Results 101 to 110 of about 1,742 (234)

RNA‐DNA Fusomer Fibers With Customizable Physicochemical, Mechanical, and Biological Properties for Next‐Generation Therapeutics

Small, EarlyView.
ABSTRACT We introduce RNA‐DNA fusomers, a new class of chemically synthesized oligonucleotides that combine the versatile properties of RNA and DNA within a single sequence and self‐assemble into higher‐order functional structures via a simple one‐pot annealing reaction.
Yasmine Radwan, Laura P. Rebolledo, Yelixza I. Avila, Elizabeth Skelly, Lauren Rackley, Julio Navas Hernandez, Renata de Freitas Saito, Laxmi K. Pandey, Hemani Chhabra, Alexander J. Lushnikov, Tatiane Katsue Furuya, Ana Luiza Lomba, Da Shi, Edward Cedrone, Ian Marriott, Morgan R. Chandler, Meni Wanunu, Aleksei Aksimentiev, Alexey V. Krasnoslobodtsev, Roger Chammas, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The clashing of in situ and pre‐cast technologies—Western trends and local traditions in concrete engineering shaping shell construction in 20th‐century Hungary

Structural Concrete, EarlyView.
Abstract After a blossoming pre‐World War II (WWII) period, the concrete construction industry in then‐socialist Hungary existed in a relative isolation from the Western World during the mid‐20th century. In this paper, we focus on the body of work of one of the then newly established state‐owned design offices, IPARTERV, to show how the isolation ...
Orsolya Gáspár, Péter Haba
wiley   +1 more source

Numerically efficient mechanical modeling of reinforced concrete membrane elements with fixed, interlocked cracks

Structural Concrete, EarlyView.
Abstract Compression field approaches such as the Cracked Membrane Model with fixed, interlocked cracks (CMM‐F) are efficient tools for the mechanical modeling of reinforced concrete elements, providing the mechanical model σ=fε$$ \boldsymbol{\upsigma} =f\left(\boldsymbol{\upvarepsilon} \right) $$ required for finite element analyses.
Andreas Näsbom, Karel Thoma, Walter Kaufmann   +2 more
wiley   +1 more source

Influence of the patch loading length on the buckling coefficient of longitudinally stiffened plate girders

Revista Facultad de Ingeniería Universidad de Antioquia, 2019
Currently, one of the most used steel bridge assembly methods is the Incremental Launching Method (ILM). Its practical application consists in passing the bridge assembly through a launching shoe as well as over each support pile.
Nelson Loaiza, Carlos Graciano, Rolando Chacón   +2 more
doaj  

Simple and detailed modeling of corrosion‐affected slender shear critical RC beams

Structural Concrete, EarlyView.
Abstract The corrosion of steel bars compromises both the safety and the serviceability of reinforced concrete (RC) structures. Consequently, reliable tools are required to estimate the detrimental effects of corrosion on the structural response of RC members subjected to transverse loads.
Nino Spinella, Pier Paolo Rossi
wiley   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Extracellular fluid viscosity influences the mechanics and migration of MDA‐MB‐231 cells in a macromolecule‐dependent manner

The FEBS Journal, EarlyView.
Macromolecule‐dependent increases in extracellular fluid viscosity alter cell phenotype. These distinct macromolecules create different extracellular environments that modulate cell morphology and mechanoprotein expression, migration and invasion capacity, and cellular mechanical properties.
Ian M. Smith, Nikka Givpoor, Chenchen Handler, Ariel Abraham, Shohini Banerjee, Giuliano Scarcelli, Kimberly M. Stroka   +6 more
wiley   +1 more source