Results 61 to 70 of about 4,827,245 (289)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Weighted Iterative Operator-Splitting Methods for stiff problems and applications [PDF]
, 2006 In this paper we describe advanced operator-splitting methods for more accurate and exact decoupling of stiff systems. We deal with stiff operators and contribute for both stiff operators a new weighted iterative operator-splitting method.
Kravvaritis, Christos, Geiser, Jürgen
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The problem of machine stiffness revisited
Geophysical Research Letters, 1991 The notion of “size effect” is introduced into the problem of machine stiffness by assuming that the rock specimen fails according to the slip‐weakening fracture model. Consequently, when the strain energy (stored per unit volume) in the machine and specimen is greater than the fracture energy (dissipated per unit area) of the rock, an unstable ...
openaire +1 more source
, 2020 Explicit stabilized methods are an efficient and powerful alternative to implicit schemes for the time integration of stiff systems of differential equations in large dimensions.
Almuslimani, Ibrahim
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Effects of Postactivation Potentiation After an Eccentric Overload Bout on Countermovement Jump and Lower-Limb Muscle Strength [PDF]
, 2019 Beato, M, Stiff, A, and Coratella, G. Effects of postactivation potentiation after an eccentric overload bout on countermovement jump and lower-limb muscle strength. J Strength Cond Res XX(X): 000-000, 2018-This study aimed to evaluate the postactivation
Coratella, Giuseppe +2 more
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
AxiomsIn this paper, we compare the performances of two Butcher-based block hybrid methods for the numerical integration of initial value problems. We compare the condition numbers of the linear system of equations arising from both methods and the absolute ...
Richard Olatokunbo Akinola +4 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source