Results 1 to 10 of about 19,901 (120)

Level of serum soluble Tim-3 expression in early-phase acute pancreatitis [PDF]

The Turkish Journal of Gastroenterology, 2019
Background/Aims: T-cell immunoglobulin and mucin domain 3 (Tim-3) assumedly play a crucial immunomodulatory role in inflammatory response. Data on the potential role of soluble Tim-3 (sTim-3) in acute pancreatitis (AP) are scarce.
Min Lin, Jin Huang, Jian Huang, Sheng-lan Liu, Wei-Chang Chen   +4 more
doaj   +7 more sources

Increase in Serum Soluble Tim-3 Level Is Related to the Progression of Diseases After Hepatitis Virus Infection [PDF]

Frontiers in Medicine, 2022
BackgroundViral hepatitis is a widespread and serious infectious disease, and most patients with liver cirrhosis and hepatocellular carcinoma are prone to viral infections. T cell immunoglobulin-and mucin-domain-containing molecule-3 (Tim-3) is an immune
Lingli Chen, Xiaomei Yu, Chunyan Lv, Yaping Dai, Tao Wang, Shaoxiong Zheng, Yuan Qin, Xiumei Zhou, Yigang Wang, Hao Pei, Hongming Fang, Biao Huang   +11 more
doaj   +6 more sources

Prognostic Role of Serum Soluble Tim-3 in Severe Traumatic Brain Injury: A Prospective Observational Study [PDF]

Neuropsychiatric Disease and Treatment, 2023
Han Zhang, Qing-Wei Lv, Zi-Qiang Zheng, Liang-Jun Shen, Jing Zhou, Mi Guo Department of Neurosurgery, Shengzhou People’s Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch), Shengzhou, People’s Republic of ChinaCorrespondence:
Zhang H, Lv QW, Zheng ZQ, Shen LJ, Zhou J, Guo M   +5 more
doaj   +5 more sources

Soluble TIM-3 and galectin-9 predict survival in gastric and gastroesophageal junction cancer [PDF]

iScience
Summary: Current biomarkers for diagnosis and prognosis prediction in gastric cancer (GC) and gastroesophageal junction (GEJ) cancer have limited accuracy, and the role of soluble immune checkpoints is unknown.
David Digomann, Charlotte Reiche, Antonia Stammberger, Tido Willms, Loreen S. Rudek, Anders Grabenkamp, Anna Klimova, Jamie Kölbel, Felix Merboth, Loreen Natusch Bufe, Carolin Beer, Therés Golle, Sarah Cronjaeger, Franziska Hoffmann, Luisa Kranich, Marc Schmitz, Christiane J. Bruns, Hans A. Schlößer, Jürgen Weitz, Lena Seifert, Adrian M. Seifert   +20 more
doaj   +4 more sources

Elevated Serum Soluble Tim-3 in Primary Biliary Cholangitis: Lack of Correlation with Cytokines, Chemokines, and Clinical Parameters [PDF]

The Turkish Journal of Gastroenterology
Background/Aims: Soluble Tim-3 (sTim-3) has been implicated in primary biliary cholangitis (PBC), an autoimmune liver disease, though its clinical significance remains unclear.
Jiamin Xu, Haitao Ma, Futao Dang, Hua Lin, Chenrui Zhang, Qian Wang, Xu Tan, Xian Yang, Jingyi Zhang, Weimin Bao, Yingmei Tang   +10 more
doaj   +5 more sources

Elevated soluble Tim-3 correlates with disease activity of systemic lupus erythematosus

Autoimmunity, 2021
T cell immunoglobulin and mucin domain-containing molecule-3(Tim-3) has been found to play important roles in systemic lupus erythematosus (SLE), but whether sTim-3 is involved in the development of SLE remains unknown. In this study, we firstly observed
Di Zhao, Chunhao Li, Xiao Yang, Wenjiang Yan, Yi Zhang   +4 more
doaj   +4 more sources

Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection [PDF]

Cancer Management and Research, 2018
Fang Li,1 Na Li,1 Jiao Sang,1 Xiude Fan,1 Huan Deng,1 Xiaoge Zhang,1 Qunying Han,1 Yi Lv,2,3 Zhengwen Liu1,3 1Department of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; 2Department of ...
Li F, Li N, Sang J, Fan X, Deng H, Zhang X, Han Q, Lv Y, Liu Z   +8 more
doaj   +6 more sources

Soluble TIM-3, likely produced by myeloid cells, predicts resistance to immune checkpoint inhibitors in metastatic clear cell renal cell carcinoma [PDF]

Journal of Experimental & Clinical Cancer Research
Background Immunotherapies targeting PD-1 and CTLA-4 are key components of the treatment of metastatic clear cell renal cell carcinoma (mccRCC). However, they have distinct safety profiles and resistance to treatment can occur.
Ivan Pourmir, Nadine Benhamouda, Thi Tran, Hugo Roux, Joséphine Pineau, Alain Gey, Andyara Munoz, Nesrine Mabrouk, Nicolas Epaillard, Virginie Verkarre, Yann-Alexandre Vano, Eric Tartour, Stéphane Oudard   +12 more
doaj   +4 more sources

Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases

Biochemical Pharmacology, 2023
Immune checkpoints inhibition is a privileged approach to combat cancers and other human diseases. The TIM-3 (T cell immunoglobulin and mucin-domain containing-3) inhibitory checkpoint expressed on different types of immune cells is actively investigated as an anticancer target, with a dozen of monoclonal antibodies in (pre)clinical development.
Laurence Goossens, Christian Bailly
exaly   +4 more sources

Serum soluble Tim‑3 is elevated in patients with cervical cancer and is higher in advanced clinical stages. [PDF]

Biomed Rep
T-cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) is an immune checkpoint molecule that is expressed generally on the cell membrane of immune and cancer cells and is implicated as a negative regulator of anti-tumour immune responses; this occurs through the interaction of Tim-3 with galectin-9.
Conde-Rodríguez I, Pérez-Picazo S, Vázquez-Zamora VJ, Reyes-Leyva J, Vallejo-Ruiz V.   +4 more
europepmc   +3 more sources