Results 31 to 40 of about 9,241 (226)
Hydroxylation of Diosgenin by Absidia coerulea [PDF]
Natural Product Communications, 2010 Microbial transformation of diosgenin (1) using Absidia coerulea yielded five new polar metabolites, which were identified as (25 R)-spirost-5-en-3β,7β,12β,25α-tetrol (2), (25 S)-spirost-5-en-3β,7α,12β,25β-tetrol (3), (25 S)-spirost-5-en-3β,7β,12β,25β-tetrol (4), (25 R)-spirost-5-en-3β,7α,12β,25α-tetrol (5), and (25 R)-spirost-5-en-3β,7β,12β,24β ...
Ying, Zhao +5 more
openaire +2 more sources
Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aβ-lowering modulators of amyloid precursor protein processing [PDF]
, 2016 published_or_final_versio
Cao, B +10 more
core +1 more source
Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
Oxidative Medicine and Cellular Longevity, 2022 Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting ...
Prabhakar Semwal +14 more
openaire +4 more sources
Fermentation, 2023 Diosgenin, a hydrolysis product from Dioscorea plants, can be used as a precursor of steroid drugs (e.g., progesterone, testosterone, and glucocorticoid).
Fangyuan Mou +9 more
doaj +1 more source
Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 [PDF]
, 2016 Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane- associated receptor, which has been discovered as the ...
Altieri, Fabio +7 more
core +1 more source
Protective Effect of Diosgenin against H2O2-Induced Oxidative Stress on H9C2 Cells [PDF]
Journal of Cell and Molecular Research, 2016 Diosgenin is an important compound in pharmaceutical industry. It has various effects such as hypocholesterolemic action or antioxidant activity in HIV infected patients. Biological oxidation pathways are involved in causing or aggravating heart disease.
Samaneh Jamshidi +5 more
doaj +1 more source
Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review
Phytotherapy Research, EarlyView.ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley +1 more source
High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion [PDF]
, 2018 Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity.
Alganga, Husam +9 more
core +2 more sources
Tetrazine Functionalized Graphene Enables Capture of Ultra‐Low Concentrations of Biomacromolecules
Small, EarlyView.A novel method for covalent modification of monolayer graphene utilizing tetrazine containing diazonium salt is demonstrated. The modified graphene bearing tetrazine moieties undergoes inverse electron demand Diels‐Alder reactions with trans‐cyclooctene‐linked molecules, enabling bioorthogonal attachment of nanobodies that selectively capture EGFP ...
Ravindra K. Gupta +4 more
wiley +1 more source
Pharmaceuticals, 2021 Steroidal saponins are widely used as starting precursors and medical intermediates for the semi-/total-synthesis of hundreds of steroidal drugs. One such steroidal saponin is diosgenin, which has attracted significant attention due to the huge market ...
Wancang Liu +7 more
doaj +1 more source