Results 11 to 20 of about 61,990 (306)

Molecular Dynamics-Guided Sterol Engineering of mRNA-Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen-Selective Immunity. [PDF]

Adv Sci (Weinh)
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Jeon S, Bae SH, Ji J, Lee J, Choi H, Kang MH, Park SI, Kim H, Lee N, Lee H, Kim S, Kim J, Yoon S, Lee S, Cho S, Ha D, Oh A, Jo S, Choi H, Lee Y, Lee S, Park HJ, Nam G, Shin J, Kang Y, Im W, Lee K, Nam JH.   +27 more
europepmc   +2 more sources

Fat from Tenebrionidae bugs – Sterols content, fatty acid profiles, and cardiovascular risk indexes [PDF]

, 2019
This work focused on analysing the content of selected sterols and profile of fatty acids of edible insect species – mealworm (Tenebrio molitor) and superworm (Zophobas morio), which are expected to increase their usability in human nutrition.
Mlček, Jiří, Knížková, Ivana, Bednářová, Martina, Adámek, Martin, Adámková, Anna, Borkovcová, Marie   +5 more
core   +3 more sources

Sterol concentration and distribution in sunflower seeds (Helianthus annuus L.) during seed development [PDF]

, 2010
Sunflower seeds are currently used for edible oil production. Among oil minor compounds, phytosterols are of special interest due to their cholesterol reducing properties.
Merah, O, Mouloungui, Zephirin,, Alignan, Marion,, Alignan, Marion, M., Cerny, Muriel, M., Mouloungui, Zéphirin, Cerny, Muriel,, Merah, Othmane, Mouloungui, Zephirin, Z., Cerny, Muriel, Bouniols, Andrée, Alignan, Marion, Roche, Jane   +12 more
core   +1 more source

Sterol content in sunflower seeds (Helianthus annuus L.) as affected by genotypes and environmental conditions [PDF]

, 2010
Phytosterols play essential roles in many plant cell mechanisms. They are of industrial interest since, as part of the diet, they can reduce Low Density Lipoprotein cholesterol.
Roche, Jane, J., Merah, Othmane,, Merah, Othmane, O., Vear, Felicity,, Mouloungui, Zephirin,, Alignan, Marion,, Alignan, Marion, M., Cerny, Muriel, M., Bouniols, Andrée,, Vear, Felicity, Mouloungui, Zéphirin, Cerny, Muriel,, Merah, Othmane, Roche, Jane,, Mouloungui, Zephirin, Z., Cerny, Muriel, Bouniols, Andrée, A., Bouniols, Andrée, Vear, Felicity, F., Alignan, Marion, Roche, Jane   +20 more
core   +1 more source

Effects of genotype and sowing date on phytostanol-phytosterol content and agronomic traits in wheat under organic agriculture [PDF]

, 2009
Cereals are an important source of sterols and stanols in the human diet. The present study underlines the effect of genotype and weather conditions in bread wheat, on total sterol and stanol content (TSS), agronomic traits, proteins and ash content ...
Merah, Othmane,, Cerny, Muriel, Bouniols, Andrée, Mouloungui, Zephirin,, Alignan, Marion,, Alignan, Marion, Mouloungui, Zéphirin, Cerny, Muriel,, Merah, Othmane, Roche, Jane   +9 more
core   +1 more source

Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8

Journal of Lipid Research, 2002
The plasma concentrations of cholesterol precursor sterols and plant sterols vary over a 5- to 10-fold range among normolipidemic individuals, and provide indices of the relative rates of cholesterol synthesis and fractional absorption.
Knut E. Berge, Klaus von Bergmann, Dieter Lutjohann, Rudy Guerra, Scott M. Grundy, Helen H. Hobbs, Jonathan C. Cohen   +6 more
doaj   +1 more source

Microwave-Assisted Saponification Method Followed by Solid-Phase Extraction for the Characterization of Sterols and Dialkyl Ketones in Fats

Foods, 2021
Unlike other fields, the methods routinely applied for fats and oils are still tied to traditional, time- and solvent-consuming procedures, such as saponification, column chromatography and thin-layer chromatography.
Steven Mascrez, Sabine Danthine, Giorgia Purcaro   +2 more
doaj   +1 more source

Esterification of injected epicoprostanol in a human subject

Journal of Lipid Research, 1969
That a necessary requirement for in vivo esterification of 3-hydroxy sterols is the equatorial conformation of the hydroxyl group has been substantiated by the administration of epicoprostanol-3β-3H (3-OH equatorial) to a man with a complete biliary ...
R.S. Rosenfeld, Leon Hellman
doaj   +1 more source

Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

Journal of Lipid Research, 2022
Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function.
Ferdinand Fandrei, Oskar Engberg, Lukáš Opálka, Pavla Jančálková, Petra Pullmannová, Miloš Steinhart, Andrej Kováčik, Kateřina Vávrová, Daniel Huster   +8 more
doaj   +1 more source

The effects of sterol structure upon sterol esterification [PDF]

Atherosclerosis, 2010
Cholesterol is esterified in mammals by two enzymes: LCAT (lecithin cholesterol acyltransferase) in plasma and ACAT(1) and ACAT(2) (acyl-CoA cholesterol acyltransferases) in the tissues. We hypothesized that the sterol structure may have significant effects on the outcome of esterification by these enzymes.
Don S, Lin, Robert D, Steiner, Louise S, Merkens, Anuradha S, Pappu, William E, Connor   +4 more
openaire   +2 more sources