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Journal of Medicinal Chemistry, 1992
Complementarity of electrostatic potential surface maps was utilized in defining bioisosteric steroidal androgen receptor antagonists. Semiempirical and ab initio level calculations performed on a series of methanesulfonyl heterocycles indicated the requirement for a partial negative charge at the heteroatom attached to C-3 of the steroid nucleus to ...
J P, Mallamo +9 more
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Complementarity of electrostatic potential surface maps was utilized in defining bioisosteric steroidal androgen receptor antagonists. Semiempirical and ab initio level calculations performed on a series of methanesulfonyl heterocycles indicated the requirement for a partial negative charge at the heteroatom attached to C-3 of the steroid nucleus to ...
J P, Mallamo +9 more
openaire +2 more sources
Steroids XXIII. Synthesis of Some Ring A-Fused Heterocyclic Steroids
Journal of Pharmaceutical Sciences, 1965Several ring A-fused heterocyclic steroids, which were prepared as potential anabolic agents, are described. These include steroids with triazole, tetrahydropyrazine, and benzothiazine rings fused onto positions 2,3 of a derivative of methyltestosterone.
Norman J. Doorenbos, Conrad P. Dorn
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