Results 81 to 90 of about 501 (137)

Diosgenin: A Potential Therapeutic Phytocompound for the Management of Atherosclerosis and Other Physiological Disorders

Natural Product Communications
The present study is aimed to explore the therapeutic attributes of diosgenin against atherosclerosis and associated health disorder. Side effects associated with synthetic drugs for the treatment and management of diseases worldwide have necessitated ...
Rizwan ur-Rehman, Sania Riaz, Misha Arooj, Saleha Khan, Urwa Tariq, Maliha Fatima   +5 more
doaj   +1 more source

Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.)

Journal of Medicinal Plants, 2010
Fenugreek (Trigonella foenum-graecum L.) has a long and respected history of medicinal uses in Middle East and Persian medicine. The hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin ...
A Mehrafarin, A Qaderi, Sh Rezazadeh, H Naghdi Badi, Gh Noormohammadi, E Zand   +5 more
doaj  

Extraction techniques, mechanistic insights for gut health, microbiota modulation, and industrial applications of diosgenin

Discover Chemistry
Background Diosgenin is a steroidal saponin of Dioscorea and Trigonella species, which has been gaining a lot of interest due to its health-promoting action.
Tayyaba Rao, Asad Abbas, Muhammad Bilal, Hassan Shabbir, Muhammad Naeem Zubairi, Ashiq Hussain, Abdeen Elsiddig Elkhedir   +6 more
doaj   +1 more source

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Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells

European Journal of Pharmacology, 2020
(25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent. However, the relationship between DSG glycosides and apoptotic, necrotic, and antiproliferative activity remains unclear.
José Misael Vicente, Hernández-Vázquez, Hugo, López-Muñoz, María Luisa, Escobar-Sánchez, Fernando, Flores-Guzmán, Benny, Weiss-Steider, Jazmin Ciciolil, Hilario-Martínez, Jesús, Sandoval-Ramírez, María A, Fernández-Herrera, Luis, Sánchez Sánchez   +8 more
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Stability of Diosgenin

Journal of Pharmaceutical Sciences, 1968
The decomposition of 25α-Δ 5 -spirosten-3β-ol (diosgenin) has been studied by various physical techniques in the solid state, in contact with both 2 N hydrochloric acid and 2 N sodium carbonate solution, and in solution in both chloroform and benzene.
G, Blunden, C T, Rhodes
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Biosynthesis of diosgenin in Dioscorea tubers

Archives of Biochemistry and Biophysics, 1961
Abstract The incorporation of radioacetate into diosgenin by homogenates of Dioscorea floribunda has been demonstrated by rigorous purification of the isolated sapogenin. Mevalonic acid is not incorporated into diosgenin to any significant extent under these conditions.
E, HEFTMANN, R D, BENNETT, J, BONNER
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Effect of diosgenin on cholesterol metabolism

Journal of Atherosclerosis Research, 1962
Summary In chickens fed a stock diet with 2 % cholesterol, the addition of 0.2–2.0 % diosgenin ( Δ 5 -22 ɛ -spirosten-3 β -ol) prevented the resulting hypercholesterolemia. Animals were followed up from 22 to 100 days and at the end of the experimental period, serum cholesterol values averaged about 110–180 mg% in control animals, 700–850 mg% in the ...
J, LAGUNA, A, GOMEZ-PUYOU, A, PENA, J, GUZMAN-GARCIA   +3 more
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Microbial modification of diosgenin and hecogenin

Journal of the Chemical Society, Perkin Transactions 1, 1973
On incubation with an unidentified bacterium diosgenin [(25R)-spirost-5-en-3β-ol](1) was converted into (25R)-9-oxode-AB-spirostane-8α-propionic acid (3). Incubation with Nocardia globerula produced the same oxo-acid (3) and also a small amount of its 1 7α-hydroxy-derivative.
R, Howe, R H, Moore, B S, Rao, D T, Gibson   +3 more
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The role of diosgenin in diabetes and diabetic complications

The Journal of Steroid Biochemistry and Molecular Biology, 2020
Diabetes mellitus is a chronic and common metabolic disease that seriously endangers human health. Hyperglycemia and long-term metabolic disorders in diabetes will cause damage to the whole body tissues and organs, resulting in serious complications. Nowadays, drugs for treating diabetes on the market has strong side effects, new treatments thus are ...
Qingxia, Gan, Jin, Wang, Ju, Hu, Guanhua, Lou, Haijun, Xiong, Chengyi, Peng, Song, Zheng, Qinwan, Huang   +7 more
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Cardiovascular Effect of Diosgenin in Ovariectomized Rats

Journal of Medicinal Food, 2019
Diosgenin is a phytoestrogen and a constituent of Dioscorea . It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat ...
Ilmara Cecilia Pinheiro de Silva, Morais, Iris Jordânia Luz, Moura, Carla Kelly Barroso, Sabino, Lucas Antonio Duarte, Nicolau, Fabiana de Moura, Souza, José Couras da, Silva-Filho, Rita de Cássia Meneses, Oliveira, Jand Venes Rolim, Medeiros, Sidney Gonçalo de, Lima, Aldeidia Pereira de, Oliveira   +9 more
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