Results 201 to 210 of about 16,062 (239)
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The Journal of Steroid Biochemistry and Molecular Biology, 2014
7-Dehydrocholesterol (7-DHC) is a common precursor of vitamin D3 and cholesterol. Although various oxysterols, oxygenated cholesterol derivatives, have been implicated in cellular signaling pathways, 7-DHC metabolism and potential functions of its metabolites remain poorly understood.
Kaori, Endo-Umeda +8 more
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7-Dehydrocholesterol (7-DHC) is a common precursor of vitamin D3 and cholesterol. Although various oxysterols, oxygenated cholesterol derivatives, have been implicated in cellular signaling pathways, 7-DHC metabolism and potential functions of its metabolites remain poorly understood.
Kaori, Endo-Umeda +8 more
openaire +2 more sources
Functional analysis of the promoter of human sterol 27-hydroxylase gene in HepG2 cells
Gene, 2002Human sterol 27-hydroxylase catalyses the first step in the alternative pathway of bile acids biosynthesis in hepatocytes. However the gene encoding this enzyme (CYP27 gene) is expressed in every tissue and some evidence suggests that this enzyme plays a role in cholesterol homeostasis.
GARUTI R +5 more
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
7-Ketocholesterol (7KC) is a major oxysterol found in atherosclerotic plaque and is believed to be derived both endogenously and exogenously (from the diet). Previously, we have demonstrated that subsequent to hepatic lipoprotein uptake, 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the ...
Malcolm A, Lyons +2 more
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7-Ketocholesterol (7KC) is a major oxysterol found in atherosclerotic plaque and is believed to be derived both endogenously and exogenously (from the diet). Previously, we have demonstrated that subsequent to hepatic lipoprotein uptake, 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the ...
Malcolm A, Lyons +2 more
openaire +2 more sources
Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling
Neuroscience, 2009Cholesterol is required in the brain for synaptogenesis and its turnover is critical for cerebral functions. Several proteins involved in cholesterol handling and metabolism are transcriptionally regulated by the nuclear liver X receptor (LXR) alpha and beta.
F. Gilardi +9 more
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Human Genetics, 1995
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid-storage disease caused by mutations in the sterol 27-hydroxylase gene (CYP27). So far several mutations causing CTX have been identified and characterized. A new mutation creating an insertion of cytosine at position 6 in the cDNA, which is expected to result in a frameshift and a ...
H, Segev +5 more
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Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid-storage disease caused by mutations in the sterol 27-hydroxylase gene (CYP27). So far several mutations causing CTX have been identified and characterized. A new mutation creating an insertion of cytosine at position 6 in the cDNA, which is expected to result in a frameshift and a ...
H, Segev +5 more
openaire +2 more sources
Human Molecular Genetics, 1994
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid-storage disease caused by mutations in the sterol 27-hydroxylase gene (CYP27). So far several mutations causing CTX have been identified and characterized. A new mutation creating an insertion of cytosine at position 6 in the cDNA, which is expected to result in a frameshift and a ...
V, Meiner +4 more
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Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid-storage disease caused by mutations in the sterol 27-hydroxylase gene (CYP27). So far several mutations causing CTX have been identified and characterized. A new mutation creating an insertion of cytosine at position 6 in the cDNA, which is expected to result in a frameshift and a ...
V, Meiner +4 more
openaire +2 more sources
Proceedings of the Association of American Physicians, 1998
We investigated the effect of sitosterol on hepatic sterol 27-hydroxylase activities in subjects with sitosterolemia, a recessive inherited disease associated with accelerated atherosclerosis and increased levels of sitosterol and other plant sterols and stanols in tissues.
L B, Nguyen +4 more
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We investigated the effect of sitosterol on hepatic sterol 27-hydroxylase activities in subjects with sitosterolemia, a recessive inherited disease associated with accelerated atherosclerosis and increased levels of sitosterol and other plant sterols and stanols in tissues.
L B, Nguyen +4 more
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Down-regulation of the rat hepatic sterol 27-hydroxylase
The Journal of Steroid Biochemistry and Molecular Biology, 1999Yi-Ping Rao +6 more
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Transcriptional regulation of human sterol 27-hydroxylase gene in HepG2 cells
Atherosclerosis Supplements, 2001R. Garuti +3 more
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Liver sterol 27 hydroxylase in hamster: Modulation by steroids and diets
Atherosclerosis, 2000C. Lutton +3 more
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