Results 71 to 80 of about 5,823,746 (333)

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Spectral and Spatial Dependence of Diffuse Optical Signals in Response to Peripheral Nerve Stimulation [PDF]

open access: yes, 2010
Using non-invasive, near-infrared spectroscopy we have previously reported optical signals measured at or around peripheral nerves in response to their stimulation.
Bergethon, Peter R.   +6 more
core   +3 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Comparative studies on yield potential of some hevea clones in Cambodia [PDF]

open access: yes, 2006
Cambodian Rubber Research Institute is carrying out researches on tapping systems to assess the influence of intensity of stimulation on yield at a given tapping frequency 1/2S d/3 7d/7. The objectives of these trials are to determine the yield potential
Chhek, Chan, Hav, S., Lacote, Régis
core  

Optimal stimulation protocol in a bistable synaptic consolidation model

open access: yes, 2018
Consolidation of synaptic changes in response to neural activity is thought to be fundamental for memory maintenance over a timescale of hours. In experiments, synaptic consolidation can be induced by repeatedly stimulating presynaptic neurons.
Gastaldi, Chiara   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Neuroplasticity associated with tactile language communication in a deaf-blind subject

open access: yesFrontiers in Human Neuroscience, 2010
A longstanding debate in cognitive neuroscience pertains to the innate nature of language development and the underlying factors that determine this faculty. We explored the neural correlates associated with language processing in a unique individual who
Souzana Obretenova   +4 more
doaj   +1 more source

Stimulation

open access: yesDefinitions, 2020
anxiety. This suggests a close relationship between the emotional and visual systems, as evidenced by their functional connections in the brain. Building upon this background, the present study focuses on investigating the effects of transcorneal ...
C. Teige   +6 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Gamma‐induction in frontotemporal dementia (GIFTeD) randomized placebo‐controlled trial: Rationale, noninvasive brain stimulation protocol, and study design

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Frontotemporal dementia (FTD) is a neurodegenerative disorder for which there is no effective pharmacological treatment. Recently, interneuron activity responsible for fast oscillatory brain activity has been found to be impaired in a mouse ...
Martina Assogna   +17 more
doaj   +1 more source

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