Results 41 to 50 of about 14,864 (256)

Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination - New Scientific-Based TCM Herbal Formulating Method -

Journal of Pharmacopuncture, 2018
Objectives:There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional “single compound, single target” approach as demonstrated in our current modern drug development.
Yean Chun Loh, Chu Shan Tan, Mun Fei Yam, Chuan Wei Oo, Wan Maznah Wan Omar   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tactile stimulations and wheel-rotation responses: Toward augmented lane departure warning systems

Frontiers in Psychology, 2014
When an on-board system detects a drift of a vehicle to the left or to the right, in what way should the information be delivered to the driver?
Christophe eTandonnet, Boris eBurle, Franck eVidal, Thierry eHasbroucq   +3 more
doaj   +1 more source

Involvement of the primary motor cortex in the early processing stage of the affective stimulus-response compatibility effect in a manikin task

NeuroImage, 2021
Compatible (positive approaching and negative avoiding) and incompatible (positive avoiding and negative approaching) behavior are of great significance for biological adaptation and survival. Previous research has found that reaction times of compatible
Xue Xia, Dandan Wang, Yuyu Song, Mengyan Zhu, Yansong Li, Robert Chen, Jian Zhang   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Activation, Inhibition, or Something Else: An Exploratory Study on Response Priming Using Moving Dots as Primes in Middle-Aged and Old Adults

Journal of Aging Research, 2018
Response priming refers to the finding that a prime stimulus preceding a target stimulus influences the response to the following target stimulus. With young subjects, using moving dot stimuli as primes indicated faster responses to compatible targets (i.
Christina Bermeitinger, Cathleen Kappes
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evidence for Two Types of Task Conflict in a Color-Digit Stroop Task

Journal of Cognition
In the present study, we conducted a Stroop-like task in which the participants were required to decide whether the presented stimulus, which could be either a colored digit or a colored rectangle, consisted of more or less than five colors.
Ronen Hershman, Eldad Keha, Ayelet Sapir, Elisabeth M. Weiss, Avishai Henik, Liane Kaufmann   +5 more
doaj   +1 more source