Results 91 to 100 of about 5,720 (220)

Fenugreek derived diosgenin as an emerging source for diabetic therapy [PDF]

Diabetes is a chronic metabolic disease that endangers the entire body’s tissues and organs. Diabetes impairs glucose and insulin regulation in the human body by causing pancreatic cell damage.
Manpreet Kaur, Chiranjeev Kumawat, Abhishek Chitranashi, Manoj Bali, Yamini Tak, Mahesh Kumar Samota, Preeti Verma   +6 more
core   +1 more source

THE EFFECT OF SIMULTANEOUS APPLICATION OF NITROGEN AND COPPER ON YIELD AND STEROIDAL SAPOGENIN PRODUCTION IN Trigonella foenum graecum L.

Acta Scientiarum Polonorum: Hortorum Cultus, 2017
Diosgenin (a steroidal saponin of fenugreek) has long been used as a raw substance for the manufacturing of steroid drugs. In order to evaluate the nutritional effect of different nitrogen (0, 50, 100, 150 and 200 kg ha-1) and copper (0, 10, 20 and 30 ...
Mostafakamal Shams, Behzad Haghighi, Ertan Yildirim, Vali Rabiei, Sezai Ercisli, Sirus Masiha, Ahmad Golchin   +6 more
doaj  

Effects of diosgenin on phosphorylation of PI3K and Akt.

, 2013
PC-3 cells were treated with various doses of diosgenin for 24 h (A), or 20 µM of diosgenin for 3, 6, 12, 18 and 24 h (B). The phosphorylation of PI3K and Akt was determined by SDS-PAGE and Western blotting. β-actin was used as a loading control.
Hsiang-Ching Huang (351028), Pin-Shern Chen (351026), Hsing-Wen Cheng (351029), Yuan-Wei Shih (351027)   +3 more
core   +1 more source

DIOSGENIN DETERMINATION OF Costus speciosus WATER EXTRACT USING HPLC METHOD

, 2017
Costus speciosus has been reported to have biological activity among antidiabetic, antihyperlipidemia, antioxidants. One of the chemical constituents that is responsible for some of the biological activity is diosgenin.
Susanti, Hari, Sari, Ika Puspita, Subagus Wahyuono, Ratna Asmah Susidarti, Hari Susanti, Susidarti, Ratna Asmah, Ika Puspita Sari, Wahyuono, Subagus   +7 more
core   +1 more source

Az endothelfunkció farmakológiai befolyásolhatósága korai stádiumú metabolikus szindrómában

, 2018
Hazánkban és más országokban is nagy gyakorisággal fordulnak elő életmóddal összefüggő metabolikus zavarok, köztük a metabolikus szindróma, ami egy multifaktoriális eredetű, komplex anyagcserezavar. A metabolikus szindróma magába foglalja a hasi elhízást,
Ferenci, Bettina
core  

Diosgenin inhibits cell proliferation of primary human thyrocytes via downregulation of PI3K/Akt signaling pathway

, 2018
Purpose: To determine the potential influence of diosgenin on proliferation of human thyrocytes and its possible mechanism.Methods: Primary human thyrocytes were cultured and treated with diosgenin at various time intervals.
Lu, Yuxian, Bian, Dezhi, Xu, Ke, Qian, Xiaojuan, Wen, Fen, Liu, Yanmei   +5 more
core   +1 more source

Predicting the potential global distribution of diosgenin-contained Dioscorea species

Chinese Medicine, 2018
Background Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological damage, wild Dioscorea species
Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li, Shilin Chen   +6 more
doaj   +1 more source

Microbial metabolism of diosgenin by a novel isolated Mycolicibacterium sp. HK‐90: A promising biosynthetic platform to produce 19‐carbon and 21‐carbon steroids

Microbial Biotechnology
Green manufacture of steroid precursors from diosgenin by microbial replacing multistep chemical synthesis has been elusive. It is currently limited by the lack of strain and degradation mechanisms.
Zhikuan Wang, Hailiang Qiu, Yulong Chen, Xuemin Chen, Chunhua Fu, Longjiang Yu   +5 more
doaj   +1 more source

Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase.

PLoS ONE, 2014
Diabetes mellitus is a multifactorial metabolic disease characterized by post-prandial hyperglycemia (PPHG). α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic agents.
Sougata Ghosh, Piyush More, Abhishek Derle, Ajay B Patil, Pramod Markad, Adersh Asok, Navanath Kumbhar, Mahemud L Shaikh, Boppana Ramanamurthy, Vaishali S Shinde, Dilip D Dhavale, Balu A Chopade   +11 more
doaj   +1 more source

Meme kanseri hücre soylarında diosgenin ve daktolisibin kooperatif etkisinin belirlenmesi

, 2019
Amaç: Bu çalışmada MCF-7 meme kanseri hücre soylarında diosgeninin maddesinin anti-kanserojen etkisinin, PI3K/ Akt ve mTOR inhibitörü olan daktolisib ile nasıl değiştiğini belirlenmesi amaçlandı. Çalışmamızda, meme kanseri MCF-7 hücre hattında
Karadeniz, Melike
core