Results 71 to 80 of about 239,005 (157)

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Diosgenin hemihydrate

, 2012
Diosgenin [or (22R,25R)-spirost-5-en-3β-ol] is the starting material of the Marker degradation, a cheap semi-synthesis of progesterone, which has been designated as an International Historic Chemical Landmark.
Gabriel Guerrero-Luna, María-Guadalupe Hernández Linares, Marcos Flores-Alamo, Anselmo A. Martínez-Gallegos, Sylvain Bernès   +4 more
core   +1 more source

Review on Fenugreek (Trigonella foenum-graecum L.) and its Important Secondary Metabolite Diosgenin [PDF]

, 2018
Fenugreek (Trigonella foenum-graecum L.) is a medicinal plant used worldwide since ancient times. Its use as smelling agent and spice was documented since 15th century.
Spandan CHAUDHARY, IRITI, Marcello, Surendra K. CHIKARA, Pooja Shah CHAUDHARY, Mahesh C. SHARMA, CHIKARA, Surendra K., CHAUDHARY, Pooja Shah, Marcello IRITI, CHAUDHARY, Spandan, SHARMA, Mahesh C.   +9 more
core   +2 more sources

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Diosgenin inhibits cell proliferation of primary human thyrocytes via downregulation of PI3K/Akt signaling pathway [PDF]

, 2018
Purpose: To determine the potential influence of diosgenin on proliferation of human thyrocytes and its possible mechanism.Methods: Primary human thyrocytes were cultured and treated with diosgenin at various time intervals.
Lu, Yuxian, Bian, Dezhi, Xu, Ke, Qian, Xiaojuan, Wen, Fen, Liu, Yanmei   +5 more
core   +1 more source

In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity

, 2015
Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity.
Jing-Hsien Chen, Chih-Tai Chen, Hui-Hsuan Lin, Zhi-Hong Wang, Cheng-Chin Hsu   +4 more
core   +1 more source

Megakaryocytic differentiation mechanisms in diosgenin-treated cells in relation to the SHh pathway.

, 2014
Diosgenin induced megakaryocytic differentiation in HEL cells. The SHh pathway is involved in diosgenin-induced megakaryocytic differentiation since its inhibition blocks this phenomenon.
David Yannick Leger (553347), Jean-Louis Beneytout (553346), Youness Limami (553345), Lamia Ghezali (553344), Bertrand Liagre (56535)   +4 more
core   +1 more source

Simultaneous Analysis of Diosgenin and Sarsasapogenin in Asparagus officinalis Byproduct by Thin-layer Chromatography

, 2011
Introduction - Asparagus officinalis L. has several biological activities including antifungal, antiviral and antitumoral activities due to the steroidal saponins. Normally diosgenin and sarsasapogenin are analysed separately by thin-layer chromatography
Zhao, B, Wang, Xiaodong, Wang, Liwei, Zhao, Bing, Yuan, Xiaofan   +4 more
core   +1 more source

Diosgenin does not express estrogenic activity: a uterotrophic assay

, 2014
This study assessed the effects of diosgenin on estrogenic activity using a uterotrophic assay. Immature female rats received diosgenin orally at doses of 200, 100, or 20 mg/kg body mass; and 17 alpha ethynylestradiol at doses of 1 or 0.3 mu g ...
Filipović, Branko, Milošević, Verica, Šošić-Jurjević, Branka, Nestorović, Nataša, Ristić, Nataša, Jarić, Ivana, Živanović, Jasmina   +6 more
core   +1 more source

Dopamine enhances salinity tolerance and elicits diosgenin biosynthesis in fenugreek (Trigonella foenum-graecum L.)

BMC Plant Biology
Abstract Background Salinity stress compromises crop quality and yield, threatening food security and seriously constraining sustainable agriculture. Dopamine (DA) has emerged as a promising elicitor for enhancing stress tolerance and the quantity and quality of secondary
Mohammad Amin Hosseinzadeh, Amin Ebrahimi, Shahrokh Gharanjik   +2 more
openaire   +1 more source