Results 81 to 90 of about 4,827,245 (289)

Frozen shoulder – A stiff problem that requires a flexible approach

Maturitas, 2014
Frozen shoulder is a specific, painful and debilitating condition effecting patients mainly in middle age. While it has been recognised for over 100 years, it is still mis-diagnosed, with a natural history that is poorly understood and with limited evidence for the efficacy for various treatments.
P.M. Guyver, D.J. Bruce, J.L. Rees
openaire   +3 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Stiff-Stilbene Ligands Target G-Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity

, 2019
G-quadruplex nucleic acid structures have long been studied as potential anticancer targets while their potential in antiparasitic therapy has only recently been recognized but barely explored. Herein we report the synthesis, biophysical characterization
M. Carmen Galan (7133771), pablo Peñalver (8157964), Rosina S. L. Gibson (8157966), Michael O'Hagan (8157962), Juan Carlos Morales (8157969)   +4 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Super class of implicit extended backward differentiation formulae for the numerical integration of stiff initial value problems [PDF]

Computational Algorithms and Numerical Dimensions
An implicit Superclass of non-block Extended Backward Differentiation Formulae (SEBDF) for the numerical integration of first-order stiff system of Ordinary Differential Equations (ODEs) in Initial Value Problems (IVPs) with optimal stability properties ...
Hamisu Musa, Buhari Alhassan
doaj   +1 more source

Solving stiff problems using generalized picard iteration

, 2009
The main point of the talk is an alternative approach to the construction of numerical methods for stiff problems. It can be interpreted as a generalization of fixed-point iterations for implementation of implicit collocation methods.
Mandrik, P. A., Repnikov, V. I., Faleichik, B. V., Bobkov, V. V.   +3 more
core  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Explicit complex time integrators for stiff problems

CoRR
Most numerical methods for time integration use real-valued time steps. Complex time steps, however, can provide an additional degree of freedom, as we can select the magnitude of the time step in both the real and imaginary directions. We show that specific paths in the complex time plane lead to expanded stability regions, providing clear ...
Jithin D. George, Julian Koellermeier, Samuel Y. Jung, Niall M. Mangan   +3 more
openaire   +2 more sources

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source