Results 91 to 100 of about 2,018 (130)

Dioscorea Belizensis Lundell as A Source of Diosgenin

, 1963
Twenty-nine species of wild Dioscorea from British Honduras were screened for saponins. The tubers of D. belizensis Lundell afforded yields of steroids of about 2 per cent of the dry weight, calculated as the acetate of the predominant genin, diosgenin ...
G Blunden, R Hardman
core   +1 more source

Epoxidation of Diosgenin, 25(R)-1,4,6-Spirostatrien-3-one and 25(R)-4,6-Spirostadien-3β-ol

, 2003
Upon treatment of 25(R)-spirost-5-en-3β-ol (diosgenin), 25(R)-1,4,6-spirostatrien-3-one and 25(R)-4,6-spirostadien-3β-ol with 30% H2O2 and 5% NaOH in methanol, diosgenin did not react, 25(R)-1,4,6-spirostatrien-3-one was converted to 25(R)-1Π...
Jongwon Kim, Eunsook Ma
core   +1 more source

Microbial metabolism of diosgenin by a novel isolated Mycolicibacterium sp. HK‐90: A promising biosynthetic platform to produce 19‐carbon and 21‐carbon steroids

Microbial Biotechnology
Green manufacture of steroid precursors from diosgenin by microbial replacing multistep chemical synthesis has been elusive. It is currently limited by the lack of strain and degradation mechanisms.
Zhikuan Wang, Hailiang Qiu, Yulong Chen, Xuemin Chen, Chunhua Fu, Longjiang Yu   +5 more
doaj   +1 more source

Role of diosgenin extracted from Helicteres isora L in suppression of HIV-1 replication: An in vitro preclinical study

Heliyon
Background: Diosgenin, an essential sapogenin steroid with significant biological implications, is composed of a hydrophilic sugar moiety intricately linked to a hydrophobic steroid aglycone.
Smita Rakshit, Ashwini More, Shraddha Gaikwad, Chandrabhan Seniya, Aniket Gade, Vijaykumar Yogesh Muley, Anupam Mukherjee, Kapil Kamble   +7 more
doaj   +1 more source

Diosgenin Attenuates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats: Underlying Mechanisms

, 2021
Objective: Prolonged diabetes mellitus causes impairments of cognition and attentional dysfunctions. Diosgenin belongs to a group of steroidal saponins with reported anti-diabetic and numerous protective properties.
Baluchnejadmojarad, T., Mahmoudi, N., Sanaierad, A., Kiasalari, Z., Rahmani, T., Afshin-Majd, S., Naderi, G., Roghani, M.   +7 more
core  

Diosgenin via NMDA Receptor Exerted Anxiolytic-like Effect in Maternally Separated Mice

, 2020
Background and aim: Anxiety is one of the most common psychiatric disorders that lead to disruption of daily and quality of life. Routine medications have many side effects and cause physical dependence and psychosocial addiction.
Boroujeni, Shakiba Nasiri, Amini-Khoei, Hossein, Boldaji, Fatemeh Rahimi, Lorigooini, Zahra   +3 more
core   +1 more source

The antioxidant activity of diosgenin, a plant steroid sapogenin, in C2C12 myoblasts is achieved by blocking mitochondrial ROS production

Applied Biological Chemistry
Diosgenin, a plant-derived steroid sapogenin, has been reported to have many health benefits, including antioxidant activity. Although oxidative stress is a major factor impeding the differentiation and homeostasis of skeletal muscles, its antioxidant ...
Cheol Park, Gi-Young Kim, Yung Hyun Choi
doaj   +1 more source

Diosgenin reverses posttraumatic stress disorder in mice by augmenting neurochemical release and inhibiting HPA axis dysfunction, oxidative stress, and neuroinflammation

Journal of Affective Disorders Reports
Post-traumatic stress disorder (PTSD) is a mental disorder linked to neurochemical, hypothalamic-pituitary-adrenal (HPA)-axis dysregulations, inflammatory and pro-oxidant challenges in response to traumatic events.
Benneth Ben-Azu, Olusegun G. Adebayo, Adaeze Adebesin, Kenneth C. Oparaji, Vivian O. Ojiakor, Gift C. Pender, Bensandy O. Odeghe, Noah A. Omeiza, Halimat A. Abdulrahim, Vivian Ezieshi, Glory Ighosotu, Emmanuel Omo-Odudu, Ekene I. Monye   +12 more
doaj   +1 more source

Production of diosgenin by hairy root cultures of Trigonella foenum-graecum L

, 1997
Hairy root cultures of Trigonella foenum-graecum L. were established with Agrobacterium rhizogenes strain A4. The hairy roots produce diosgenin, an important spirostanol for the semi-synthesis of steroid hormones.
Christen, Philippe, Kapetanidis, Ilias, Merkli, Alain, Merkli A, Christen P, Kapetanidis I   +5 more
core   +1 more source

Estimation of free binding energies of Tigogenin, Diosgenin and Alogliptin.

Estimation of free binding energies of Tigogenin, Diosgenin and Alogliptin.
Sheikh Sunzid Ahmed (14802879), M. Oliur Rahman (16940167)   +1 more
core   +1 more source