Results 31 to 40 of about 501 (137)
Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa
The FEBS Journal, EarlyView.Cryo‐EM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from Rhizobium homologues. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent micelle and nanodisc, relative to the membrane.
Shaileshanand Jha, Kutti R. Vinothkumar
wiley +1 more source
HPTLC determination of diosgenin in fenugreek seeds
Acta Pharmaceutica, 2018 Abstract A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions for efficient saponin extraction and acid hydrolysis. Several procedures were tested, the best of which was a three-step Soxhlet extraction, followed by hydrolysis of the ...
Król-Kogus Barbara +4 more
openaire +4 more sources
Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in a rat model
Scientific Reports, 2021 In a mouse model of Graves’ disease (GD), diosgenin has been shown to have a therapeutic effect on GD by alleviating goitre. However, research on the effect of diosgenin on autoimmune thyroiditis (AIT) is lacking.
Chengfei Zhang +6 more
doaj +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy +3 more
wiley +1 more source
Pharmaceuticals, 2021 Steroidal saponins are widely used as starting precursors and medical intermediates for the semi-/total-synthesis of hundreds of steroidal drugs. One such steroidal saponin is diosgenin, which has attracted significant attention due to the huge market ...
Wancang Liu +7 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 8, August 2026.The 80% ethanolic extract of Stachys germanica L. exhibited a phenolic‐rich phytochemical profile characterized by chlorogenic acid, naringin, luteolin, and kaempferol. The extract demonstrated notable antioxidant capacity, selective tyrosinase and α‐glucosidase inhibition, and significant antibacterial activity against Acinetobacter baumannii ATCC ...
Gözde Gülin İnan +8 more
wiley +1 more source
TfWRKY40 positively regulates diosgenin biosynthesis in Trigonella foenum-graecum L.
Frontiers in Plant ScienceDiosgenin is a bioactive steroidal natural product extraced from plants and serves as an important precursor for the industrial production of steroidal hormone drugs.
Chuanjia Xu +6 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aim The present systematic review and meta‐analysis aimed to investigate the effect of fenugreek supplementation on key liver enzymes, including alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
Mohsen Mohit +4 more
wiley +1 more source
Phenolic composition and multi‐target bioactivities of Globularia alypum extracts across seasons
JSFA reports, Volume 6, Issue 8, Page 314-330, August 2026.Abstract Background This study investigates the influence of seasonal variation on the phytochemical profile and biofunctional activities of ethanolic leaf extracts from Globularia alypum. Leaves collected across four seasons were extracted with a hydroethanolic solvent (80:20, v/v) and analyzed by LC‐ESI‐MS/MS.
Mohammed Messaoudi +11 more
wiley +1 more source
An update on the biological and pharmacological activities of diosgenin
EXCLI journal, 2018 EXCLI Journal;Vol.
Kim, Jae Kwang, Park, Sang Un
openaire +3 more sources