Results 61 to 70 of about 9,241 (226)

Oral administration of diosgenin protects optic nerve degeneration in a mouse model of normal-tension glaucoma

open access: yesPhytomedicine Plus
Introduction: In glaucoma, degeneration of visual pathway spread whole brain area, suggesting that restoring the degenerated axons in the whole visual pathway is crucial for vision recovery.
Chihiro Tohda, Shogo Shibue
doaj   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

open access: yesChemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy   +4 more
wiley   +1 more source

Comparative Transcriptome Analysis Identifies Genes Involved in Diosgenin Biosynthesis in Trigonella foenum-graecum L.

open access: yesMolecules, 2019
Trigonella foenum-graecum L. (fenugreek) is a valuable resource of producing diosgenin which serves as a substrate for synthesizing more than two hundred kinds of steroidal drugs.
Chen Zhou   +4 more
doaj   +1 more source

Entwicklung alternativer Zusatzstoffe für Bioprodukte, die der Verbesserung von Mehlmischungen für Back- und Teigwaren dienen, durch die Verwendung der Yamswurzel Dioscorea batatas [PDF]

open access: yes, 2011
Ziel des Projektes ist die Entwicklung ökologischer Zutaten aus der Yamswurzel Dioscorea batatas. Durch die Verwendung der D. batatas können Mehlmischungen in ihren sensorischen, physiologischen und gesundheitlichen Eigenschaften aufgewertet werden.
Hensel, Oliver
core  

Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. [PDF]

open access: yesPeerJ
Dioscorea cirrhosa L. (D. cirrhosa) tuber is a traditional medicinal plant that is abundant in various pharmacological substances. Although diosgenin is commonly found in many Dioscoreaceae plants, its presence in D. cirrhosa remained uncertain.
Yan Lin   +6 more
doaj   +2 more sources

The Biochemical Role of Bitter Melon (Momordica charantia L.) Aqueous Extract in Regulating Hepatic Gluconeogenesis in Rats Fed Ketogenic Diet

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Metabolic effects of a ketogenic diet and bitter melon extract on hepatic gluconeogenesis and glucose–lipid homeostasis. ABSTRACT The ketogenic diet (KD) has been suggested as a useful lifestyle intervention for metabolic syndrome; however, its long‐term metabolic effects remain debated.
Ghalia Shamlan
wiley   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian   +8 more
wiley   +1 more source

A review on phytochemistry and pharmacological effects of Trigonella foenum-graecum [PDF]

open access: yes, 2016
Background and aims: Fenugreek (Trigonella foenum-graecum) is a medicinal plant with potential applications in the medicinal purposes. Fenugreek has been used in food as a flavouring agent since ancient times in many countries like Greece, Rome and Egypt.
Mahmood, Syed., Rebhi Hilles, Ayah.
core  

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua   +12 more
wiley   +1 more source

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

open access: yesNature Communications, 2019
Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical ...
Bastien Christ   +9 more
doaj   +1 more source

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