Results 81 to 90 of about 6,183 (145)

Immunomodulatory, Antifatigue, and Hypoxia Tolerance Effects of Polygonatum cirrhifolium Polysaccharides: Structural Characterization and MAPK/NF‐κB Pathway Insights

Starch - Stärke, Volume 78, Issue 11, November 2026.
This study provides evidence that Polygonatum cirrhifolium polysaccharides possesses significant immunomodulatory, antifatigue, and hypoxia‐tolerance effects. The findings suggest that the MAPK/NF‐κB signaling pathway may be involved in its immunoregulatory actions and that PCP could be a promising candidate for enhancing physical performance and ...
Jun Nan, Yuanyuan Chen, Pei Qun, Bengui Ye, Dawa Zhuoma   +4 more
wiley   +1 more source

UHPLC-Q-TOF/MS unveils metabolic diversity in Paris L. and highlights medicinal potential of five newly identified species

Frontiers in Pharmacology
Paris species are widely distributed across China, with their rhizomes traditionally used in Chinese medicine. P. polyphylla var. chinensis (PPC) and P. polyphylla var.
Kangmeng Sun, Yingying Shao, Rong Li, Zhi Wang, Jinghan Wang, Xinyu Luan, Changqiao Wu, Liya Wang, Chunnian He, Qi Tang   +9 more
doaj   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Functional characterization of a novel β-glucosidase converting trillin to diosgenin from Enterococcus faecalis

Microbial Cell Factories
Background Diosgenin, known as “medicinal gold”, is the main precursor for the synthesis of steroid hormone drugs. Currently, diosgenin is primarily produced industrially via the extraction of plant-derived steroidal saponins followed by acid hydrolysis,
Chen Zhou, Mengying Zhu, Qi Li, Wenjun Deng, Ningning Sun, Wenting Liu, Yawen Li, Xinyue Wang, Fan Zhang, Li Li, Jing Li   +10 more
doaj   +1 more source

Steroidal Saponins from Water Eggplant (Fruits of Solanum torvum) Exhibit Anti-Epileptic Activity against Pentylenetetrazole-Induced Seizure Model in Zebrafish

Molecules
The fruits of Solanum torvum Swartz, a wild relative of eggplant, are consumed as a wild vegetable in tropical regions of Africa, Asia, and South America. In traditional Chinese medicine, it is believed to have anti-inflammatory and sedative effects.
Rui Ren, Ming-yan Zhang, Tengyun Shu, Ya-ting Kong, Li-hua Su, Hai-zhou Li   +5 more
doaj   +1 more source

Potent Anticancer Effect of the Natural Steroidal Saponin Gracillin Is Produced by Inhibiting Glycolysis and Oxidative Phosphorylation-Mediated Bioenergetics. [PDF]

Cancers (Basel), 2020
Min HY, Pei H, Hyun SY, Boo HJ, Jang HJ, Cho J, Kim JH, Son J, Lee HY.   +8 more
europepmc   +1 more source

Botrytis cinerea combines four molecular strategies to tolerate membrane-permeating plant compounds and to increase virulence

Nature Communications
Saponins are plant secondary metabolites comprising glycosylated triterpenoids, steroids or steroidal alkaloids with a broad spectrum of toxicity to microbial pathogens and pest organisms that contribute to basal plant defense to biotic attack. Secretion
Yaohua You, H. M. Suraj, Linda Matz, A. Lorena Herrera Valderrama, Paul Ruigrok, Xiaoqian Shi-Kunne, Frank P. J. Pieterse, Anne Oostlander, Henriek G. Beenen, Edgar A. Chavarro-Carrero, Si Qin, Francel W. A. Verstappen, Iris F. Kappers, André Fleißner, Jan A. L. van Kan   +14 more
doaj   +1 more source

Anti- Cancer Potential of Diosgenin, a Steroidal Saponin, against Human Oral Cancer Cells. [PDF]

Asian Pac J Cancer Prev
Dutta U, Dey S, Boruah M, Sailo BL, Muchahary B, Kunnumakkara AB.   +5 more
europepmc   +1 more source

Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study. [PDF]

Drug Des Devel Ther
Lu D, Huang L, Weng C.
europepmc   +1 more source

An In Vitro Study on the Cytotoxic, Antioxidant, and Antimicrobial Properties of Yamogenin-A Plant Steroidal Saponin and Evaluation of Its Mechanism of Action in Gastric Cancer Cells. [PDF]

Int J Mol Sci
Stefanowicz-Hajduk J, Graczyk P, Hering A, Gucwa M, Nowak A, Hałasa R.   +5 more
europepmc   +1 more source