Results 91 to 100 of about 501 (137)

Novel effects of diosgenin on skin aging

Steroids, 2009
Extracts of Dioscorea coomposita or Dioscorea villosa are consumed as supplemental health foods at the time of climacteric. The extracts contain large amounts of the plant steroid, diosgenin. Here, we studied the safety and efficacy of diosgenin against skin aging at the time of climacteric. In vitro, diosgenin enhanced DNA synthesis in a human 3D skin
Yayoi, Tada, Naoko, Kanda, Akinori, Haratake, Megumi, Tobiishi, Hideyo, Uchiwa, Shinichi, Watanabe   +5 more
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Isolation of diosgenin by microbiological hydrolysis of saponin

Archives of Biochemistry and Biophysics, 1955
Abstract By microbial hydrolysis the saponins in pulverized Dioscorea tuber have been cleaved into the component parts, diosgenin and the sugar moieties. In one case a derivative, Δ 4 -diosgenone, was isolated. Although a wide range of conditions may be used in this conversion, the simplest include a mixed culture fermentation of pulverized fresh ...
J W, ROTHROCK, T H, STOUDT, J D, GARBER
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Effects of diosgenin and its derivatives on atherosclerosis

Food & Function, 2019
The effects of diosgenin are discussed with respect to endothelial dysfunction, lipid profile, macrophage foam cell formation, VSMC viability, thrombosis and inflammation during the formation of atherosclerosis.
Fang-Chun Wu, Jian-Guo Jiang
openaire   +2 more sources

Advances in the pharmacological activities and mechanisms of diosgenin

Chinese Journal of Natural Medicines, 2015
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions.
Yan, Chen, You-Mei, Tang, Su-Lan, Yu, Yu-Wei, Han, Jun-Ping, Kou, Bao-Lin, Liu, Bo-Yang, Yu   +6 more
openaire   +2 more sources

Investigation on the mechanisms for biotransformation of saponins to diosgenin

World Journal of Microbiology and Biotechnology, 2013
In order to improve the efficiency of biotransformation of saponins in Dioscorea zingiberensis to diosgenin, a new enzymatic model was developed to investigate the mechanism of the metabolic systems. Four main saponin hydrolases (E1, E2, E3 and E4) were purified from Trichoderma reesei.
Yuling, Zhu, Hancan, Zhu, Muqing, Qiu, Tingting, Zhu, Jinren, Ni   +4 more
openaire   +2 more sources

Solubility of diosgenin in different solvents

The Journal of Chemical Thermodynamics, 2012
Abstract The solubility of diosgenin in methanol, ethanol (95%), isopropanol, acetone, acetic ether, and propyl acetate were measured at temperatures from (295.15 to 330.15) K using the synthetic method by a laser monitoring observation technique at atmospheric pressure.
Fei-xiong Chen, Ming-rui Zhao, Bao-zeng Ren, Cai-rong Zhou, Fei-fei Peng   +4 more
openaire   +1 more source

Chemodifferentiation of diosgenin in Dioscorea composita

Phytochemistry, 1984
Abstract Diosgenin was isolated from different parts of a three-year-old plant of Dioscorea composite . The amounts (% on a dry wt basis) present were: tubers, 3.6; vine internodes and nodes with their leaves from first 20 nodes from the tubers, 1.6; similarly from intermediate 20 nodes, 0.039 and from upper 20 nodes, 0.03.
S.K. Datta, Karabi Datta
openaire   +1 more source

Process optimization for the production of diosgenin with Trichoderma reesei

Bioprocess and Biosystems Engineering, 2009
Based on the response surface methodology, an effective microbial system for diosgenin production from enzymatic pretreated Dioscorea zingiberensis tubers with Trichoderma reesei was studied. The fermentation medium was optimized with central composite design (3(5)) depended on Plackett-Burmann design which identified significant impacts of peptone, K ...
Yuling, Zhu, Jinren, Ni, Wen, Huang
openaire   +2 more sources

Meiosis activating sterols derived from diosgenin

Bioorganic & Medicinal Chemistry Letters, 2002
Continuing research based on the meiosis activation properties of the endogenous sterol FF-MAS is reported. The synthesis and SAR of 16- and 26-substituted sterols are described, utilising diosgenin as starting material. Selected sterols were tested for their ability to induce oocyte maturation in hypoxanthine arrested mouse oocytes in vitro.
Anthony, Murray, Christian, Grøndahl, Jan L, Ottesen, Peter, Faarup   +3 more
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Therapeutic effects of diosgenin in experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2017
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system. Currently, there is no drug available to cure this kind of disease. Diosgenin is a plant-derived steroid saponin. A previous study in our lab revealed that diosgenin can promote oligodendrocyte progenitor cell differentiation and accelerate ...
Weili Liu, Mei Zhu, Zhongwang Yu, Dou Yin, Fengfeng Lu, Yingyan Pu, Chao Zhao, Cheng He, Li Cao   +8 more
openaire   +2 more sources