Results 171 to 180 of about 163,843 (288)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Extracellular matrix composition and stiffness regulates progesterone responsiveness and decidualization. [PDF]

iScience
Klunk D, Homewood L, Abebayehu D.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Space Jam-Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis. [PDF]

Adv Sci (Weinh)
Vahala D, Lee ZM, Amos SE, Son DW, Byun JH, Navaeipour F, Li J, Metzner KL, Jeong JH, Kim J, Hwang Y, Kennedy BF, Lim KS, Lee HS, Park HW, Choi YS.   +15 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Targeting LOXL4-driven matrix stiffening with acetyldigoxin restores CD8⁺ T cell function in lung cancer. [PDF]

Sci Adv
Gu X, Zhu Y, Xu L, Xu X, Jin K, Cho WC, Fang Q.   +6 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program. [PDF]

Nat Immunol
Postat J, Merino M, Mingarelli AR, Cerf A, Bhagrath A, Patel D, Shen C, Brodbeck J, Tirgar P, Rogers D, Blanc J, Jeyakumar T, Schneider C, Coley S, Giannetti N, DePauw TA, Textor J, Ehrlicher A, Jameson SC, Sharif-Naeini R, Sharma A, Mandl JN.   +21 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Chromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation. [PDF]

EMBO J
D'Annunzio S, Di Santo M, Vitali G, Santomaso L, Michelatti D, Morelli L, Bernardis C, Ariefai M, Nasir S, Lago S, Lunelli L, Testi C, Pontecorvo E, Poli A, Pennacchio FA, Maiuri P, Sanchez E, Genevieve D, Petrolli L, Tarenzi T, Menichetti R, Potestio R, Ruocco G, Zippo A.   +23 more
europepmc   +1 more source