Results 171 to 180 of about 19,805 (217)

Measurement of human sterol-o-acyltransferase 1, soat1 levels in Iraqi diabetic patients

International Journal of Chemical and Biological Sciences
Hussein Najm Abed
semanticscholar   +3 more sources

Impact of the sterol O-acyltransferase gene (Cmare2) on morphology and stability of the mushroom Cordyceps militaris

International Journal of Biological Macromolecules
Strain degeneration in mushroom cultivation can lead to significant commercial losses, yet the genetic factors remain elusive. This study identified the sterol O-acyltransferase gene, Cmare2, which is associated with colony sectorization in Cordyceps militaris, using a T-DNA insertion-mutant library.
Mengqian Liu, Mengfei Zhang, Meiyu Huai, Fangxu Xu, Guoliang Meng, Fen Wang, Caihong Dong   +6 more
semanticscholar   +4 more sources

Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142

The Journal of Antibiotics, 2018
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the fungus Aspergillus nidulans BF-0142 along with a known helvafuranone (3). The structures of 1 and 2 were elucidated based on spectroscopic analyses by the interpretation of one-dimensional and two-dimensional nuclear magnetic ...
Takashi Fukuda, Takun Furukawa, Keisuke Kobayashi, Kenichiro Nagai, Ryuji Uchida, Hiroshi Tomoda   +5 more
semanticscholar   +4 more sources

Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet

Biochemical and Biophysical Research Communications, 2018
Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice with a C57BL6 background fed a HFD were used to explore the role of SOAT1 in the hypothalamus.
Ning Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Dong-Huan Zhang, Honglei Wang   +6 more
semanticscholar   +5 more sources

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Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440

The Journal of Antibiotics, 2020
New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1-3 have a common indoline-diterpene core and two additional isoprenyl moieties.
Taichi Ohshiro, H. Morita, Elyza Aiman Azizah Nur, Kanji Hosoda, R. Uchida, H. Tomoda   +5 more
semanticscholar   +5 more sources

Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential.

Journal of Medicinal Chemistry, 2022
Sterol O-acyltransferase (SOAT) is a membrane-bound enzyme that aids the esterification of cholesterol and fatty acids to cholesterol esters. SOAT has been studied extensively as a potential drug target, since its inhibition can serve as an alternative ...
Pinaki Bhattacharjee, Nicholas Rutland, Malliga R. Iyer   +2 more
semanticscholar   +1 more source

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209 [PDF]

The Journal of Antibiotics, 2016
The enzyme sterol O-acyltransferase (SOAT, also known as acyl-CoA:cholesterol acyltransferase (ACAT)), an endoplasmic reticulum membrane protein, has important roles in cholesterol regulation in humans.1 SOAT is expected to be a promising target for the development of new anti-atherosclerotic agents.
A. Suzuki, T. Fukuda, Keisuke Kobayashi, Taichi Ohshiro, H. Tomoda   +4 more
semanticscholar   +3 more sources

Diacylglycerol-sterol O-acyltransferase

, 1996
Dietmar Schomburg, Dörte Stephan
openalex   +2 more sources

A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma

Investigational New Drugs, 2020
Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with very limited treatment options. Nevanimibe HCl (formerly ATR-101), a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, has been shown in nonclinical studies to decrease adrenal steroidogenesis at lower doses and to cause apoptosis of adrenocortical ...
David C. Smith, M. Kroiss, E. Kebebew, M. Habra, R. Chugh, Bryan J. Schneider, M. Fassnacht, Pegah Jafarinasabian, M. Ijzerman, Vivian H. Lin, P. Mohideen, A. Naing   +11 more
semanticscholar   +4 more sources

Sterol O-acyltransferase

, 2006
Antje Chang, Ida Schomburg, Professor Dietmar Schomburg   +2 more
openalex   +2 more sources