Results 41 to 50 of about 1,074 (118)

The Biochemical Role of Bitter Melon (Momordica charantia L.) Aqueous Extract in Regulating Hepatic Gluconeogenesis in Rats Fed Ketogenic Diet

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Metabolic effects of a ketogenic diet and bitter melon extract on hepatic gluconeogenesis and glucose–lipid homeostasis. ABSTRACT The ketogenic diet (KD) has been suggested as a useful lifestyle intervention for metabolic syndrome; however, its long‐term metabolic effects remain debated.
Ghalia Shamlan
wiley   +1 more source

Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Laboratory Animal Research, 2016
To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured in trimethyltin (TMT)-injected transgenic ...
Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae, Dae-Youn Hwang   +9 more
doaj   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Comparative Profiling of Capsicum frutescens and C. annuum Reveals Superior Bioactivities and Nutritional Advantages for Functional Food Applications

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Systematic bioactivity profiling revealed C. frutescens demonstrated significantly superior radical scavenging capacity (DPPH IC50: 111.96 ± 3.24 μg/mL; 2.5‐fold enhancement, p < 0.001), enhanced broad‐spectrum antibacterial efficacy (zone diameters: 8–22 mm), and notable cytotoxic activity meeting NCI preliminary criteria (LC50: 29.24 ± 1.15 μg/mL ...
Shahin Akter, Muhammad Mamunur Rashid Mahib, Mohammad Razuanul Hoque, Md. Rafiqul Islam, Md. Golam Kabir   +4 more
wiley   +1 more source

Molecular characterization of diosgenin biosynthesis in different organs of Trigonella foenum-graecum L.

Journal of Aridland Agriculture
Fenugreek, an annual herb, is a significant source of diosgenin, a triterpene with bioactive properties. This study aimed to molecularly characterize diosgenin biosynthesis in various organs of fenugreek, including flowers, immature leaves, developing leaves, mature leaves, stems, roots, and pods. The biosynthetic pathway involves vital enzymes such as
Do Yeon Kwon, Jinsu Lim, Ramaraj Sathasivam, Md. Romij Uddin, Jae Kwang Kim, Sang Un Park   +5 more
openaire   +1 more source

Switchgrass Steroidal Saponins Reduce Fungal Disease but Decrease Yeast Fermentation Yield

GCB Bioenergy, Volume 18, Issue 1, January 2026.
Yeast fermentation of switchgrass biomass is inhibited for certain genotypes, especially those with high concentrations of steroidal saponins that protect against fungal disease. Inhibition can be reversed through (1) ergosterol addition, (2) fermentation with the bacterium Zymonomas mobilis, or (3) in different collection years.
Acer VanWallendael, Xingxing Li, Dan Xie, Kallysa Taylor, Evan Handowski, Jose Serate, Lillian M. Barten, Yaoping Zhang, Kurt Thelen, Robert L. Last, Trey K. Sato, David B. Lowry   +11 more
wiley   +1 more source

Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.)

Journal of Medicinal Plants, 2010
Fenugreek (Trigonella foenum-graecum L.) has a long and respected history of medicinal uses in Middle East and Persian medicine. The hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin ...
A Mehrafarin, A Qaderi, Sh Rezazadeh, H Naghdi Badi, Gh Noormohammadi, E Zand   +5 more
doaj  

NUTRITIONAL COMPOSITION OF DIOSCOREA HISPIDA FROM DIFFERENT LOCATIONS AROUND LEUSER ECOSYSTEM AREA

Jurnal Natural, 2018
Proximate analysis of Dioscorea hispida tubers, collected from five locations around Leuser ecosystem in Aceh Province, showed variations amongst samples.
Sitti Saleha, Nurdin Saidi, Saiful ., Murniana ., Saida Rasnovi, Teuku M. Iqbalsyah   +5 more
doaj   +1 more source