Results 1 to 10 of about 8,204 (252)
The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability [PDF]
Cells, 2019 Chromosomal instability (CIN) is an intricate phenomenon that is often found in human cancer, characterized by persisting errors in chromosome segregation.
Christy Hong +2 more
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cGAS is essential for cellular senescence [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Cellular senescence is important for the maintenance of tissue homeostasis. Dysregulation of senescence is linked to many human diseases, such as cancer, premature aging, and age-related diseases. Although DNA damage response has been linked to senescence, the underlying mechanism is unknown.
Junyao Ren, Hui Yang, Hanze Wang
exaly +3 more sources
Regulation of the cGAS-STING Pathway
Annual Review of ImmunologyThe cGAS-cGAMP-STING pathway is essential for immune defense against pathogens. Upon binding DNA, cGAS synthesizes cGAMP, which activates STING, leading to potent innate immune effector responses. However, lacking specific features to distinguish between self and nonself DNA, cGAS-STING immunity requires precise regulation to prevent aberrant ...
Andrea Ablasser, Pengbiao Xu
exaly +3 more sources
Virologica Sinica, 2018 The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage ...
Meiguang Xiong +3 more
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Viruses, 2020 Several DNA viruses have evolved antagonists to inhibit the cyclic GMP−AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA-sensing immune pathway.
Joshua B. Reus +4 more
doaj +1 more source
The multifaceted functions of cGAS
Journal of Molecular Cell Biology, 2022 Abstract Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a ...
Liu, Haipeng +4 more
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Nuclear cGAS: sequestration and beyond [PDF]
Protein & Cell, 2021 AbstractThe cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it ...
Juli Bai, Feng Liu
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Gut Microbes, 2021 Although cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling has been well recognized in defending DNA viruses, the role of cGAS-STING signaling in regulating infection of RNA viruses remains largely elusive.
Peifa Yu +5 more
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Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
OncoImmunology, 2020 Resiquimod (R848) and motolimod (VTX-2337) are second-generation experimental derivatives of imiquimod, an imidazoquinoline with immunostimulatory properties originally approved by the US Food and Drug Administration for the topical treatment of actinic ...
Giorgio Frega +6 more
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Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Cell Reports, 2023 Summary: Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for a healthy immune system.
Heng Lyu +6 more
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