Results 51 to 60 of about 25,857 (298)

Overview on solving stiff problems using one-step methods [PDF]

, 2001
Stiff problems in ordinary differential equations can now be solved more routinely. In the past four decades, many researchers were interested in finding effective stiff solution methods.
Tey, Kai Wean
core  

A New Fixed Coefficient Diagonally Implicit Block Backward Differentiation Formula for Solving Stiff Initial Value Problems

UMYU Scientifica Journal
Stiff initial value problems in ordinary differential equations occur when solution components evolve at varying rates, posing challenges for traditional computational methods.
Hamza Yusuf, Musa Hamisu, Alhassan Buhari   +2 more
doaj   +1 more source

On overcoming Dahlquist’s second barrier for$A$-stable linear multistep methods [PDF]

Iranian Journal of Numerical Analysis and Optimization
Dahlquist’s second barrier limits the order of $A$-stable linear multistep methods to at most two, posing significant challenges for achieving higher accuracy in the numerical solution of stiff ordinary differential equations.
G. Hojjati, S. Fazeli, A. Moradi
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Constructing of linearly implicit schemes which are LN-equivalent to implicit Runge-Kutta methods [PDF]

Компьютерные исследования и моделирование, 2012
New family of linearly implicit schemes are presented. This family allows to obtain methods which are equivalent to stiffly accurate implicit Runge-Kutta schemes (such as RadauIIA and LobattoIIIC) on nonautonomous linear problems.
Aleksei Mikhailovich Zubanov, Nikolay N. Kutruhin, Petr Dmitrievich Shirkov   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Adaptive Numerical Method for Approximation of Traffic Flow Equations

Journal of Advanced Transportation, 2022
For a long time now, traffic equations have been considered, and different modeling has been done for it. In this article, we work on the macroscopic model, especially the most famous light model.
Neda Najafzadeh, Saeid Abbasbandy, Elyas Shivanian   +2 more
doaj   +1 more source