Results 241 to 250 of about 206,921 (307)

Targeted Delivery of a Potent STING Agonist Payload via an Antibody-Drug Conjugate Drives Robust Antitumor Activity in Preclinical Models. [PDF]

Mol Cancer Ther
Gruber DR, Cummins EJ, Zeng W, Ulrich M, Smith K, Long M, Spahr K, Higgins S, Hinricher K, Langalia A, Krumm K, Olson DJ, Grogan B, Mazahreh R, Gupta P, Burke PJ, Smith A, Senter PD, Gardai SJ, Hill AG, Gray EE.   +20 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Nanomedicine leverages cuproptosis-mediated cGAS-STING activation to enhance antitumor immunity. [PDF]

J Nanobiotechnology
Li C, Li Y, Wang Z, Wang Y, Guan W, Huang Z.   +5 more
europepmc   +1 more source

Oxidized mtDNA Contributes to Pulmonary Inflammation and Fibrosis in Bleomycin-Induced Lung Injury. [PDF]

MedComm (2020)
Mao Y, Tian X, Ai J, Zhou X, Ni Y, Wan D, Luo M, Wei X.   +7 more
europepmc   +1 more source

A NIR-Ⅱ-Immunostimulatory nanoplatform rewires immunometabolism to unleash STING-driven antitumor immunity. [PDF]

J Nanobiotechnology
Yang X, Chen X, Chen M, Yang S, Wu Y, Liao H, Xia T, Shen G, Sun C, Liu L.   +9 more
europepmc   +1 more source

A photodynamically activated nanoplatform relieves glucose-driven immunosuppression to potentiate STING immunotherapy in triple-negative breast cancer. [PDF]

Mater Today Bio
Long Y, Li J, Chang M, Zhu H, Yang X, Lv Y, Sun Y, Yu Y, Zhang W.   +8 more
europepmc   +1 more source

SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING. [PDF]

J Gen Virol
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B.   +8 more
europepmc   +1 more source

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses. [PDF]

J Exp Med
Vila IK, Messaoud-Nacer Y, Taffoni C, Jardine J, Eloiflin RJ, Augereau A, Guha S, Schussler M, Le Hars P, McKellar J, Carvalho T, Postal J, Chemarin M, Re J, Guivel-Benhassine F, Lopez R, Trillet K, Barrat J, Serbier M, El Mansouri I, Luchsinger C, Chrousos GP, Porrot F, Diaz-Griffero F, Schwartz O, Blanchet FP, Majzoub K, Bidère N, Vlachakis D, Laguette N.   +29 more
europepmc   +1 more source

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Hymenoptera Stings

Clinical Techniques in Small Animal Practice, 2006
The medically important groups of Hymenoptera are the Apoidea (bees), Vespoidea (wasps, hornets, and yellow jackets), and Formicidae (ants). These insects deliver their venom by stinging their victims. Bees lose their barbed stinger after stinging and die. Wasps, hornets, and yellow jackets can sting multiple times.
Kevin T, Fitzgerald, Aryn A, Flood
openaire   +2 more sources