Results 91 to 100 of about 81,429 (302)
Partitioning techniques and their parallelization for stiff system of ordinary differential equations [PDF]
, 2007 A new code based on variable order and variable stepsize component wise partitioning is introduced to solve a system of equations dynamically. In previous partitioning technique researches, once an equation is identified as stiff, it will remain in ...
Othman, Khairil Iskandar
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Dynamic sensitivity analysis of biological systems
BMC Bioinformatics, 2008 Background A mathematical model to understand, predict, control, or even design a real biological system is a central theme in systems biology. A dynamic biological system is always modeled as a nonlinear ordinary differential equation (ODE) system.
Chang Maw, Wang Feng, Wu Wu
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Case Report: Suspected “stiff dog syndrome” in a Maltese dog
Frontiers in Veterinary ScienceA Maltese dog was presented with a stiff gait, secondary to muscle hypertonicity, affecting the axial and proximal appendicular muscles, which had progressively worsened over the last 4 years, associated with episodes of muscle spasms.
Valentina Buffagni +6 more
doaj +1 more source
Preliminary system identification studies with the stiff wing mini MUTT Fenrir [PDF]
, 2015 A short successful flight test with the stiff wing mini MUTT, named Fenrir, was conducted on 9 February 2015. The purpose of this flight was to gather preliminary data for system identification focused on low frequency rigid body dynamics.NASA NRA ...
Danowsky, Brian
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Understanding the role of autoencoders for stiff dynamical systems using information theory
Energy and AIUsing information theory, this study provides insights into how the construction of latent space of autoencoder (AE) using deep neural network (DNN) training finds a smooth (non-stiff) low-dimensional manifold in the stiff dynamical system.
Vijayamanikandan Vijayarangan +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Quadrature Methods for Stiff Ordinary Differential Systems [PDF]
Mathematics of Computation, 1981 The quadrature methods are based upon a substitution of an explicit A -stable first approximation into a generalized convolution formula. They are A -stable, explicit, and of arbitrarily high order. The generalized convolution formula is derived and its
openaire +2 more sources