Results 21 to 30 of about 19,003,286 (253)

Immune checkpoint TIM-3 defines hyperactivated NK cells and predicts fatal outcome in severe fever with thrombocytopenia syndrome. [PDF]

PLoS Neglected Tropical Diseases
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with high mortality, primarily driven by immune dysregulation. This study aimed to characterize the expression profile of TIM-3 expression on peripheral NK cells in
Xiaohan Qian, Yi Zhang, Ziling Cheng, Haolin Song, Lingtong Huang, Bei Jia, Jie Li, Jie Wang, Wei Wu   +8 more
doaj   +2 more sources

Expression of Gal-9 on Dendritic Cells and Soluble Forms of TIM-3/Gal-9 in Patients Suffering from Endometriosis

International Journal of Molecular Sciences, 2023
Immune system dysregulation is clinically evident in the pathogenesis of endometriosis (EMS). Changes in the dendritic cells (DCs) activity or phenotype may be involved in the implantation and growth of endometrial tissue outside the uterus in the disease. The TIM-3/Gal-9 axis is implicated in the development of immune tolerance. However, the knowledge
Dorota Suszczyk, Wiktoria Skiba, Anna Pawłowska, Grzegorz Polak, Rafał Tarkowski, Iwona Wertel   +5 more
openaire   +3 more sources

Comparable restimulation of human T cells activated with CD3/CD28 beads versus soluble antibody complexes [PDF]

Scientific Reports
Ex vivo T-cell activation is critical in both basic immunology and clinical applications, such as CAR-T cell therapy. CD3/CD28 antibody-coated beads and soluble antibody complexes are widely used, yet direct comparisons remain limited and often ...
Mégane Jassin, Bianca E Silva, Sandra Ormenese, Frédéric Baron, Grégory Ehx, Jo Caers   +5 more
doaj   +2 more sources

Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels

Scientific Reports
Chronic hepatitis C (CHC), caused by the hepatitis C virus, commonly leads to liver fibrosis. CHC is also related to T-cell exhaustion, phenotypically manifesting as overexpression of inhibitory receptors (iRs), e.g., programmed death receptor-1 (PD-1 ...
Sylwia Osuch, Aleksandra Kumorek, Paweł Kozłowski, Hanna Berak, Anna Maria Kochanowicz, Kamila Cortés-Fendorf   +5 more
doaj   +3 more sources

Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis

Renal Failure, 2023
Objective The present study investigated the specific mechanism by which mesenchymal stem cells (MSCs) protect against sepsis-associated acute kidney injury (SA-AKI).Methods Male C57BL/6 mice underwent cecal ligation and puncture surgery to induce sepsis
Congjuan Luo, Feng Luo, Lin Che, Hui Zhang, Long Zhao, Wei Zhang, Xiaofei Man, Quandong Bu, Hong Luan, Bin Zhou, Haiyan Zhou, Yan Xu   +11 more
doaj   +1 more source

Dynamics of the inhibitory immune checkpoint TIM-3 in mouse pulmonary phagocytes after silica exposure

Ecotoxicology and Environmental Safety, 2023
Long-term inhalation of silica particles in the workplace causes silicosis, which is incurable and seriously endangers the health of workers. It is believed that silicosis is caused by an imbalance of the pulmonary immune microenvironment, in which ...
Youliang Zhao, Yaqian Qu, Meixiu Duan, Changfu Hao, Wu Yao   +4 more
doaj   +1 more source

Recombinant human TIM-3 ectodomain expressed in bacteria and recovered from inclusion bodies as a stable and active molecule

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Microbial systems, such as Escherichia coli, as host recombinant expression is the most versatile and the cheapest system for protein production, however, several obstacles still remain, such as recovery of soluble and functional proteins ...
G. C. Lima, R. M. Chura-Chambi, L. Morganti, V. J. Silva, M. P. Cabral-Piccin, V. Rocha, V. Rocha, T. S. Medina, R. N. Ramos, R. N. Ramos, D. Luz   +10 more
doaj   +1 more source

10xTYPES Vol 2

, 2023
Typeface archive book featuring ten typefaces design by Tim Hutchinson. Each typeface is displayed as a full specimen throughout the book plus some experimental & live application of selected typefaces at the end f the ...
Hutchinson, Tim
core   +4 more sources

High Levels of TNF-α and TIM-3 as a Biomarker of Immune Reconstitution Inflammatory Syndrome in People with HIV Infection

Life, 2021
Immune reconstitution inflammatory syndrome (IRIS) is an exacerbated immune response that can occur to HIV+ patients after initiating antiretroviral therapy (ART).
Lucero A. Ramon-Luing, Ranferi Ocaña-Guzman, Norma A. Téllez-Navarrete, Mario Preciado-García, Dámaris P. Romero-Rodríguez, Enrique Espinosa, Gustavo Reyes-Terán, Leslie Chavez-Galan   +7 more
doaj   +1 more source

Serum soluble T cell immunoglobulin mucin domain-3 as an early predictive marker for severity of acute pancreatitis; a retrospective analysis

BMC Gastroenterology, 2022
Background Early prediction of severe acute pancreatitis (SAP) plays an important role in timely treatment decisions. Soluble T cell immunoglobulin and mucin domain-3 (sTIM-3) has been applied as a potential biomarker for the prediction of many diseases,
Fushuang Wang, Minghui Zhu, Yao Meng, Min Lin   +3 more
doaj   +1 more source