Results 101 to 110 of about 43,138 (232)

An eikonal model with re‐excitability for fast simulations in cardiac electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Restitution properties obtained from cable‐equation simulations and anisotropic remeshing informed by local fibre orientation are combined in an eikonal model with re‐excitability. The resulting reduced electrophysiology model enables efficient simulations of recurrent activation patterns, here illustrated by atrial re‐entry ...
Lia Gander, Rolf Krause, Francisco Sahli Costabal, Simone Pezzuto   +3 more
wiley   +1 more source

Up-regulation of blood-circulating TIM-4-expressing monocytes and potential diagnostic biomarker sTIM-4 in primary liver cancer

Scientific Reports
Primary hepatocellular carcinoma (PHC) remains a globally prevalent malignancy, where early diagnosis is critical. Monocytes have been implicated in tumor progression.
Yifeng Yang, Yan Wei, Yilian Zhao, Chao Ye, Dan Zeng, Xiaoxing Zhou, Mengru Xie, Xingcai Chen, Jilin Qing, Zhizhong Chen   +9 more
doaj   +1 more source

STIM and ORAI proteins in the nervous system [PDF]

Channels, 2015
Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the endoplasmic reticulum. Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3.
openaire   +2 more sources

Relevance of STIM/Orai Calcium Entry System Hyperactivation in Human Prostate Contractility in Benign Prostate Hyperplasia [PDF]

Benign prostate hyperplasia (BPH) is characterized by prostate enlargement and dynamic alterations contributing to development of lower tract urinary symptoms (LUTS). Prostate hypercontractility has been proposed to contribute to BPH-related LUTS.
José M. La Fuente, Rodríguez-Mañas, Leocadio, Argentina Fernández, El Assar, Mariam, Javier Angulo, La Fuente, José M., Fernández, Argentina, Angulo, Javier, Mariam El Assar, Leocadio Rodríguez-Mañas   +9 more
core   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Novel multimodal mechanical stimulation is superior to TENS to treat and prevent chronic low back pain: a randomized controlled trial

Frontiers in Pain Research
BackgroundLow back pain (LBP) is the leading cause of disability worldwide. Up to half of moderate-to-severe acute LBP (aLBP) progress to chronic (cLBP), with neuromotor, fascial, and muscle pathology contributing to inoperable mechanical disability.
Amy Lynn Baxter, Amy Lynn Baxter, Jena L. Etnoyer-Slaski, Owen Tucker, Jessica Allia Rice Williams, Kevin Swartout, Lindsey L. Cohen, M. Louise Lawson   +7 more
doaj   +1 more source

The remote allosteric control of Orai channel gating.

PLoS Biology, 2019
Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth. The ubiquitously expressed Orai family of plasma membrane (PM) ion channels mediate Ca2+ entry signals triggered by ...
Yandong Zhou, Robert M Nwokonko, James H Baraniak, Mohamed Trebak, Kenneth P K Lee, Donald L Gill   +5 more
doaj   +1 more source

Anti-Inflammatory Effects of Non-Antibiotic Alternatives in Coccidia Challenged Broiler Chickens

The Journal of Poultry Science, 2014
This study was conducted to determine the effect of selected antibiotic alternatives on growth performance and inflammatory gene expression in broiler chickens challenged with Eimeria oocysts from Coccivac® vaccine.
Hang Lu, Sunday A. Adedokun, Layi Adeola, Kolapo M. Ajuwon   +3 more
doaj   +1 more source

Localization of STIM-1 and Orai-1 in DC.

, 2013
The expression of Orai-1 and STIM-1 was analyzed at the transcriptional (A and B) or translational (C) level. Quantitative RT-PCR analysis of Orai-1 (A) and STIM-1 (B) mRNA showed their expression profile for different maturating stimuli (mean ± SD). The
Jérémy Fauconnier (586768), Jean-Yves Le Guennec (314450), Yvon Lebranchu (94195), Romain Félix (586765), David Crottès (586766), Anthony Delalande (586767), Florence Velge-Roussel (94194)   +6 more
core   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source