Results 21 to 30 of about 501 (137)

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats

Journal of Diabetes Research, 2017
Objective. To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. Methods.
Lixia Ji, Lixia Cheng, Zhihong Yang
doaj   +1 more source

Optimization of diosgenin extraction from Dioscorea deltoidea tubers using response surface methodology and artificial neural network modelling.

PLoS ONE, 2021
IntroductionDioscorea deltoidea var. deltoidea (Dioscoreaceae) is a valuable endangered plant of great medicinal and economic importance due to the presence of the bioactive compound diosgenin. In the present study, response surface methodology (RSM) and
Romaan Nazir, Devendra Kumar Pandey, Babita Pandey, Vijay Kumar, Padmanabh Dwivedi, Aditya Khampariya, Abhijit Dey, Tabarak Malik   +7 more
doaj   +1 more source

Stability study of nanoemulsions of diosgenin

Disciplinarum Scientia - Ciências Naturais e Tecnológicas, 2021
Nanotechnology is an interdisciplinary scientific field where it is possible to manipulate, alter and develop new materials at the nanoscale, changing their properties. In the pharmaceutical and cosmetic areas there is the production of nanocarriers for pharmaceuticals, which can protect, encapsulate and release pharmacologically active compounds.
Priscila Eismann, Ana Júlia Figueiró Dalcin, Ronaldo Gonçalves Leiria, Sérgio Roberto Mortari, Patrícia Gomes   +4 more
openaire   +2 more sources

Screening and Selection of a New Medium and Culture Conditions for Diosgenin Production via Microbial Biocatalysis of SYt1

Bioengineering
Diosgenin (DSG) is a phytosterol saponin mainly found in Dioscorea zingiberensis C.H. Wright. It has shown promising results in treating various diseases such as cancer, diabetes, arthritis, asthma, and cardiovascular diseases.
Shiyao Han, Yiyu Zhao, Fangyuan Mou, Zhen Yang, Ningxiao Li, Mengqi Cheng, Heshaungyi Xie, Baofu Qin, Young Tang   +8 more
doaj   +1 more source

In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors

International Journal of Secondary Metabolite, 2020
Glutathione reductase inhibitors are very popular antimalarial and anticancer agents. In this study, in vitro inhibition effects of β-sitosterol, stigmasterol, diosgenin and jervine which containing steroidal structure were determined against glutathione
Tuba Aydin
doaj   +1 more source

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

A Method for Improving Microbial Conversion of Diosgenin and Separation and Identification of the Product

Fermentation, 2023
Diosgenin, a hydrolysis product from Dioscorea plants, can be used as a precursor of steroid drugs (e.g., progesterone, testosterone, and glucocorticoid).
Fangyuan Mou, Junmian Tian, Yulu Li, Shiyao Han, Ruifen Shang, Yuxin Song, Shirong Feng, Yongli Zhang, Rang Cao, Baofu Qin   +9 more
doaj   +1 more source

Impact of Sprouting and Brachystegia eurycoma Supplementation on the Functional, Proximate Composition, and Bioactive, Antioxidant, and Enzyme‐Inhibitory Properties of Sorghum Flour

Food Chemistry International, EarlyView.
Sprouting and Brachystegia eurycoma supplementation improved sorghum flour nutrition, antioxidant activity and enzyme inhibition for functional foods. ABSTRACT Sprouting and cereal–legume supplementation are effective strategies for improving the functional, nutritional, and nutraceutical qualities of cereal‐based flour and products.
Khadijat Oluwashola Abdulrazaaq, Emmanuel Anyachukwu Irondi, Emmanuel Oladipo Ajani   +2 more
wiley   +1 more source

Protective Effect of Diosgenin against H2O2-Induced Oxidative Stress on H9C2 Cells [PDF]

Journal of Cell and Molecular Research, 2016
Diosgenin is an important compound in pharmaceutical industry. It has various effects such as hypocholesterolemic action or antioxidant activity in HIV infected patients. Biological oxidation pathways are involved in causing or aggravating heart disease.
Samaneh Jamshidi, Mehrdad Lahouti, Mohammad Taher Boroushaki, Ali Ganjeali, Ahmad Ghorbani, Mehdi Bihamta toosi   +5 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source