +3 more sources

Systemic role of melatonin in enhancing temperature stress tolerance in fenugreek: coordination of antioxidant defense, hormonal regulation, energy status, sulfur metabolism, and diosgenin pathway genes [PDF]

BMC Plant Biology
Background Temperature stresses, encompassing heat and cold, significantly hinder the growth and productivity of fenugreek. Melatonin, known for its antioxidant and signaling properties, enhances plant stress tolerance, yet its specific role and mode of ...
Shahrokh Gharanjik, Amin Ebrahimi, Liela Rezaei Somee, Zeinab Chaghakaboodi, Hadi Alipour   +4 more
doaj   +3 more sources

Silymarin and serotonin, individually and synergistically, enhance fenugreek resistance to salt stress by modulating pathways involved in chlorophyll biosynthesis, defense system, hormonal regulation, ion redox balance, and diosgenin production [PDF]

BMC Plant Biology
Background Salinity stress, as one of the most significant and widespread abiotic stresses, affects a large portion of the world’s arable lands. Developing salt-tolerant plants through classical breeding, biotechnology, and molecular methods is time ...
Sajedeh Roshandel, Amin Ebrahimi, Shahrokh Gharanjik   +2 more
doaj   +3 more sources

Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum. [PDF]

Plant Biotechnol J
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Lim J, Kim K, Heo J, Seo SM, Choung S, Kim H, Choi Y, Park K, Yun H, Kim D, Lee ES, Lee J, Warsadiharja SM, Lee SB, Han S, Park SJ, Kim SG.   +16 more
europepmc   +2 more sources

Diosgenin producing Bacillus sp. strain IRMC27M2 as a genome-mined weapon against multidrug-resistant Candidozyma (Candida) auris [PDF]

Computational and Structural Biotechnology Journal
Candidozyma auris (Candida auris) is an emerging multidrug-resistant (MDR) fungal pathogen prioritised by the World Health Organisation that poses a significant global health threat due to high mortality. Discovering novel antifungal drugs is crucial for
Rahaf Alquwaie, Noor B. Almandil, Reem AlJindan, Nehal Mahmoud, Sarah Almofty, Dana Almohazey, Hoor Hashim Alqudihi, Sarah Hunachagi, Tharmathass Stalin Dhas, P. Sowmiya, Sayed AbdulAzeez, J. Francis Borgio   +11 more
doaj   +2 more sources

Advances in fenugreek breeding: novel genetic and omic approaches [PDF]

Frontiers in Plant Science
Fenugreek (Trigonella foenum-graecum L.) has long been valued for its diverse applications in culinary, medicinal, and cultural traditions across the globe.
Solanki Bal, Amit Baran Sharangi, Mohd Saeed, Ali Alkhathami, Samra Siddiqui, Nadiyah M. Alabdallah   +5 more
doaj   +2 more sources