Results 81 to 90 of about 2,018 (130)

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Nature Communications, 2019
Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical ...
Bastien Christ, Chengchao Xu, Menglong Xu, Fu-Shuang Li, Naoki Wada, Andrew J. Mitchell, Xiu-Lin Han, Meng-Liang Wen, Makoto Fujita, Jing-Ke Weng   +9 more
doaj   +1 more source

Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage

Journal of Lipid Research, 1999
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration.
Ludwig Amigo, Hegaly Mendoza, Silvana Zanlungo, Juan Francisco Miquel, Attilio Rigotti, Sergio González, Flavio Nervi   +6 more
doaj   +1 more source

Molecular characterization of diosgenin biosynthesis in different organs of Trigonella foenum-graecum L. [PDF]

Fenugreek, an annual herb, is a significant source of diosgenin, a triterpene with bioactive properties. This study aimed to molecularly characterize diosgenin biosynthesis in various organs of fenugreek, including flowers, immature leaves, developing ...
Kim, Jae Kwang, Kwon, Do Yeon, Uddin, Md. Romij, Park, Sang Un, Sathasivam, Ramaraj, Lim, Jinsu   +5 more
core   +1 more source

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis

Scientific Reports
The prevalence of nonalcoholic steatohepatitis (NASH) is rising annually, posing health and economic challenges, with limited treatments available.
Peiyuan Gu, Juan Chen, Jingxin Xin, Huiqi Chen, Ran Zhang, Dan Chen, Yuhan Zhang, Shanshan Shao   +7 more
doaj   +1 more source

THE EFFECT OF SIMULTANEOUS APPLICATION OF NITROGEN AND COPPER ON YIELD AND STEROIDAL SAPOGENIN PRODUCTION IN Trigonella foenum graecum L.

Acta Scientiarum Polonorum: Hortorum Cultus, 2017
Diosgenin (a steroidal saponin of fenugreek) has long been used as a raw substance for the manufacturing of steroid drugs. In order to evaluate the nutritional effect of different nitrogen (0, 50, 100, 150 and 200 kg ha-1) and copper (0, 10, 20 and 30 ...
Mostafakamal Shams, Behzad Haghighi, Ertan Yildirim, Vali Rabiei, Sezai Ercisli, Sirus Masiha, Ahmad Golchin   +6 more
doaj  

Pharmacological characteristics of a phyto steroidal food saponin: Diosgenin

, 2020
Diosgenin, a plant derived steroidal saponin found most abundantly in legumes and yams. It has been used for the treatment of various types of disorder such as leukemia, inflammation, hypercholesterolemia and cancer. Besides being a lactation aid, it has
S. Mirunalini, V. Manobharathi
core   +1 more source

Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study

BMC Plant Biology
Background Diosgenin is an important steroidal precursor renowned for its diverse medicinal uses. It is predominantly sourced from Dioscorea species, particularly Dioscorea zingiberensis.
Shi xian Sun, Yanmei Li, Lu Jia, Shili Ye, Yunpeng Luan   +4 more
doaj   +1 more source

Predicting the potential global distribution of diosgenin-contained Dioscorea species

Chinese Medicine, 2018
Background Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological damage, wild Dioscorea species
Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li, Shilin Chen   +6 more
doaj   +1 more source

Clemmensen reduction of diosgenin and kryptogenin: synthesis of [16,16,22,22,23,23-H-2(6)]-(25R)-26-hydroxycholesterol.

, 2004
A new experimental protocol has been established for the Clemmensen reduction of diosgenin and kryptogenin with the aim to prepare deuterated isotopomers of (25R)-26-hydroxycholesterol.
E. Santaniello, G. Terraneo, P. Ciuffreda, L. Alessandrini   +3 more
core   +1 more source

Exploring the role of diosgenin in modulating RUNX1 and HIPK2 transcription to mitigate Primary Sjögren's Syndrome

Immunobiology
Background: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune disease characterized by inflammation of the exocrine glands, resulting in symptoms like dry mouth and eyes.
Yiwei Pan, Lunquan Wei, Han Liu, Fang Wang, Minhua Wang, Meijia Li, Pengfei Cheng, Xing Yan   +7 more
doaj   +1 more source