Results 61 to 70 of about 1,104 (142)

Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Laboratory Animal Research, 2016
To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured in trimethyltin (TMT)-injected transgenic ...
Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae, Dae-Youn Hwang   +9 more
doaj   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Comparative Profiling of Capsicum frutescens and C. annuum Reveals Superior Bioactivities and Nutritional Advantages for Functional Food Applications

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Systematic bioactivity profiling revealed C. frutescens demonstrated significantly superior radical scavenging capacity (DPPH IC50: 111.96 ± 3.24 μg/mL; 2.5‐fold enhancement, p < 0.001), enhanced broad‐spectrum antibacterial efficacy (zone diameters: 8–22 mm), and notable cytotoxic activity meeting NCI preliminary criteria (LC50: 29.24 ± 1.15 μg/mL ...
Shahin Akter, Muhammad Mamunur Rashid Mahib, Mohammad Razuanul Hoque, Md. Rafiqul Islam, Md. Golam Kabir   +4 more
wiley   +1 more source

Switchgrass Steroidal Saponins Reduce Fungal Disease but Decrease Yeast Fermentation Yield

GCB Bioenergy, Volume 18, Issue 1, January 2026.
Yeast fermentation of switchgrass biomass is inhibited for certain genotypes, especially those with high concentrations of steroidal saponins that protect against fungal disease. Inhibition can be reversed through (1) ergosterol addition, (2) fermentation with the bacterium Zymonomas mobilis, or (3) in different collection years.
Acer VanWallendael, Xingxing Li, Dan Xie, Kallysa Taylor, Evan Handowski, Jose Serate, Lillian M. Barten, Yaoping Zhang, Kurt Thelen, Robert L. Last, Trey K. Sato, David B. Lowry   +11 more
wiley   +1 more source

Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 328-345, January 2026.
Summary Transient expression in Nicotiana benthamiana offers a powerful and versatile platform for rapid production of complex specialized metabolites. Steroidal glycoalkaloids (SGAs) and steroidal saponins produced by members of the Solanaceae family are known for their diverse structures and activities including antimicrobial, anticancer, antiviral ...
Sachin A. Gharat, Adam Jozwiak, Ilana Rogachev, Elinor A. Sharon, Sagit Meir, Ashok P. Giri, Asaph Aharoni   +6 more
wiley   +1 more source

Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.)

Journal of Medicinal Plants, 2010
Fenugreek (Trigonella foenum-graecum L.) has a long and respected history of medicinal uses in Middle East and Persian medicine. The hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin ...
A Mehrafarin, A Qaderi, Sh Rezazadeh, H Naghdi Badi, Gh Noormohammadi, E Zand   +5 more
doaj  

Impact of an arbuscular mycorrhizal fungal inoculum and exogenous MeJA on fenugreek secondary metabolite production under water deficit

, 2020
Trigonella foenum-graecum (fenugreek) is a leguminous plant that produces secondary metabolites frequently used in medicinal and food preparation. Here, the role of an arbuscular mycorrhizal (AM) fungal inoculum, alone or in combination with methyl ...
Fotopoulos, Vasileios, Mashreghi, Mansour, Nerva, Luca, Ganjeali, Ali, Balestrini, Raffaella, Chitarra, Walter, Volpe, Veronica, Irankhah, Simin, Antoniou, Chrystalla, Cheniany, Monireh, Lumini, Erica   +10 more
core   +1 more source

Shengdihuang Xiyangshen Zhimu Cangzhu Formula Improves Hepatic Glycogen Synthesis via the JNK/c‐Jun/IRS1/GSK3β Signaling Pathway

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetes mellitus (DM) is one of the major chronic diseases endangering human health worldwide, and disorders of hepatic glucose metabolism are its main feature. Glucose homeostasis is maintained by hepatic glycogen synthesis and catabolism, glycolysis, and gluconeogenesis.
Kewen Qu, Mei Li, Jinxu Sun, Shangping Wu, Xinyu Liu, Kanglin Liu, Shuxin Wu, Xiangyu Guo, Huantian Cui   +8 more
wiley   +1 more source

Metabolomic changes in potato (Solanum tuberosum L.) under different drought stress levels

Guan'gai paishui xuebao
【Objective】Drought is one of the major abiotic stresses limiting potato growth and yield in many regions. Understanding metabolic responses of potato to drought is essential for elucidating the mechanisms underlying its adaptation to drought and breeding
LIU Yaqi, SU Riguga, LIU Sujun
doaj   +1 more source