Results 71 to 80 of about 5,580,781 (423)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Frontiers in Neuroscience, 2021
Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques.
Leo K. Cheng, Leo K. Cheng, Leo K. Cheng, Nipuni D. Nagahawatte, Recep Avci, Peng Du, Zhongming Liu, Zhongming Liu, Niranchan Paskaranandavadivel   +8 more
doaj   +1 more source

A randomized trial of deep-brain stimulation for Parkinson's disease.

New England Journal of Medicine, 2006
BACKGROUND Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management. METHODS In this randomized-pairs trial, we enrolled
G. Deuschl, C. Schade-Brittinger, P. Krack, J. Volkmann, H. Schäfer, K. Bötzel, C. Daniels, A. Deutschländer, U. Dillmann, W. Eisner, D. Gruber, W. Hamel, J. Herzog, R. Hilker, S. Klebe, M. Kloss, J. Koy, M. Krause, A. Kupsch, D. Lorenz, S. Lorenzl, H. Mehdorn, J. Moringlane, W. Oertel, M. Pinsker, H. Reichmann, A. Reuss, G. Schneider, A. Schnitzler, U. Steude, V. Sturm, L. Timmermann, V. Tronnier, T. Trottenberg, L. Wojtecki, E. Wolf, W. Poewe, J. Voges   +37 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Early differences in lassitude predicts outcomes in Stanford Neuromodulation Therapy for difficult to treat depression

npj Mental Health Research
Stanford Neuromodulation Therapy (SNT), has recently shown rapid efficacy in difficult to treat (DTT) depression. We conducted an exploratory analysis of individual symptom improvements during treatment, correlated with fMRI, to investigate this rapid ...
David Benrimoh, Azeezat Azeez, Jean-Marie Batail, Xiaoqian Xiao, Derrick Buchanan, Igor D. Bandeira, Andrew Geoly, Yaakov Keynan, Ian H. Kratter, Nolan R. Williams   +9 more
doaj   +1 more source

Estimulação magnética transcraniana em psiquiatria

Debates em Psiquiatria, 2012
Objetivo: O objetivo deste artigo foi retratar a experiência com Estimulação Magnética Transcraniana no Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina de Medicina USP (HC-FMUSP), e sua aplicação na prática clínica ...
Marco Antonio Marcolin, Hellen Livia Drumond Marra, Caio Abujadi, Carlos Gustavo Sardinha Mansur, Martin Luiz Myczkowski, Philip Leite Ribeiro, Rodrigo Lancelote Alberto, Bianca Boura Bellini   +7 more
doaj   +1 more source

Supporting Child Development Through Parenting Interventions in Low- to Middle-Income Countries: An Updated Systematic Review

Frontiers in Public Health, 2021
Background: Over 250 million children in low- and middle-income countries are at risk of not achieving their fullest developmental potential due to co-occurring risks such as poor nutrition and inadequate learning opportunities.
Linlin Zhang, Derrick Ssewanyana, Marie-Claude Martin, Stephen Lye, Greg Moran, Amina Abubakar, Kofi Marfo, Joyce Marangu, Kerrie Proulx, Tina Malti, Tina Malti   +10 more
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Lasting EEG/MEG aftereffects on human brain oscillations after rhythmic transcranial brain stimulation: Level of control over oscillatory network activity [PDF]

, 2015
A number of rhythmic protocols have emerged for non-invasive brain stimulation (NIBS) in humans, including transcranial alternating current stimulation (tACS), oscillatory transcranial direct current stimulation (otDCS) and repetitive (also called ...
Gross, Joachim, Thut, Gregor, Veniero, Domenica, Vossen, Alexandra   +3 more
core   +2 more sources