Results 61 to 70 of about 2,018 (130)

Unlocking the Hepatoprotective Potential of Urolithin A in High‐Fat Diet‐Induced MASLD: Integrated Role of Oxidative Stress, Inflammation, FXR/PPAR‐α, and Fibrotic Pathway

open access: yesCell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT “Metabolic dysfunction–associated steatotic liver disease” (MASLD) is marked by hepatic steatosis, oxidative stress, inflammation, and fibrosis. Urolithin A (Uro A), a metabolite of ellagitannins, exhibits anti‐inflammatory, antioxidant, and metabolic regulatory activities.
Hamad Alsaykhan   +9 more
wiley   +1 more source

Molecularly imprinted polymers for diosgenin

open access: yes, 2019
Diosgenin is steroid sapogenin used in therapies of many diseases such as breast cancer, cervix cancer, prostate cancer, certain forms of leukemia and in infertility therapy.
Pešić, Miloš   +3 more
core   +2 more sources

Natural Product‐Derived Vesicles in Nanotherapeutics

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Validation of a method for diosgenin extraction from fenugreek (Trigonella foenum-graecum L.) [PDF]

open access: yes, 2018
Background. Diosgenin is a very important plant secondary metabolite and raw material for the drug industry. Plant sources rich in diosgenin include yam (Dioscorea spp.) and fenugreek (Trigonella foenum-graecum L.). A method for diosgenin extraction from
Vitalini S.   +6 more
core   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan   +9 more
wiley   +1 more source

Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study

open access: yesScience Progress
Objective This prospective study evaluated the therapeutic efficacy of Diosgenin in mitigating Oxazolone-induced ulcerative colitis in male BALB/c mice.
Ashwini Narayan   +5 more
doaj   +1 more source

Evaluation of antigenotoxic effects of diosgenin in mice exposed to cyclophosphamide

open access: yes, 2018
Diosgenin is a steroidal saponin found in a variety of plants including fenugreek and roots of wild yam and is widely used in traditional medicine systems.
Subbarao D, Hema G, Thippeswamy BS
core   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

open access: yesPhytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy   +3 more
wiley   +1 more source

De Novo Transcriptome Sequencing in Trigonella foenum-graecum L. to Identify Genes Involved in the Biosynthesis of Diosgenin

open access: yesThe Plant Genome, 2013
T L. (fenugreek) is a viable alternative for production of diosgenin because of its shorter growing cycle, lower production costs, and consistent yield and quality.
Kanak Vaidya   +7 more
doaj   +1 more source

Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa

open access: yesThe FEBS Journal, Volume 293, Issue 17, Page 5318-5339, September 2026.
Multiple peptide resistance factor (MprF) is a bacterial enzyme that carries out the aminoacylation of lipid head groups. CryoEM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from its homologues in Rhizobium. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent
Shaileshanand Jha, Kutti R. Vinothkumar
wiley   +1 more source

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