Results 11 to 20 of about 20,000 (219)

Soluble TIM-3 and galectin-9 serve as additional diagnostic biomarkers in primary central nervous system lymphoma. [PDF]

J Neurol
Background: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive B-cell lymphoma in which early diagnosis remains challenging. Although cerebrospinal fluid (CSF) B-cell-associated factors including soluble interleukin-2 receptor subunit alpha (IL-2RA) are known diagnostic markers, they often reflect neuroinflammation and are ...
Nishii S, Akatani R, Shiroma K, Takeda R, Tsuji A, Katanazaka K, Matoba K, Otani M, Koto S, Tanaka K, Nagashima H, Sekiguchi K, Sasayama T, Chihara N.   +13 more
europepmc   +3 more sources

A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease [PDF]

Biology of Blood and Marrow Transplantation, 2013
The T cell Ig and mucin domain 3 (Tim-3) receptor has been implicated as a negative regulator of adaptive immune responses. We have utilized a proteomic strategy to identify novel proteins associated with graft versus host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT).
John Hansen, Paul J Martin, Laura Tabellini   +2 more
exaly   +3 more sources

Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients

Frontiers in Immunology, 2022
Thermal injury induces concurrent inflammatory and immune dysfunction, which is associated with adverse clinical outcomes. However, these effects in the pediatric population are less studied and there is no standard method to identify those at risk for ...
Julia A. Penatzer, Robin Alexander, Shan Simon, Amber Wolfe, Julie Breuer, Josey Hensley, Renata Fabia, Mark Hall, Mark Hall, Mark Hall, Rajan K. Thakkar, Rajan K. Thakkar   +11 more
doaj   +3 more sources

Immune checkpoint TIM-3 defines hyperactivated NK cells and predicts fatal outcome in severe fever with thrombocytopenia syndrome. [PDF]

PLoS Neglected Tropical Diseases
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with high mortality, primarily driven by immune dysregulation. This study aimed to characterize the expression profile of TIM-3 expression on peripheral NK cells in
Xiaohan Qian, Yi Zhang, Ziling Cheng, Haolin Song, Lingtong Huang, Bei Jia, Jie Li, Jie Wang, Wei Wu   +8 more
doaj   +2 more sources

Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8⁺ T cell exhaustion and anti-PD-1 resistance. [PDF]

Cell Rep Med
Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immunoglobulin and mucin domain containing-3 (Tim-3), a promising immune checkpoint target, is cleaved by ADAM10/17 to produce its soluble form (sTim-3) in humans, potentially becoming involved in anti-PD-1 resistance. Herein, serum sTim-3 upregulation was
Chen C, Zhao F, Peng J, Zhao D, Xu L, Li H, Ma S, Peng X, Sheng X, Sun Y, Wang T, Dong H, Ding Y, Wu Z, Liang X, Gao L, Wang H, Ma C, Li C.   +18 more
europepmc   +3 more sources

Expression of Gal-9 on Dendritic Cells and Soluble Forms of TIM-3/Gal-9 in Patients Suffering from Endometriosis

International Journal of Molecular Sciences, 2023
Immune system dysregulation is clinically evident in the pathogenesis of endometriosis (EMS). Changes in the dendritic cells (DCs) activity or phenotype may be involved in the implantation and growth of endometrial tissue outside the uterus in the disease. The TIM-3/Gal-9 axis is implicated in the development of immune tolerance. However, the knowledge
Rafał Tarkowski, Grzegorz Polak, Dorota Suszczyk   +2 more
exaly   +3 more sources

Plasma soluble TIM-3 is increased in normoglycemic South Asian women compared to Nordic women after gestational diabetes mellitus and associated with markers of metaflammation. [PDF]

Heliyon
Women with South Asian ethnicity have a higher risk of developing type 2 diabetes mellitus (T2DM) compared with white women of European descent, especially after gestational diabetes mellitus (GDM). Central obesity and adipose tissue dysfunction have been linked to their higher risk of T2DM, but the mechanisms are not known.
Grannes H, Sharma A, Suntharalingam A, Michelsen AE, Aukrust P, Ueland T, Birkeland KI, Gregersen I, Lee-Ødegård S, Halvorsen B.   +9 more
europepmc   +4 more sources

Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3

Frontiers in Oncology, 2023
Neoadjuvant chemotherapy (NAC) may alter the immune landscape of patients with early breast cancer (BC), potentially setting the scene for more effective implementation of checkpoint-targeted immunotherapy. This issue has been investigated in the current
Bernardo L. Rapoport, Bernardo L. Rapoport, Bernardo L. Rapoport, Helen C. Steel, Carol A. Benn, Carol A. Benn, Simon Nayler, Simon Nayler, Teresa Smit, Liezl Heyman, Annette J. Theron, Nomsa Hlatshwayo, Nomsa Hlatshwayo, Luyanda L.I. Kwofie, Luyanda L.I. Kwofie, Pieter W.A. Meyer, Pieter W.A. Meyer, Ronald Anderson   +17 more
doaj   +4 more sources

Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection

Aids, 2019
: Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found ...
Genevieve Elizabeth Martin, Christian Willberg, John Frater   +2 more
exaly   +4 more sources

Patients with peripheral artery disease demonstrate altered expression of soluble and membrane-bound immune checkpoints [PDF]

Frontiers in Immunology
IntroductionStudies suggest that immune checkpoints play a role in accelerating the formation of atherosclerosis. We aimed to assess the expression of soluble and membrane-bound immune checkpoints in patients with peripheral artery disease (PAD ...
Rosanne D. Reitsema, Seta Kurt, Seta Kurt, Ignacio Rangel, Hans Hjelmqvist, Hans Hjelmqvist, Mats Dreifaldt, Allan Sirsjö, Ashok Kumar Kumawat   +8 more
doaj   +2 more sources