Results 141 to 150 of about 163,843 (288)

Access to mechanical thrombectomy for stroke in the UK: the unacceptable postcode lottery

Stroke and Vascular Neurology
Kyriakos Lobotesis, Soma Banerjee, Joseph Kwan, Deborah Lowe, Alan Isaacs   +4 more
doaj   +1 more source

Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging. [PDF]

Aging Cell
Shen X, Wang H, Cao G, Lee Y, Zhu J, Wang LC, Zhao T, Ler SG, Sobota RM, Li R, Young JL.   +10 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis. [PDF]

Adv Sci (Weinh)
Zhang S, Li S, Chen W, Song Q, Zhao H, Wang P, Zhang Y, Liang W, Zheng S, Wang J, Chen W, Zhu Y, Zhang Y.   +12 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2-Modulated Exosome Release. [PDF]

Adv Sci (Weinh)
Jin B, Dong S, Jia Y, Xu Z, Liu P, Ding Z, Liao Y, Zou R, Hu J, Cheng B, Niu L.   +10 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Mechanical memory in cells: mechanisms, effects, and applications in regenerative medicine. [PDF]

Front Bioeng Biotechnol
Bhuyan A, Ahearne M.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Covered Endovascular Reconstruction of the Anonymous Confluence (CERAC): a technical note describing a confluence-preserving endovascular technique. [PDF]

CVIR Endovasc
Corti R, Ambrosi L, Cionfoli N, D'Agostino MA, Quaretti P, Bozzani A.   +5 more
europepmc   +1 more source