Results 61 to 70 of about 501 (137)

Effects of Diosgenin on Myometrial Matrix Metalloproteinase-2 and -9 Activity and Expression in Ovariectomized Rats

International Journal of Biological Sciences, 2011
Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ...
Chi-Chen Chang, Tang-Ching Kuan, Yao-Yuan Hsieh, Ying-Jui Ho, Yu-Ling Sun, Chih-Sheng Lin
doaj  

Exploring the anti-gastric cancer mechanisms of Diosgenin through integrated network analysis, bioinformatics, single-cell sequencing, and cell experiments

Frontiers in Pharmacology
BackgroundTo comprehensively investigate the mechanism of action of Diosgenin elements against gastric cancer (GC).MethodsTargets of Diosgenin were collected from six databases, and enrichment analysis was used to identify its associated diseases and ...
Zhangjun Yun, Zhangjun Yun, Qianru Yang, Qianru Yang, Chengyuan Xue, Chengyuan Xue, Yang Shen, Liyuan Lv, Suicai Mi, Li Hou   +9 more
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Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Nature Communications, 2019
Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical ...
Bastien Christ, Chengchao Xu, Menglong Xu, Fu-Shuang Li, Naoki Wada, Andrew J. Mitchell, Xiu-Lin Han, Meng-Liang Wen, Makoto Fujita, Jing-Ke Weng   +9 more
doaj   +1 more source

Insights into diosgenin against inflammatory bowel disease as functional food based on network pharmacology and molecular docking

Heliyon
Inflammatory bowel disease (IBD) is a growing global health problem. IBD is commonly prevalent in Europe and America and the incidence rate in Asia is on the rise due to altered dietary structure.
Min Cai, Yangchen Mao, Wenjing Gao, Zhenzhen Wang, Jianwei Mao, Ruyi Sha   +5 more
doaj   +1 more source

Diosgenin Production in North America [PDF]

HortTechnology, 1991
Diosgenin is a steroidal aglycone occurring in certain species of Dioscorea native principally to eastern Mexico. In the 1940s, diosgenin became a much-sought-after intermediate for the chemical synthesis of certain corticosteroids and structurally related fertility regulants.
openaire   +1 more source

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis

Scientific Reports
The prevalence of nonalcoholic steatohepatitis (NASH) is rising annually, posing health and economic challenges, with limited treatments available.
Peiyuan Gu, Juan Chen, Jingxin Xin, Huiqi Chen, Ran Zhang, Dan Chen, Yuhan Zhang, Shanshan Shao   +7 more
doaj   +1 more source

Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage

Journal of Lipid Research, 1999
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration.
Ludwig Amigo, Hegaly Mendoza, Silvana Zanlungo, Juan Francisco Miquel, Attilio Rigotti, Sergio González, Flavio Nervi   +6 more
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THE EFFECT OF SIMULTANEOUS APPLICATION OF NITROGEN AND COPPER ON YIELD AND STEROIDAL SAPOGENIN PRODUCTION IN Trigonella foenum graecum L.

Acta Scientiarum Polonorum: Hortorum Cultus, 2017
Diosgenin (a steroidal saponin of fenugreek) has long been used as a raw substance for the manufacturing of steroid drugs. In order to evaluate the nutritional effect of different nitrogen (0, 50, 100, 150 and 200 kg ha-1) and copper (0, 10, 20 and 30 ...
Mostafakamal Shams, Behzad Haghighi, Ertan Yildirim, Vali Rabiei, Sezai Ercisli, Sirus Masiha, Ahmad Golchin   +6 more
doaj  

Diosgenin from Solanum Species

, 1969
Diosgenin from Solanum ...
Sipra Mookherjea, Rabecca Mathew
openaire   +2 more sources

Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study

BMC Plant Biology
Background Diosgenin is an important steroidal precursor renowned for its diverse medicinal uses. It is predominantly sourced from Dioscorea species, particularly Dioscorea zingiberensis.
Shi xian Sun, Yanmei Li, Lu Jia, Shili Ye, Yunpeng Luan   +4 more
doaj   +1 more source