Results 111 to 120 of about 5,720 (220)

Diosgenin reverses posttraumatic stress disorder in mice by augmenting neurochemical release and inhibiting HPA axis dysfunction, oxidative stress, and neuroinflammation

Journal of Affective Disorders Reports
Post-traumatic stress disorder (PTSD) is a mental disorder linked to neurochemical, hypothalamic-pituitary-adrenal (HPA)-axis dysregulations, inflammatory and pro-oxidant challenges in response to traumatic events.
Benneth Ben-Azu, Olusegun G. Adebayo, Adaeze Adebesin, Kenneth C. Oparaji, Vivian O. Ojiakor, Gift C. Pender, Bensandy O. Odeghe, Noah A. Omeiza, Halimat A. Abdulrahim, Vivian Ezieshi, Glory Ighosotu, Emmanuel Omo-Odudu, Ekene I. Monye   +12 more
doaj   +1 more source

Diosgenin: Ethnopharmacology, Mechanism of Actions, and Formulations

Diosgenin, a unique steroidal saponin, offers a variety of pharmacological benefits due to its distinctive chemical structure. To fully harness its therapeutic potential, it is crucial to thoroughly understand its chemical and physical properties ...
Priyanka Singh Chaudhary
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Containment of neuroimmune challenge by diosgenin confers amelioration of neurochemical and neurotrophic dysfunctions in ketamine-induced schizophrenia in mice

Brain Disorders
Inhibition of neuroinflammation through N-methyl-D-aspartate receptor (NMDAR) regulation can provide normalization of neurochemical homeostasis and neurotrophic support in the pathogenesis of psychiatric disorders with complex symptoms such as ...
Benneth Ben-Azu, Olusegun G. Adebayo, Aliance R. Fokoua, Jackson E. Onuelu, Jerome N. Asiwe, Emuesiri G. Moke, Itivere A. Omogbiya, Oghenemarho L. Okpara, Jennifer E. Okoro, Omadevuaye M. Oghenevwerutevwe, Christian I. Uruaka   +10 more
doaj   +1 more source

Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression.

, 2004
International audienceIn the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with ...
Liagre, Bertrand, Vergne-Salle, Pascale, Bertrand Liagre, Cecile Corbiere, Corbière, Cécile, Jean L Beneytout, Pascale Vergne-Salle, Jean L Charissoux, Charissoux, Jean, Beneytout, Jean   +9 more
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Molecular characterization of diosgenin biosynthesis in different organs of Trigonella foenum-graecum L.

Fenugreek, an annual herb, is a significant source of diosgenin, a triterpene with bioactive properties. This study aimed to molecularly characterize diosgenin biosynthesis in various organs of fenugreek, including flowers, immature leaves, developing ...
Kim, Jae Kwang, Kwon, Do Yeon, Uddin, Md. Romij, Park, Sang Un, Sathasivam, Ramaraj, Lim, Jinsu   +5 more
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Diosgenin via NMDA Receptor Exerted Anxiolytic-like Effect on Maternally Separated Mice

, 2021
Background and aim: Anxiety is one of the most common psychiatric disorders that lead to the disruption of daily life and also the quality of life.
Boroujeni, Shakiba Nasiri, Amini-Khoei, Hossein, Boldaji, Fatemeh Rahimi, Lorigooini, Zahra   +3 more
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Protective effect of diosgenin on LPS/D-Gal-induced acute liver failure in C57BL/6 mice

, 2020
Acute liver failure (ALF) is a deadly clinical syndrome, which leads to a rapid loss of normal liver function. Diosgenin is a natural steroidal sapogenin found in various plant families.
Khanizadeh, A.M., Baluchnejadmojarad, T., Mohamadi-Zarch, S.-M., Roghani, M., Nourabadi, D.   +4 more
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Diosgenin: A Potential Therapeutic Phytocompound for the Management of Atherosclerosis and Other Physiological Disorders

Natural Product Communications
The present study is aimed to explore the therapeutic attributes of diosgenin against atherosclerosis and associated health disorder. Side effects associated with synthetic drugs for the treatment and management of diseases worldwide have necessitated ...
Rizwan ur-Rehman, Sania Riaz, Misha Arooj, Saleha Khan, Urwa Tariq, Maliha Fatima   +5 more
doaj   +1 more source

Exploring the anti-angiogenic properties of diosgenin saponin from Trigonella graecum (fenugreek): A study on Zebrafish embryos

National Journal of Physiology, Pharmacy and Pharmacology
Background: Angiogenesis plays a role in both physiological and pathological processes such as wound healing, embryonic development, and cancer metastasis, and it is the process by which new blood vessels are formed from existing ones.
Dapkupar Wankhar, Sambhavi Bhagavatheeswaran, Vinu Ramchandran, Sambantham Shanmugam, Anandan Balakrishnan   +4 more
doaj   +1 more source

Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-Galactose

, 2011
[[abstract]]This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the
Chiu, CS;Chiu, YJ;Wu, LY;Lu, TC;Huang, TH;Hsieh, MT;Lu, CY;Peng, WH
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