The MCPH7 Gene Product STIL Is Essential for Dendritic Spine Formation [PDF]
CellsDendritic spine formation/maintenance is highly dependent on actin cytoskeletal dynamics, which is regulated by small GTPases Rac1 and Cdc42 through their downstream p21-activated kinase/LIM-kinase-I/cofilin pathway.
Tohru Matsuki +8 more
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The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]
Open Biology, 2018 Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint +2 more
exaly +2 more sources
STIL Overexpression Is Associated with Chromosomal Numerical Abnormalities in Non-Small-Cell Lung Carcinoma Through Centrosome Amplification [PDF]
Current OncologySTIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. However, its role in non-small-cell lung carcinoma (NSCLC) remains unclear. In this study, we examined
Shunsuke Ohtsuka +14 more
doaj +2 more sources
Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer [PDF]
Breast Cancer ResearchBackground Recent trials have integrated immune checkpoint inhibitors (ICIs) into neoadjuvant chemotherapy (NAC) in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer of histologic grade (
Seung Ho Baek +6 more
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Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness [PDF]
Kaohsiung Journal of Medical SciencesThe incidence and development of various tumors, such as hepatocellular carcinoma (HCC), are linked to tumor stem cells. Although research has revealed how important SCL/TAL1 interruption site (STIL) is in many human tumors, the impact of STIL on HCC ...
Zhi‐Zhong Zhang +5 more
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Plk4-dependent phosphorylation of STIL is required for centriole duplication
Biology Open, 2015 Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Ingrid Hoffmann
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Role of Ultrasonographic and Clinicopathological Characteristics in Assessing Stromal Tumor-Infiltrating Lymphocyte Density in Triple-Negative Breast Cancer [PDF]
Balkan Medical JournalBackground: A high density of stromal tumor-infiltrating lymphocytes (sTILs) is positively correlated with the pathological complete response rate and favorable survival in patients with triple-negative breast cancer (TNBC).
Lian Li, Yingjia Li
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Homozygous STIL Mutation Causes Holoprosencephaly and Microcephaly in Two Siblings [PDF]
PLoS ONE, 2015 Holoprosencephaly (HPE) is a frequent congenital malformation of the brain characterized by impaired forebrain cleavage and midline facial anomalies. Heterozygous mutations in 14 genes have been identified in HPE patients that account for only 30% of HPE
Marie De Tayrac +2 more
exaly +2 more sources
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development [PDF]
Cell DivisionBackground Dysregulation of SF3A3 has been related to the development of many cancers. Here, we investigated the functional role of SF3A3 in hepatocellular carcinoma (HCC). Methods SF3A3 expression in HCC tissues and cell lines was examined using RT-qPCR.
Haijun Zhang, Lin Zhang, Ziqi Wu
doaj +2 more sources
In silico prediction of a disease‐associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ) [PDF]
FEBS Open Bio, 2012 Rituraj Purohit
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