Results 61 to 70 of about 52,090 (308)

The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

JCI Insight, 2023
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward   +5 more
doaj   +1 more source

cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation

Cell Communication and Signaling
Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial infection, chronic inflammation, cancer progression and organ degeneration, but the mechanism and regulation of the ...
Jingwen Liu, Jing Zhou, Yuling Luan, Xiaoying Li, Xiangrui Meng, Wenhao Liao, Jianyuan Tang, Zheilei Wang   +7 more
semanticscholar   +1 more source

cGAS is essential for cellular senescence [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Cellular senescence is important for the maintenance of tissue homeostasis. Dysregulation of senescence is linked to many human diseases, such as cancer, premature aging, and age-related diseases. Although DNA damage response has been linked to senescence, the underlying mechanism is unknown.
Hui, Yang, Hanze, Wang, Junyao, Ren, Qi, Chen, Zhijian J, Chen   +4 more
openaire   +2 more sources

The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

Medical Review
As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING).
Zhou Zheqi, Huang Sanling, Fan Fangying, Xu Yan, Moore Casey, Li Sirui, Han Chuanhui   +6 more
doaj   +1 more source

cGAS: action in the nucleus

Frontiers in Immunology
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA damage repair, nuclear membrane repair, chromosome fusion, DNA replication, angiogenesis and other ...
Yikai Lu, Mengmeng Zhao, Li Chen, Yan Wang, Tianhao Liu, Haipeng Liu   +5 more
openaire   +3 more sources

Conjugated Metal‐Organic Frameworks on Laser‐Induced‐Graphene Scaffold Enable Picomolar Sensitivity in Electrical Biosensors

Advanced Materials Interfaces, EarlyView.
A controlled layer‐by‐layer growth process integrates conjugated metal‐organic framework thin films onto a hierarchical 3D laser‐induced graphene scaffold. When incorporated into an extended‐gate field‐effect transistor configuration, this synergistic hybrid platform achieves robust aptamer immobilization, driving highly selective, picomolar‐level ...
Khanh T. M. Le, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +2 more
wiley   +1 more source

Role and Mechanism of cGAS-STING Pathway in Cardiovascular System

Reviews in Cardiovascular Medicine
The cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system.
Xianqiang Yu, Silin Pan
doaj   +1 more source

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Cell Death and Disease, 2023
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan   +17 more
doaj   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis

Nature
Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS–STING-mediated signalling and tumour suppression1–3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given ...
Min-Guk Cho, Rashmi J. Kumar, Chien-Chu Lin, J. Boyer, Jamshaid A. Shahir, K. Fagan-Solis, Dennis A. Simpson, Cheng Fan, Christine E. Foster, A. Goddard, Lynn M. Lerner, Simon W. Ellington, Qinhong Wang, Ying Wang, Alice Y. Ho, Pengda Liu, C. Perou, Qi Zhang, R. McGinty, Jeremy E. Purvis, Gaorav P. Gupta   +20 more
semanticscholar   +1 more source