Results 41 to 50 of about 5,510,775 (284)

Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies [PDF]

, 2014
There has long been need for a behavioural intervention that attenuates cue-evoked drug-seeking, but the optimal method remains obscure. To address this, we report three approaches to extinguish cue-evoked drug-seeking measured in a Pavlovian to ...
Rose, Abigail K., Andrew Jones, Rose, Abigail K, Field, M, Dominic M.D. Tran, Rose, Abigail, Munafò, Marcus R., Munafo, Marcus, Joseph R. Troisi, Tran, Dominic M.D., Troisi, Joseph R, Field, Matt, Marcus R. Munafò, Lee Hogarth, Rose, AK, Munafò, Marcus R, Tran, DM, Tran, DMD, Tran, Dominic M D, Jones, Andrew, Troisi, Joseph, Troisi, Joseph R., Matt Field, Retzler, Chris, Abigail K. Rose, Munafò, MR, Chris Retzler, Hogarth, Lee, Jones, A, Troisi, JR, Hogarth, L, Tran, Dominic, Retzler, C   +32 more
core   +1 more source

Contrasting motivational orientation and evaluative coding accounts: On the need to differentiate the effectors of approach/avoidance responses

Frontiers in Psychology, 2015
Several emotion theorists suggest that valenced stimuli automatically trigger motivational orientations and thereby facilitate corresponding behavior. Positive stimuli were thought to activate approach motivational circuits which in turn primed approach ...
Julia eKozlik, Roland eNeumann, Ljubica eLozo   +2 more
doaj   +1 more source

Effect anticipation affects perceptual, cognitive, and motor phases of response preparation: evidence from an event-related potential (ERP) study

Frontiers in Human Neuroscience, 2016
The anticipation of action effects is a basic process that can be observed even for key-pressing responses in a stimulus-response paradigm. In Ziessler, Nattkemper and Vogt’s (2012) experiments participants first learned arbitrary effects of key-pressing
Neil Richard Harrison, Michael eZiessler
doaj   +1 more source

Tactile stimulations and wheel-rotation responses: Toward augmented lane departure warning systems

Frontiers in Psychology, 2014
When an on-board system detects a drift of a vehicle to the left or to the right, in what way should the information be delivered to the driver?
Christophe eTandonnet, Boris eBurle, Franck eVidal, Thierry eHasbroucq   +3 more
doaj   +1 more source

Need for space: the key distance effect depends on spatial stimulus configurations. [PDF]

PLoS ONE, 2014
In numerous psychological experiments, participants classify stimuli by pressing response keys. According to Lakens, Schneider, Jostmann, and Schubert (2011), classification performance is affected by physical distance between response keys--indicating a
Melanie Jonas, Owino Eloka, Julia Stephan, Volker H Franz   +3 more
doaj   +1 more source

Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination - New Scientific-Based TCM Herbal Formulating Method -

Journal of Pharmacopuncture, 2018
Objectives:There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional “single compound, single target” approach as demonstrated in our current modern drug development.
Yean Chun Loh, Chu Shan Tan, Mun Fei Yam, Chuan Wei Oo, Wan Maznah Wan Omar   +4 more
doaj   +1 more source

Involvement of the primary motor cortex in the early processing stage of the affective stimulus-response compatibility effect in a manikin task

NeuroImage, 2021
Compatible (positive approaching and negative avoiding) and incompatible (positive avoiding and negative approaching) behavior are of great significance for biological adaptation and survival. Previous research has found that reaction times of compatible
Xue Xia, Dandan Wang, Yuyu Song, Mengyan Zhu, Yansong Li, Robert Chen, Jian Zhang   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Short-term pre-exposure to modality mappings: Modality-incompatible single-task exposure reduces modality-specific between-task crosstalk in task-switching

Acta Psychologica, 2022
Modality compatibility refers to the similarity of the stimulus modality and the modality of the sensory-response effect that the response produces (i.e., vocal responses produce auditory effects).
Denise Nadine Stephan, Edina Fintor, Iring Koch   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source