Results 31 to 40 of about 241,502 (294)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Thermodynamics and kinetics of boundary friction [PDF]
, 2011 A deterministic theory describing the behavior of an ultrathin lubricant film between two atomically-smooth solid surfaces is proposed. For the description of lubricant state the parameter of excess volume arising due to chaotization of solid medium ...
Metlov, L.S. +6 more
core
Observation and modeling of the suction pump effect during rapid dilatant slip [PDF]
, 2003 The temporary pressure drop observed during post-peak dilatant slip in axi-symmetric testing of a porous aeolian sandstone is modeled using a simple function of opening caused by sliding along the fault surface.
Rudnicki, J. W. +3 more
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Stick-slip singularity of the Giesekus fluid [PDF]
, 2015 The local asymptotic behaviour at the stick-slip singularity is determined for the Giesekus fluid in the presence of a solvent viscosity. In planar steady flow, the method of matched asymptotic expansions is used to show that it comprises a three region ...
Evans, Jonathan
core +1 more source
Dataset on critical angular clamping speeds of fasteners
Data in BriefThis article reports on an experiment that studied the critical angular clamping speeds for fasteners using the Design of Experiments (DOE) methodology and Analysis of Variance (ANOVA). The study aimed to investigate the stick-slip phenomenon, a critical
Jeferson Ferreira +5 more
doaj +1 more source
Numerical Study on Characteristics of Stick-Slip Instability of Coal-Rock Parting-Coal Structure under Lateral Unloading [PDF]
LithosphereUnloading excavation can increase the possibility of rock burst, especially for coal seam with rock parting. In order to explore the evolution process of rock burst under lateral unloading, the combination of in situ measures and numerical experiments is
Heng Zhang +5 more
doaj +1 more source
Stick‐Slip Tremor Beneath an Alpine Glacier
Geophysical Research Letters, 2021 Sliding of glacial ice over its base is typically described by a frictionless or slowly deforming bed. This view is challenged by recent seismic observations of stick‐slip motion at the ice‐bed interface.
J. Umlauft +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source