Results 161 to 170 of about 9,010,138 (290)

From force to fate: Implications of mechanomemory in lung disease. [PDF]

Respir Res
Campo-Ortiz de Zárate N, Exojo-Ramírez SM, Albaiceta GM, Chacón M.   +3 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Mechanical memory in cells: mechanisms, effects, and applications in regenerative medicine. [PDF]

Front Bioeng Biotechnol
Bhuyan A, Ahearne M.
europepmc   +1 more source

Advanced Stiff Systems Detection

Acta Electrotechnica et Informatica, 2011
Václav Šátek, Jiří Kunovský, Jan Kopřiva   +2 more
openaire   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM. [PDF]

APL Bioeng
Jiang H, Malayath G, Devi ND, Chou HC, Kargar Gaz Kooh Y, Guo J, Ramahdita G, Nguyen J, Bhakta R, Aryan L, Cresci S, Huebsch N.   +11 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging. [PDF]

Aging Cell
Shen X, Wang H, Cao G, Lee Y, Zhu J, Wang LC, Zhao T, Ler SG, Sobota RM, Li R, Young JL.   +10 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Machine learning-driven optimization of high-velocity impact resistance for three-dimensional biphasic composites. [PDF]

Nat Commun
Bu L, Wang P, Hao S, Li S, Wu Y, Wang D, Liu M, Luo T, Xu S.   +8 more
europepmc   +1 more source