Results 81 to 90 of about 5,720 (220)

Diosgenin via NMDA Receptor Exerted Anxiolytic-like Effect in Maternally Separated Mice

, 2020
Background and aim: Anxiety is one of the most common psychiatric disorders that lead to disruption of daily and quality of life. Routine medications have many side effects and cause physical dependence and psychosocial addiction.
Boroujeni, Shakiba Nasiri, Amini-Khoei, Hossein, Boldaji, Fatemeh Rahimi, Lorigooini, Zahra   +3 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Diosgenin production in Trigonella foenum-graecum (Fenugreek) cell cultures in response to yeast extract elicitation

, 2021
© 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.Diosgenin is an important precursor of steroidal drugs and a number of biotechnology techniques, including gene transfer and elicitation studies, are used to ...
ÖZDEN, Sibel, İlgar, Bekir Ahmet, TURGUT KARA, Neslihan, ÇEPNİ YÜZBAŞIOĞLU, Fatma Elif   +3 more
core   +1 more source

Diosgenin does not express estrogenic activity: a uterotrophic assay

, 2014
This study assessed the effects of diosgenin on estrogenic activity using a uterotrophic assay. Immature female rats received diosgenin orally at doses of 200, 100, or 20 mg/kg body mass; and 17 alpha ethynylestradiol at doses of 1 or 0.3 mu g ...
Medigovic, Ivana, Filipović, Branko, Milošević, Verica, Zivanovic, Jasmina, Šošić-Jurjević, Branka, Nestorović, Nataša, Ristić, Nataša, Jarić, Ivana   +7 more
core   +1 more source

Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage

Journal of Lipid Research, 1999
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration.
Ludwig Amigo, Hegaly Mendoza, Silvana Zanlungo, Juan Francisco Miquel, Attilio Rigotti, Sergio González, Flavio Nervi   +6 more
doaj   +1 more source

An HD-ZIP I Transcription Factor DZHDZ32 Upregulates Diosgenin Biosynthesis in <i>Dioscorea zingiberensis</i>. [PDF]

Int J Mol Sci
Diosgenin, a crucial precursor for steroidal drug production, has poorly understood regulatory pathways. Diosgenin is the primary active component of Dioscorea zingiberensis. Notably, D.
Yang H, Li Y, Hu Z, Li J.
europepmc   +2 more sources

Diosgenin Production in North America [PDF]

HortTechnology, 1991
Diosgenin is a steroidal aglycone occurring in certain species of Dioscorea native principally to eastern Mexico. In the 1940s, diosgenin became a much-sought-after intermediate for the chemical synthesis of certain corticosteroids and structurally related fertility regulants.
openaire   +1 more source

Crescimento in vitro, aclimatização e conteúdo de diosgenina de diferentes somaclones de Dioscorea composita Hemsl. (Dioscoreaceae) [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.
Costa, Talía da
core  

Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study

BMC Plant Biology
Background Diosgenin is an important steroidal precursor renowned for its diverse medicinal uses. It is predominantly sourced from Dioscorea species, particularly Dioscorea zingiberensis.
Shi xian Sun, Yanmei Li, Lu Jia, Shili Ye, Yunpeng Luan   +4 more
doaj   +1 more source

Insights into diosgenin against inflammatory bowel disease as functional food based on network pharmacology and molecular docking

Heliyon
Inflammatory bowel disease (IBD) is a growing global health problem. IBD is commonly prevalent in Europe and America and the incidence rate in Asia is on the rise due to altered dietary structure.
Min Cai, Yangchen Mao, Wenjing Gao, Zhenzhen Wang, Jianwei Mao, Ruyi Sha   +5 more
doaj   +1 more source