Results 31 to 40 of about 20,000 (219)
Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation
Cell Death Discovery, 2023 The impact of Tim-3 (T cell immunoglobulin and mucin domain-containing protein 3) on cisplatin-induced acute kidney injury was investigated in this study.
Peiyao Li +9 more
doaj +1 more source
Journal of Immunology Research, 2023 T-cell Immunoglobulin and Mucin Domain 3 (TIM-3) is an immune checkpoint receptor known to regulate T-cell activation and has been targeted for immunotherapy in cancer and other diseases.
Ranferi Ocaña-Guzman +8 more
doaj +1 more source
Biomedicine Hub, 2021 We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in ...
Alejandro Martín-Quirós +13 more
doaj +1 more source
A Novel Recombinant Fusion Protein with Soluble PD-1 and TIM-3 Domains Effectively Binds to Cancer Cells [PDF]
Indian Journal of Pharmaceutical Sciences, 2020 In this investigation, a DNA sequence was designed and synthesized by joining coding regions of soluble programmed cell death-1 and T-cell immunoglobulin and mucin-3 domains and cloned into the lentiviral expression vector pLVX-IRES-ZsGreen1. After infection of the recombinant lentivirus into HEK 293T cells, the recombinant fusion protein, designated ...
Jing Chen, Jun Wu, Jiang Cao
openaire +1 more source
Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3) [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition.
Vida Homayouni +5 more
doaj +1 more source
Changes in serum TIM-3 and complement C3 expression in workers due to Mn exposure
Frontiers in Public Health, 2023 Mn (Manganese, Mn) is an essential trace element involved in various biological processes such as the regulation of immune, nervous and digestive system functions. However, excessive Mn exposure can lead to immune damage.
Yuanmeng Qi +10 more
doaj +1 more source
Association between inflammatory cytokines and immune-checkpoint molecule in rheumatoid arthritis.
PLoS ONE, 2021 BackgroundAnti-citrullinated peptide antibodies (ACPA) and inflammatory cytokines play important roles in the development of rheumatoid arthritis (RA). T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune-checkpoint molecule involved ...
Haruki Matsumoto +13 more
doaj +2 more sources
Tim-3 as a diagnostic and prognostic biomarker of osteosarcoma
Tumor Biology, 2017 Osteosarcoma is the most frequent primary bone tumor that affects adolescents and children. However, diagnostic and prognostic biomarkers for osteosarcoma remain lacking. (Tim-3) T-cell immunoglobulin domain and mucin domain-3, which negatively regulates
Wenhui Ge +4 more
doaj +1 more source
Noninvasive detection of acute renal allograft rejection by measurement of soluble Tim-3 in urine
Molecular Medicine Reports, 2017 The purpose of the present study was to assess whether urinary soluble T-cell immunoglobulin and mucin domain-containing protein 3 (sTim-3) could be adopted as a novel non‑invasive biomarker for acute rejection (AR) following renal transplantation. A total of 156 patients were enrolled between January 2006 and December 2009, comprising 49 patients with
Dajin, Chen +6 more
openaire +3 more sources
PLoS Pathogens, 2012 T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain poorly understood.
Yueqin Qiu +17 more
doaj +1 more source