Results 41 to 50 of about 20,000 (219)

Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients [PDF]

Frontiers in Oncology, 2022
Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers. Intracellular oxidative stress has also been proposed as a contributor to the occurrence of skin cancers.
Mahlatse C. M. Kgokolo, Katherine Anderson, Shalate C. Siwele, Helen C. Steel, Luyanda L. I. Kwofie, Luyanda L. I. Kwofie, Mike M. Sathekge, Pieter W. A. Meyer, Pieter W. A. Meyer, Bernardo L. Rapoport, Bernardo L. Rapoport, Ronald Anderson   +11 more
openaire   +4 more sources

Sabatolimab (MBG453) model‐informed drug development for dose selection in patients with myelodysplastic syndrome/acute myeloid leukemia and solid tumors

CPT: Pharmacometrics & Systems Pharmacology, 2023
Sabatolimab is a novel immunotherapy with immuno‐myeloid activity that targets T‐cell immunoglobulin domain and mucin domain‐3 (TIM‐3) on immune cells and leukemic blasts.
Siyan Xu, Na Zhang, Mikael L. Rinne, Haiying Sun, Andrew M. Stein   +4 more
doaj   +1 more source

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

EBioMedicine, 2017
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells.
Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev   +14 more
doaj   +1 more source

Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice [PDF]

Human Vaccines & Immunotherapeutics, 2013
The development of an effective T cell based HIV vaccine would need to elicit cell mediated immune responses with superior magnitude, breadth, and quality. Since blocking the interactions between inhibitory receptors with their associated ligands using soluble PD-1 (sPD-1) and soluble Tim-3 (sTim-3) have been shown to reverse T cell exhaustion and ...
Lijun, Xiao, Dimin, Wang, Caijun, Sun, Pingchao, Li, Yi, Jin, Liqiang, Feng, Ling, Chen   +6 more
openaire   +2 more sources

Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis

Frontiers in Immunology, 2022
Altered expression of adhesion molecules in immune cells has been demonstrated in rheumatoid arthritis (RA). Carcinoembryonic–antigen–related cell–adhesion molecule 1 (CEACAM1) is an adhesion molecule that acts as a coinhibitory receptor in the immune ...
Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita   +14 more
doaj   +1 more source

Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1, and TIM-3 are markedly increased in basal cell carcinoma.

Journal of Clinical Oncology, 2022
3043 Background: Although co-inhibitory immune checkpoint proteins are primarily involved in promoting inhibitory cell-cell interactions in adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules are also detectable in the circulation of cancer patients where they retain immunosuppressive activity. Nevertheless,
Malinga, Nonkululeko Z., Siwele, Shalate C., Steel, Helen C., Kwofie, Luyanda Laura Illicia, Meyer, Pieter Willem Adriaan, Smit, Teresa, Anderson, Ronald, Rapoport, Bernardo Leon, Kgokolo, C.M.   +8 more
openaire   +4 more sources

Preliminary Results of a Combined Score Based on sIL2-Rα and TIM-3 Levels Assayed Early After Hematopoietic Transplantation

Frontiers in Immunology, 2020
Assays of cytokines in the plasma at the onset of graft-vs. -host disease (GVHD) can predict disease severity and treatment-related mortality (TRM); however, the optimal time during which cytokines should be tested and the specific panel of cytokines ...
Salvatore Leotta, Giuseppe Sapienza, Maria Grazia Camuglia, Giuseppe Avola, Annalia Di Marco, Gaetano Moschetti, Angelo Curto Pelle, Uros Markovic, Giulio Antonio Milone, Alessandra Cupri, Oriana Bianco, Viviana Frontini, Andre Spadaro, Anna Elisa Marchese, Roberto Crocchiolo, Giuseppe Milone   +15 more
doaj   +1 more source

Serum Concentrations of TIM-3, LAG-3, and PD-1 in Patients with Hemorrhagic Fever with Renal Syndrome

Life
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease widespread in Europe and Asia. HFRS is caused by negative-sensed single-stranded RNA orthohantaviruses transmitted to humans through inhaling aerosolized excreta of infected rodents ...
Željka Mačak Šafranko, Lana Jakopec, Karla Svaguša, Lidija Cvetko Krajinović, Domagoj Tomasović, Ljiljana Lukić, Alemka Markotić   +6 more
doaj   +1 more source

Soluble immune checkpoint molecules in patients with antineutrophil cytoplasmic antibody-associated vasculitis

Scientific Reports, 2022
Immune checkpoint molecules balance immune effector responses with regulatory reactions. We speculated that soluble immune checkpoint molecules are involved in dysregulation of the immune response and autoimmunity.
Jung Yoon Pyo, Taejun Yoon, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source