We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma +22 more
wiley +1 more source
From silos to synergies: harnessing the power of sexual health data sources in England to understand changing epidemiology and inform policy. [PDF]
Ogaz D +11 more
europepmc +1 more source
Causal‐Guided Ultra‐Long‐Term Time Series Forecasting Via Anticipated Covariates
Often treated as unknown, information from the future remains underutilized.We demonstrate that in a coupled dynamical system, providing the future state of the effect enables accurate forecasting of the cause for a long timesteps. A time series forecasting paradigm that introduces anticipated covariates to represent such known future states is ...
Jintong Zhao +4 more
wiley +1 more source
Identification of risk profiles among persons attending a sexually transmitted infection clinic in Estonia. [PDF]
Toompere K +6 more
europepmc +1 more source
Ferroelectric HZO thin films enable negative differential resistance in calibrated FeCNTFET models, creating stable ternary switching states for compact multi‐valued logic. The resulting device‐to‐architecture framework demonstrates efficient ternary neural‐network accelerators with substantial area and power savings, highlighting ferroelectric CNT ...
Mohammad Khaleqi Qaleh Jooq +9 more
wiley +1 more source
Trends in prevalence of <i>Trichomonas vaginalis</i> among patients of an STI clinic in the Netherlands: a 9-year retrospective study. [PDF]
Kampman CJG +4 more
europepmc +1 more source
New Adventures in Surveillance, Electronic Health Record –Sexually Transmitted Diseases (EHR-STI)
Surveillance is information for action Timely high quality electronic surveillance data is essential to inform ▪ Health service planning ▪ National public health policy ▪ Public awareness ▪ European and Global Public Health Policy – TESSy reporting/WHO ...
Neary, Martha
core
Abstract Ethiopian durum wheat (Triticum turgidum ssp. durum) is a globally significant crop recognized for its rich genetic diversity, stress adaptation, and high grain quality. This review consolidates over 20 years of research on the phenotypic and genotypic characterization of Ethiopian durum wheat landraces, focusing on trait discovery, genome ...
Agegnehu Mekonnen Tessema +3 more
wiley +1 more source
Integrated Diagnosis of Hepatitis B, C, and D Viruses and HIV in Populations Evaluated for Sexually Transmitted Infections: A Narrative Review and Operational Framework. [PDF]
Cabezas J +12 more
europepmc +1 more source
ABSTRACT Amid increasing environmental and economic pressures, Africa's transition to a circular economy (CE) presents a vital pathway to inclusive, low‐carbon development. Yet, how digital transformation, informal innovation, and science, technology, and innovation (STI) policy readiness shape CE outcomes remains underexplored.
Emmanuel K. Manu +2 more
wiley +1 more source

