Results 41 to 50 of about 42,468 (308)

Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation

Nature Communications, 2023
Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor, detects DNA fragments to trigger an innate immune response. Recently, accumulating evidence reveals the presence of cGAS within the nucleus. However, the biological functions
Zhengyi Zhen, Yu Chen, Haiyan Wang, Huanyin Tang, Haiping Zhang, Haipeng Liu, Ying Jiang, Zhiyong Mao   +7 more
doaj   +1 more source

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]

, 2017
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J., Cumberworth, Stephanie, Donald, Claire L., Kohl, Alain   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy

Frontiers in Bioscience-Landmark
Background: Radiotherapy is a commonly employed treatment modality for cancer; however, its radiobiological effects in hypertrophic cardiomyopathy (HCM) remain unclear.
Huiyang Li, Xin Wang, Xinping Luo, Haiming Shi, Jian Li   +4 more
doaj   +1 more source

Apoptotic caspases cut down the immunogenicity of radiation

OncoImmunology, 2019
Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon ...
Aitziber Buqué, Maria Esperanza Rodriguez-Ruiz, Jitka Fucikova, Lorenzo Galluzzi   +3 more
doaj   +1 more source

Planetary Growth with Collisional Fragmentation and Gas Drag [PDF]

, 2010
As planetary embryos grow, gravitational stirring of planetesimals by embryos strongly enhances random velocities of planetesimals and makes collisions between planetesimals destructive.
Adachi, Alexander V. Krivov, Benz, Blum, Bodenheimer, Brauer, Bromley, Chambers, Crida, Cuzzi, Desch, Gomes, Hayashi, Hidekazu Tanaka, Hiroshi Kobayashi, Ikoma, Inaba, Inaba, Inaba, Inaba, Iwasaki, Johansen, Johansen, Kenyon, Kenyon, Kenyon, Kobayashi, Kokubo, Kokubo, Kokubo, Kokubo, Kusaka, Laughlin, Levison, Makino, Mizuno, Morbidelli, Ohtsuki, Pollack, Satoshi Inaba, Stewart, Tanaka, Tanaka, Weidenschilling, Weidenschilling, Wetherill, Wetherill   +46 more
core   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Cell-free protein synthesis with technical additives – expanding the parameter space of in vitro gene expression

Beilstein Journal of Organic Chemistry
Biocatalysis has established itself as a successful tool in organic synthesis. A particularly fast technique for screening enzymes is the in vitro expression or cell-free protein synthesis (CFPS).
Tabea Bartsch, Stephan Lütz, Katrin Rosenthal   +2 more
doaj   +1 more source

Gender and Development: An Evaluation of World Bank Support, 2002-08 [PDF]

, 2010
This evaluation reviews the World Bank's progress in gender integration from 2002 through 2008. Implementation of a 2001 gender strategy was initially strong, with integration into relevant projects peaking at 64% in 2003; but it declined between 2006 ...

core  

CGAS: comparative genomic analysis server [PDF]

Bioinformatics, 2009
Abstract Summary: Comparative approach is one of the most essential methods for extracting functional and evolutionary information from genomic sequences. So far, a number of sequence comparison tools have been developed, and most are either for on-site use, requiring program installation but providing a wide variety of analyses, or for ...
Itoh, Masumi, Watanabe, Hidemi
openaire   +2 more sources