Results 1 to 10 of about 51,941 (164)

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Nature Reviews Immunology, 2021
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the ...
Alexiane Decout, Andrea Ablasser, Shankar Venkatraman   +2 more
exaly   +2 more sources

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Cell, 2023
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of mtDNA detection by cytosolic nucleic acid sensors remain poorly defined.
Jingti Deng
exaly   +2 more sources

Regulation of the cGAS-STING Pathway

Annual Review of Immunology
The cGAS-cGAMP-STING pathway is essential for immune defense against pathogens. Upon binding DNA, cGAS synthesizes cGAMP, which activates STING, leading to potent innate immune effector responses. However, lacking specific features to distinguish between
Andrea Ablasser, Pengbiao Xu
exaly   +2 more sources

New frontiers in the cGAS-STING intracellular DNA-sensing pathway

Immunity
The cGAS-STING intracellular DNA sensing pathway has emerged as a key element of innate antiviral immunity and a promising therapeutic target. The existence of an innate immune sensor that can be activated by any double-stranded DNA of any origin raises ...
Daniel Stetson
exaly   +2 more sources

Molecular mechanisms and cellular functions of cGAS–STING signalling

Nature Reviews Molecular Cell Biology, 2020
Veit Hornung, Karl-Peter Hopfner, Hopfner Karl-Peter   +2 more
exaly   +2 more sources

Micronucleus is not a potent inducer of the cGAS/STING pathway

Life Science Alliance
The FuVis2 reporter system, designed to visualize cell nuclei harboring sister chromatid fusion, equipped with cGAS/STING reporters, offers critical insights that micronuclei are primarily captured by cGAS during mitosis but do not lead to STING ...
Yuki Sato, Makoto T Hayashi
doaj   +2 more sources

SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction

Viruses, 2020
Several DNA viruses have evolved antagonists to inhibit the cyclic GMP−AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA-sensing immune pathway.
Joshua B. Reus, Guillermo S. Trivino-Soto, Lily I. Wu, Kristiana Kokott, Efrem S. Lim   +4 more
doaj   +1 more source

cGAS–STING drives ageing-related inflammation and neurodegeneration

Nature, 2023
The cGAS–STING signalling pathway is a critical driver of chronic inflammation and functional decline during ageing, and could be targeted to halt neurodegenerative processes during old age.
M. F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland, Chong Liu, S. Glück, Vivek V. Thacker, L. Favre, Bastien Mangeat, Lona J Kroese, P. Krimpenfort, M. Prinz, A. Ablasser   +12 more
semanticscholar   +1 more source

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability

Cells, 2019
Chromosomal instability (CIN) is an intricate phenomenon that is often found in human cancer, characterized by persisting errors in chromosome segregation.
Christy Hong, Andrea E. Tijhuis, Floris Foijer   +2 more
doaj   +1 more source

cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages

Gut Microbes, 2021
Although cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling has been well recognized in defending DNA viruses, the role of cGAS-STING signaling in regulating infection of RNA viruses remains largely elusive.
Peifa Yu, Zhijiang Miao, Yang Li, Ruchi Bansal, Maikel P. Peppelenbosch, Qiuwei Pan   +5 more
doaj   +1 more source