Results 11 to 20 of about 2,018 (130)

TfWRKY40 positively regulates diosgenin biosynthesis in Trigonella foenum-graecum L. [PDF]

Frontiers in Plant Science
Diosgenin is a bioactive steroidal natural product extraced from plants and serves as an important precursor for the industrial production of steroidal hormone drugs.
Chuanjia Xu, Chuanjia Xu, Nan Tang, Yehan Xu, Changfu Li, Yansheng Zhang, Yansheng Zhang   +6 more
doaj   +2 more sources

Preparation Of Diosgenin-Encapsulated Microspheres By Spray Drying Technique

, 2023
Diosgenin, a naturally occurring steroid sapogenin possessing diverse therapeutic properties, represents a bioactive compound of interest. However, its complete pharmaceutical utilization has been impeded by inherent challenges, primarily associated with
Mangla, Mohit, Sanduja, Mohit, Tiwari, Ram Hari, Nayak, Amit Kumar   +3 more
core   +1 more source

Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1

Cellular Physiology and Biochemistry, 2017
Background/Aims: We investigated how diosgenin, a steroidal sapogenin, has anti-tumor necrosis factor-α (TNF-α) effects in human aortic endothelial cells (HAECs).
Won Seok Yang, Soo Young Moon, Mee Jeong Lee, Eun Kyoung Lee, Su-Kil Park   +4 more
doaj   +1 more source

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

BMC Complementary Medicine and Therapies, 2020
Background Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Diosgenin is a natural steroidal saponin with a variety of beneficial effects, including antidiabetic effects, and is a raw material for the ...
Jinhong Leng, Xiaohua Li, He Tian, Chang Liu, Yining Guo, Su Zhang, Yang Chu, Jian Li, Ying Wang, Ling Zhang   +9 more
doaj   +1 more source

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Open Life Sciences, 2021
Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties ...
Zhao Hengfang, Zhang Xiaoyan, Zhang Bojing, Qu Xiaoyuan   +3 more
doaj   +1 more source

Diosgenin protects retinal pigment epithelial cells from inflammatory damage and oxidative stress induced by high glucose by activating AMPK/Nrf2/HO‐1 pathway

Immunity, Inflammation and Disease, 2022
Introduction Diosgenin is a natural steroidal compound with reported antidiabetic and many other protective properties. This study aimed to explore the protective effect of diosgenin on high‐glucose (HG)‐induced retinal pigment epithelial cells.
Yang Hao, Xuefeng Gao
doaj   +1 more source

Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach

Journal of Analytical Methods in Chemistry, 2022
Diosgenin, a steroidal sapogenin, has attracted attention worldwide owing to its pharmacological properties, including antitumor, cardiovascular protective, hypolipidemic, and anti-inflammatory effects.
Pei Liu, Lin Xu, Jing-han Guo, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Guang-xin Miao, Cui-zhe Liu, Jian-yu Zhou   +10 more
doaj   +1 more source

Effect of diosgenin on lipid metabolism in rats.

Journal of Lipid Research, 1979
The purpose of this study was to determine whether diosgenin suppresses cholesterol absorption in rats, and to examine relevant changes in cholesterol and bile acid metabolism.
M N Cayen, D Dvornik
doaj   +1 more source

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats

Journal of Diabetes Research, 2017
Objective. To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. Methods.
Lixia Ji, Lixia Cheng, Zhihong Yang
doaj   +1 more source

Optimization of diosgenin extraction from Dioscorea deltoidea tubers using response surface methodology and artificial neural network modelling.

PLoS ONE, 2021
IntroductionDioscorea deltoidea var. deltoidea (Dioscoreaceae) is a valuable endangered plant of great medicinal and economic importance due to the presence of the bioactive compound diosgenin. In the present study, response surface methodology (RSM) and
Romaan Nazir, Devendra Kumar Pandey, Babita Pandey, Vijay Kumar, Padmanabh Dwivedi, Aditya Khampariya, Abhijit Dey, Tabarak Malik   +7 more
doaj   +1 more source