Results 51 to 60 of about 239,005 (157)

Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa

The FEBS Journal, Volume 293, Issue 17, Page 5318-5339, September 2026.
Multiple peptide resistance factor (MprF) is a bacterial enzyme that carries out the aminoacylation of lipid head groups. CryoEM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from its homologues in Rhizobium. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent
Shaileshanand Jha, Kutti R. Vinothkumar
wiley   +1 more source

Diosgenin: Chemistry, extraction, quantification and health benefits

, 2023
The occurrence of natural bioactive compounds is increasingly involved with pharmaceutical industries' exploring more source matrices. Diosgenin is a lot of delved bioactive compound naturally occurring in Trigonella foenum graecum, Dioscorea alata ...
Pradyuman Kumar, Prajya Arya, Mohona Munshi   +2 more
core   +1 more source

Optimizing the Anti‐Inflammatory Efficacy of Pakistani Spice Blends: A Farm‐to‐Fork Analysis of Phytochemical Synergy and Processing Stability

eFood, Volume 7, Issue 4, August 2026.
This review aims to evaluate the anti‐inflammatory potential of these spice blends, emphasizing their synergistic mechanisms, and to investigate how cultivation practices, post‐harvest processing, and environmental stressors shape their medicinal efficacy. By addressing this gap, it seeks to provide a comprehensive framework for integrating traditional
Qudrat Ullah, Waqas Haider, Farhang Hameed Awlqadr, Ahmed Bilal, Muhammad Tayyab Arshad, Emmanuel Laryea   +5 more
wiley   +1 more source

Diosgenin Modulates Vascular Smooth Muscle Cell Function by Regulating Cell Viability, Migration, and Calcium Homeostasis

, 2010
In this study, we compared the potencies of diosgenin, a plant-derived sapogenin structurally similar to estrogen and progesterone, on vascular smooth muscle functions ranging from contraction and migration to apoptosis.
Cornelis van Breemen, Syyong, Harley, Harley T. Syyong, Sahar Abdoli Yazdi, Navarro Dorado, Jorge, van Breemen, Cornelis, Kariminia, Amina, Boris Kuzeljevic, Jorge Navarro Dorado, Kuzeljevic, Boris, Julia T. N. Lam, Mitra Esfandiarei, Hu, Kaiji, Esfandiarei, Mitra, Abdoli Yazdi, Sahar, Kaiji Hu, Amina Kariminia, Lam, Julia   +17 more
core   +1 more source

Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Laboratory Animal Research, 2016
To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured in trimethyltin (TMT)-injected transgenic ...
Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae, Dae-Youn Hwang   +9 more
doaj   +1 more source

Phenolic composition and multi‐target bioactivities of Globularia alypum extracts across seasons

JSFA reports, Volume 6, Issue 8, Page 314-330, August 2026.
Abstract Background This study investigates the influence of seasonal variation on the phytochemical profile and biofunctional activities of ethanolic leaf extracts from Globularia alypum. Leaves collected across four seasons were extracted with a hydroethanolic solvent (80:20, v/v) and analyzed by LC‐ESI‐MS/MS.
Mohammed Messaoudi, Khalil Guelift, Mokhtar Benmohamed, Khaled Kherraz, Latifa Khattabi, Afaf Khadra Bendrihem, Khaled Aggoun, Barbara Sawicka, Lilya Harchaoui, Mohamed Amine Ferhat, Salah Neghmouche Nacer, Stefania Garzoli   +11 more
wiley   +1 more source

Diosgenin from Solanum Species

, 1969
Diosgenin from Solanum ...
Sipra Mookherjea, Rabecca Mathew
core   +1 more source

Ethylene treatment improves diosgenin accumulation in in vitro cultures of Dioscorea zingiberensis via up-regulation of CAS and HMGR gene expression [PDF]

, 2013
Background: The perennial medicinal herb Dioscorea zingiberensis is a very important plant used for steroid drug manufacturing for its high level of diosgenin in rhizome. Although the stimulation of diosgenin accumulation by ethylene has been reported in
He, Ji, Diarra,Sabake T, Wang, Jianbo, Li,Jiaru, Diarra, Sabake T., Wang,Jianbo, Li, Jiaru, He,Ji   +7 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 739-750, May 2026.
LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang, Zixu Huang, Xiaohui Kuang, Yali Nan, Zhiwen Zhang, Zongming Song   +5 more
wiley   +1 more source