Results 41 to 50 of about 19,003,286 (253)

Sabatolimab (MBG453) model‐informed drug development for dose selection in patients with myelodysplastic syndrome/acute myeloid leukemia and solid tumors

CPT: Pharmacometrics & Systems Pharmacology, 2023
Sabatolimab is a novel immunotherapy with immuno‐myeloid activity that targets T‐cell immunoglobulin domain and mucin domain‐3 (TIM‐3) on immune cells and leukemic blasts.
Siyan Xu, Na Zhang, Mikael L. Rinne, Haiying Sun, Andrew M. Stein   +4 more
doaj   +1 more source

Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients [PDF]

Frontiers in Oncology, 2022
Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers. Intracellular oxidative stress has also been proposed as a contributor to the occurrence of skin cancers.
Mahlatse C. M. Kgokolo, Katherine Anderson, Shalate C. Siwele, Helen C. Steel, Luyanda L. I. Kwofie, Luyanda L. I. Kwofie, Mike M. Sathekge, Pieter W. A. Meyer, Pieter W. A. Meyer, Bernardo L. Rapoport, Bernardo L. Rapoport, Ronald Anderson   +11 more
openaire   +4 more sources

10XTYPES Vol.3

Typeface archive book featuring ten typefaces design by Tim Hutchinson. Each typeface is displayed as a full specimen throughout the book plus some experimental & live application of selected typefaces at the end of the ...
Hutchinson, Tim
core   +4 more sources

Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice [PDF]

Human Vaccines & Immunotherapeutics, 2013
The development of an effective T cell based HIV vaccine would need to elicit cell mediated immune responses with superior magnitude, breadth, and quality. Since blocking the interactions between inhibitory receptors with their associated ligands using soluble PD-1 (sPD-1) and soluble Tim-3 (sTim-3) have been shown to reverse T cell exhaustion and ...
Lijun, Xiao, Dimin, Wang, Caijun, Sun, Pingchao, Li, Yi, Jin, Liqiang, Feng, Ling, Chen   +6 more
openaire   +2 more sources

Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis

Frontiers in Immunology, 2022
Altered expression of adhesion molecules in immune cells has been demonstrated in rheumatoid arthritis (RA). Carcinoembryonic–antigen–related cell–adhesion molecule 1 (CEACAM1) is an adhesion molecule that acts as a coinhibitory receptor in the immune ...
Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita   +14 more
doaj   +1 more source

Soluble TIM-3 (sTIM-3) and breast cancer

, 2022
O câncer de mama é a neoplasia maligna que apresenta maior mortalidade em mulheres no Brasil. Assim, nos últimos anos, busca-se por novos marcadores diagnósticos e novas opções de tratamentos que possibilitem melhora dos resultados clínicos e redução ...
Aguiar, Laura Maciel Rocha Penteado de
core   +1 more source

Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1, and TIM-3 are markedly increased in basal cell carcinoma.

Journal of Clinical Oncology, 2022
3043 Background: Although co-inhibitory immune checkpoint proteins are primarily involved in promoting inhibitory cell-cell interactions in adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules are also detectable in the circulation of cancer patients where they retain immunosuppressive activity. Nevertheless,
Malinga, Nonkululeko Z., Siwele, Shalate C., Steel, Helen C., Kwofie, Luyanda Laura Illicia, Meyer, Pieter Willem Adriaan, Smit, Teresa, Anderson, Ronald, Rapoport, Bernardo Leon, Kgokolo, C.M.   +8 more
openaire   +4 more sources

Patients with peripheral artery disease demonstrate altered expression of soluble and membrane-bound immune checkpoints

Frontiers in Immunology
IntroductionStudies suggest that immune checkpoints play a role in accelerating the formation of atherosclerosis. We aimed to assess the expression of soluble and membrane-bound immune checkpoints in patients with peripheral artery disease (PAD ...
Rosanne D. Reitsema, Seta Kurt, Seta Kurt, Ignacio Rangel, Hans Hjelmqvist, Hans Hjelmqvist, Mats Dreifaldt, Allan Sirsjö, Ashok Kumar Kumawat   +8 more
doaj   +1 more source

Preliminary Results of a Combined Score Based on sIL2-Rα and TIM-3 Levels Assayed Early After Hematopoietic Transplantation

Frontiers in Immunology, 2020
Assays of cytokines in the plasma at the onset of graft-vs. -host disease (GVHD) can predict disease severity and treatment-related mortality (TRM); however, the optimal time during which cytokines should be tested and the specific panel of cytokines ...
Salvatore Leotta, Giuseppe Sapienza, Maria Grazia Camuglia, Giuseppe Avola, Annalia Di Marco, Gaetano Moschetti, Angelo Curto Pelle, Uros Markovic, Giulio Antonio Milone, Alessandra Cupri, Oriana Bianco, Viviana Frontini, Andre Spadaro, Anna Elisa Marchese, Roberto Crocchiolo, Giuseppe Milone   +15 more
doaj   +1 more source

Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy

, 2022
Natural killer (NK) cells help regulate autoimmune reactions, but overactivation causes harm. A Tim-3 receptor is an immune checkpoint that prevents overactivation.
Kumar, Arun, Kumar, Deepak, Sharma, Akshansh, Pandey, Sadanand   +3 more
core   +1 more source