Results 131 to 140 of about 7,281 (146)

Matching the Diversity of Sulfated Biomolecules: Creation of a Classification Database for Sulfatases Reflecting Their Substrate Specificity. [PDF]

PLoS One, 2016
Barbeyron T, Brillet-Guéguen L, Carré W, Carrière C, Caron C, Czjzek M, Hoebeke M, Michel G.   +7 more
europepmc   +1 more source

Characterizing the distribution of steroid sulfatase during embryonic development: when and where might metabolites of maternal steroids be reactivated?

J Exp Biol, 2017
Paitz RT, Duffield KR, Bowden RM.
europepmc   +1 more source

Human Placental Steryl-Sulfatase. Enzyme Purification, Production of Antisera, and Immunoblotting Reactions with Normal and Sulfatase-Deficient Placentas

Biological Chemistry Hoppe-Seyler, 1986
The steryl-sulfatase of normal human placental microsomes was solubilized and enriched about 350-fold. Chromatography on Sepharose 6B of the purified enzyme preparation revealed a single protein peak which eluted according to an apparent molecular mass of 270 +/- 30 kDa; when electrophorized on sodium dodecyl sulfate polyacrylamide gel the sulfatase ...
L, Dibbelt, E, Kuss
semanticscholar   +4 more sources

Inhibition of steryl sulfatase activity in LNCaP human prostate cancer cells

Steroids, 2002
The enzyme steryl sulfatase may help support the growth of hormone-dependent tumors, including prostate cancers, by facilitating the conversion of circulating precursor steroids to active hormones. We sought to determine the presence of steryl sulfatase activity in the androgen-dependent human prostate cancer cell line LNCaP, and to determine if this ...
Kyle W, Selcer, Heidi, Kabler, Jennifer, Sarap, Zili, Xiao, Pui-Kai, Li   +4 more
semanticscholar   +4 more sources

Steryl-sulfatase

, 1991
Dietmar Schomburg, Margit Salzmann
openaire   +2 more sources

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Glucosinolate Sulfatases-Sulfatase-Modifying Factors System Enables a Crucifer-Specialized Moth To Pre-detoxify Defensive Glucosinolate of the Host Plant.

Journal of Agricultural and Food Chemistry, 2022
Numerous herbivores orally secrete defense compounds to detoxify plant toxins. However, little is known about the role of orally secreted enzymes by a specialized pest, Plutella xylostella, in the detoxification of plant defense compounds.
Wei Chen, H. S. A. Saqib, Xuejiao Xu, Yuhong Dong, Ling Zheng, Ying-Jang Lai, Xiaodong Jing, Zhanjun Lu, Linyang Sun, M. You, Weiyi He   +10 more
semanticscholar   +1 more source

Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer.

Cancer Research
Tumor stroma plays a critical role in fostering tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma. Identifying the key molecular determinants for the pro-tumor properties of CAFs could enable
Huijuan Wang, Jiaxin Chen, Xiaoyu Chen, Yingqiang Liu, Jiawei Wang, Qing Meng, Huogang Wang, Ying He, Yujia Song, Jingyun Li, Zhenyu Ju, Peng Xiao, Junbin Qian, Zhangfa Song   +13 more
semanticscholar   +1 more source

Inhibition of endogenous miR‐23a/miR‐377 in CHO cells enhances difficult‐to‐express recombinant lysosomal sulfatase activity

Biotechnology progress (Print), 2020
Difficult‐to‐express (DTE) recombinant proteins such as multi‐specific proteins, DTE monoclonal antibodies, and lysosomal enzymes have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells or other mammalian cells as production ...
Ifeanyi Michael Amadi, V. Agrawal, Terri M. Christianson, Cameron L. Bardliving, P. Shamlou, J. Lebowitz   +5 more
semanticscholar   +1 more source

A Trisaccharide Sulfate and its Sulfonamide as Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1.

Journal of the American Chemical Society, 2020
Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated with ...
L. Chiu, Narayana Murthy Sabbavarapu, Wei‐Chen Lin, Chiao-Yuan Fan, Chih-Chung Wu, T. Cheng, Chi‐Huey Wong, S. Hung   +7 more
semanticscholar   +1 more source

Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase.

Journal of Medicinal Chemistry, 2000
R. Boivin, V. Luu-The, R. Lachance, F. Labrie, D. Poirier   +4 more
semanticscholar   +1 more source