Results 51 to 60 of about 501 (137)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study

Science Progress
Objective This prospective study evaluated the therapeutic efficacy of Diosgenin in mitigating Oxazolone-induced ulcerative colitis in male BALB/c mice.
Ashwini Narayan, Priya Babu Shubha, Syed Baker, Niranjan Raj Sathyanarayana, Faiyaz Ahmed, Nanjunda Swamy Shivananju   +5 more
doaj   +1 more source

Ligand‐Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16INK4a‐Dependent Endothelial Senescence Associated With Atherosclerosis

Aging Cell, Volume 25, Issue 6, June 2026.
CTSL activates Notch1/RBPJ in a ligand‐independent fashion, inducing CUX1/p16INK4a‐dependent endothelial senescence associated with atherosclerosis. ABSTRACT Our post‐GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16INK4a‐dependent and atherosclerosis‐associated senescence by indirectly ...
Yuwei Wu, Lili Lu, Shaoyang Yan, Zewen Du, Danli Jiang, Ting Wu, Qichao Wu, Jie Liu, Johny Ebin, Wei Sun, Partha Dutta, Jay Xiaojun Tan, Jonathan K. Alder, Gang Li   +13 more
wiley   +1 more source

De Novo Transcriptome Sequencing in Trigonella foenum-graecum L. to Identify Genes Involved in the Biosynthesis of Diosgenin

The Plant Genome, 2013
T L. (fenugreek) is a viable alternative for production of diosgenin because of its shorter growing cycle, lower production costs, and consistent yield and quality.
Kanak Vaidya, Arpita Ghosh, Vinay Kumar, Spandan Chaudhary, Navin Srivastava, Kalpesh Katudia, Tanushree Tiwari, Surendra K. Chikara   +7 more
doaj   +1 more source

Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200 
Amal Elrherabi, Oussama Khibech, Mohamed Bouhrim, Abdelouahid Laftouhi, Abdelaaty A. Shahat, Abdullah R. Alanzi, Rashed N. Herqash, Joe Miantezila Basilua, Mohamed Bnouham   +8 more
wiley   +1 more source

Tetrazine Functionalized Graphene Enables Capture of Ultra‐Low Concentrations of Biomacromolecules

Small, Volume 22, Issue 28, 18 May 2026.
A novel method for covalent modification of monolayer graphene utilizing tetrazine containing diazonium salt is demonstrated. The modified graphene bearing tetrazine moieties undergoes inverse electron demand Diels‐Alder reactions with trans‐cyclooctene‐linked molecules, enabling bioorthogonal attachment of nanobodies that selectively capture EGFP ...
Ravindra K. Gupta, Hanbin Jeong, April Goehring, Eric Gouaux, Maggie He   +4 more
wiley   +1 more source

LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 739-750, May 2026.
LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang, Zixu Huang, Xiaohui Kuang, Yali Nan, Zhiwen Zhang, Zongming Song   +5 more
wiley   +1 more source