Results 11 to 20 of about 19,003,286 (253)

A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease [PDF]

Biology of Blood and Marrow Transplantation, 2013
The T cell Ig and mucin domain 3 (Tim-3) receptor has been implicated as a negative regulator of adaptive immune responses. We have utilized a proteomic strategy to identify novel proteins associated with graft versus host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT).
John Hansen, Paul J Martin, Laura Tabellini   +2 more
exaly   +5 more sources

Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection [PDF]

Aids, 2019
: Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found ...
Genevieve Elizabeth Martin, Christian Willberg, John Frater   +2 more
exaly   +7 more sources

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells [PDF]

EBioMedicine, 2017
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells.
Jasmin Wellbrock, Bernhard Gibbs, Luca Varani   +2 more
exaly   +5 more sources

Serum soluble Tim‑3 is elevated in patients with cervical cancer and is higher in advanced clinical stages. [PDF]

Biomed Rep
T-cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) is an immune checkpoint molecule that is expressed generally on the cell membrane of immune and cancer cells and is implicated as a negative regulator of anti-tumour immune responses; this occurs through the interaction of Tim-3 with galectin-9.
Conde-Rodríguez I, Pérez-Picazo S, Vázquez-Zamora VJ, Reyes-Leyva J, Vallejo-Ruiz V.   +4 more
europepmc   +3 more sources

Soluble TIM-3 and galectin-9 serve as additional diagnostic biomarkers in primary central nervous system lymphoma. [PDF]

J Neurol
Background: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive B-cell lymphoma in which early diagnosis remains challenging. Although cerebrospinal fluid (CSF) B-cell-associated factors including soluble interleukin-2 receptor subunit alpha (IL-2RA) are known diagnostic markers, they often reflect neuroinflammation and are ...
Nishii S, Akatani R, Shiroma K, Takeda R, Tsuji A, Katanazaka K, Matoba K, Otani M, Koto S, Tanaka K, Nagashima H, Sekiguchi K, Sasayama T, Chihara N.   +13 more
europepmc   +4 more sources

Tim-3 as a diagnostic and prognostic biomarker of osteosarcoma

Tumor Biology, 2017
Osteosarcoma is the most frequent primary bone tumor that affects adolescents and children. However, diagnostic and prognostic biomarkers for osteosarcoma remain lacking. (Tim-3) T-cell immunoglobulin domain and mucin domain-3, which negatively regulates
Wenhui Ge, Jing Li, Wenhao Fan, Delong Xu, Shangfei Sun   +4 more
doaj   +2 more sources

Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8⁺ T cell exhaustion and anti-PD-1 resistance. [PDF]

Cell Rep Med
Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immunoglobulin and mucin domain containing-3 (Tim-3), a promising immune checkpoint target, is cleaved by ADAM10/17 to produce its soluble form (sTim-3) in humans, potentially becoming involved in anti-PD-1 resistance. Herein, serum sTim-3 upregulation was
Chen C, Zhao F, Peng J, Zhao D, Xu L, Li H, Ma S, Peng X, Sheng X, Sun Y, Wang T, Dong H, Ding Y, Wu Z, Liang X, Gao L, Wang H, Ma C, Li C.   +18 more
europepmc   +3 more sources

Immunopathogenesis of severe pneumonia in children with emphasis on CD4+ T cells, Tim-3 and cytokine-mediated immune dysregulation [PDF]

Frontiers in Medicine
Severe pneumonia in children remains a major cause of hospitalization, respiratory failure and infection-related mortality. Increasing evidence indicates that disease severity is shaped not only by pathogen burden but also by the timing, intensity and ...
Fang Cao, Qi Zhang, Lunan Yan
doaj   +2 more sources

Plasma soluble TIM-3 is increased in normoglycemic South Asian women compared to Nordic women after gestational diabetes mellitus and associated with markers of metaflammation. [PDF]

Heliyon
Women with South Asian ethnicity have a higher risk of developing type 2 diabetes mellitus (T2DM) compared with white women of European descent, especially after gestational diabetes mellitus (GDM). Central obesity and adipose tissue dysfunction have been linked to their higher risk of T2DM, but the mechanisms are not known.
Grannes H, Sharma A, Suntharalingam A, Michelsen AE, Aukrust P, Ueland T, Birkeland KI, Gregersen I, Lee-Ødegård S, Halvorsen B.   +9 more
europepmc   +4 more sources

Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3

Frontiers in Oncology, 2023
Neoadjuvant chemotherapy (NAC) may alter the immune landscape of patients with early breast cancer (BC), potentially setting the scene for more effective implementation of checkpoint-targeted immunotherapy. This issue has been investigated in the current
Bernardo L. Rapoport, Bernardo L. Rapoport, Bernardo L. Rapoport, Helen C. Steel, Carol A. Benn, Carol A. Benn, Simon Nayler, Simon Nayler, Teresa Smit, Liezl Heyman, Annette J. Theron, Nomsa Hlatshwayo, Nomsa Hlatshwayo, Luyanda L.I. Kwofie, Luyanda L.I. Kwofie, Pieter W.A. Meyer, Pieter W.A. Meyer, Ronald Anderson   +17 more
doaj   +4 more sources