Results 71 to 80 of about 501 (137)

Predicting the potential global distribution of diosgenin-contained Dioscorea species

Chinese Medicine, 2018
Background Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological damage, wild Dioscorea species
Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li, Shilin Chen   +6 more
doaj   +1 more source

Exploring the role of diosgenin in modulating RUNX1 and HIPK2 transcription to mitigate Primary Sjögren's Syndrome

Immunobiology
Background: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune disease characterized by inflammation of the exocrine glands, resulting in symptoms like dry mouth and eyes.
Yiwei Pan, Lunquan Wei, Han Liu, Fang Wang, Minhua Wang, Meijia Li, Pengfei Cheng, Xing Yan   +7 more
doaj   +1 more source

Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase.

PLoS ONE, 2014
Diabetes mellitus is a multifactorial metabolic disease characterized by post-prandial hyperglycemia (PPHG). α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic agents.
Sougata Ghosh, Piyush More, Abhishek Derle, Ajay B Patil, Pramod Markad, Adersh Asok, Navanath Kumbhar, Mahemud L Shaikh, Boppana Ramanamurthy, Vaishali S Shinde, Dilip D Dhavale, Balu A Chopade   +11 more
doaj   +1 more source

Diosgenin fromAllium albidum [PDF]

Chemistry of Natural Compounds, 1970
E. V. Kereselidze, T. A. Pkheidze, É. P. Kemertelidze   +2 more
openaire   +1 more source

Microbial metabolism of diosgenin by a novel isolated Mycolicibacterium sp. HK‐90: A promising biosynthetic platform to produce 19‐carbon and 21‐carbon steroids

Microbial Biotechnology
Green manufacture of steroid precursors from diosgenin by microbial replacing multistep chemical synthesis has been elusive. It is currently limited by the lack of strain and degradation mechanisms.
Zhikuan Wang, Hailiang Qiu, Yulong Chen, Xuemin Chen, Chunhua Fu, Longjiang Yu   +5 more
doaj   +1 more source

Role of diosgenin extracted from Helicteres isora L in suppression of HIV-1 replication: An in vitro preclinical study

Heliyon
Background: Diosgenin, an essential sapogenin steroid with significant biological implications, is composed of a hydrophilic sugar moiety intricately linked to a hydrophobic steroid aglycone.
Smita Rakshit, Ashwini More, Shraddha Gaikwad, Chandrabhan Seniya, Aniket Gade, Vijaykumar Yogesh Muley, Anupam Mukherjee, Kapil Kamble   +7 more
doaj   +1 more source

The antioxidant activity of diosgenin, a plant steroid sapogenin, in C2C12 myoblasts is achieved by blocking mitochondrial ROS production

Applied Biological Chemistry
Diosgenin, a plant-derived steroid sapogenin, has been reported to have many health benefits, including antioxidant activity. Although oxidative stress is a major factor impeding the differentiation and homeostasis of skeletal muscles, its antioxidant ...
Cheol Park, Gi-Young Kim, Yung Hyun Choi
doaj   +1 more source

Diosgenin reverses posttraumatic stress disorder in mice by augmenting neurochemical release and inhibiting HPA axis dysfunction, oxidative stress, and neuroinflammation

Journal of Affective Disorders Reports
Post-traumatic stress disorder (PTSD) is a mental disorder linked to neurochemical, hypothalamic-pituitary-adrenal (HPA)-axis dysregulations, inflammatory and pro-oxidant challenges in response to traumatic events.
Benneth Ben-Azu, Olusegun G. Adebayo, Adaeze Adebesin, Kenneth C. Oparaji, Vivian O. Ojiakor, Gift C. Pender, Bensandy O. Odeghe, Noah A. Omeiza, Halimat A. Abdulrahim, Vivian Ezieshi, Glory Ighosotu, Emmanuel Omo-Odudu, Ekene I. Monye   +12 more
doaj   +1 more source

Molecularly imprinted polymers for diosgenin [PDF]

, 2019
Diosgenin is steroid sapogenin used in therapies of many diseases such as breast cancer, cervix cancer, prostate cancer, certain forms of leukemia and in infertility therapy. Diosgenin is a precursor for production of other significant steroidal compounds such as dehydroepiandrosterone [1].
Ugrinov, Stefan, Đurđević, Mladen, Todorov, Miljana, Pešić, Miloš   +3 more
openaire  

Containment of neuroimmune challenge by diosgenin confers amelioration of neurochemical and neurotrophic dysfunctions in ketamine-induced schizophrenia in mice

Brain Disorders
Inhibition of neuroinflammation through N-methyl-D-aspartate receptor (NMDAR) regulation can provide normalization of neurochemical homeostasis and neurotrophic support in the pathogenesis of psychiatric disorders with complex symptoms such as ...
Benneth Ben-Azu, Olusegun G. Adebayo, Aliance R. Fokoua, Jackson E. Onuelu, Jerome N. Asiwe, Emuesiri G. Moke, Itivere A. Omogbiya, Oghenemarho L. Okpara, Jennifer E. Okoro, Omadevuaye M. Oghenevwerutevwe, Christian I. Uruaka   +10 more
doaj   +1 more source