Results 51 to 60 of about 5,720 (220)

Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8

, 2005
The plant sterol diosgenin has been shown to stimulate biliary cholesterol secretion in mice without affecting the expression of the adenosine triphosphate-binding cassette transporter heterodimer Abcg5/g8.
Patel, Shailendra B., Kunne, Cindy, Vink, Edwin, Nibbering, Catherina P., Frijters, Raoul J. J. M., Kosters, Astrid, Schneiders, Marit S., Schaap, Frank G., Groen, Albert K.   +8 more
core   +1 more source

Screening and Selection of a New Medium and Culture Conditions for Diosgenin Production via Microbial Biocatalysis of SYt1

Bioengineering
Diosgenin (DSG) is a phytosterol saponin mainly found in Dioscorea zingiberensis C.H. Wright. It has shown promising results in treating various diseases such as cancer, diabetes, arthritis, asthma, and cardiovascular diseases.
Shiyao Han, Yiyu Zhao, Fangyuan Mou, Zhen Yang, Ningxiao Li, Mengqi Cheng, Heshaungyi Xie, Baofu Qin, Young Tang   +8 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Validation of a method for diosgenin extraction from fenugreek (Trigonella foenum-graecum L.) [PDF]

, 2018
Background. Diosgenin is a very important plant secondary metabolite and raw material for the drug industry. Plant sources rich in diosgenin include yam (Dioscorea spp.) and fenugreek (Trigonella foenum-graecum L.). A method for diosgenin extraction from
Vitalini S., Syed B. A., Iriti M., Bagali P. G., Chaudhary S. A., Chaudhary P. S., Misra R.   +6 more
core   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Dioscorea Belizensis Lundell as A Source of Diosgenin

Journal of Pharmacy and Pharmacology, 1963
Abstract Twenty-nine species of wild Dioscorea from British Honduras were screened for saponins. The tubers of D. belizensis Lundell afforded yields of steroids of about 2 per cent of the dry weight, calculated as the acetate of the predominant genin, diosgenin.
G, BLUNDEN, R, HARDMAN
openaire   +2 more sources

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology [PDF]

Journal of Analytical Methods in Chemistry, 2016
Diosgenin, a steroidal sapogenin, occurs abundantly in plants such asDioscorea alata,Smilax China,andTrigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment ...
Mafalda Jesus, Ana P. J. Martins, Eugenia Gallardo, Samuel Silvestre   +3 more
openaire   +4 more sources

Comparative Transcriptome Analysis Identifies Genes Involved in Diosgenin Biosynthesis in Trigonella foenum-graecum L.

Molecules, 2019
Trigonella foenum-graecum L. (fenugreek) is a valuable resource of producing diosgenin which serves as a substrate for synthesizing more than two hundred kinds of steroidal drugs.
Chen Zhou, Xiaohua Li, Zilin Zhou, Changfu Li, Yansheng Zhang   +4 more
doaj   +1 more source

In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity

, 2015
Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity.
Jing-Hsien Chen, Chih-Tai Chen, Hui-Hsuan Lin, Zhi-Hong Wang, Cheng-Chin Hsu   +4 more
core   +1 more source