Results 61 to 70 of about 42,468 (308)
Neural Regeneration ResearchInflammation plays a key role in driving the secondary brain injury that follows ischemic stroke. Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.
Qian Li +9 more
doaj +1 more source
An API for IPv6 Multihoming based on HBA and CGA [PDF]
, 2005 EUNICE 2005. IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6–8 July, 2005. (Proceedings of the 11th Open European Summer School EUNICE 2005: Networked Applications)This paper proposes an API for Multihoming in IPv6 ...
Bagnulo Braun, Marcelo Gabriel +2 more
core +2 more sources
The polyphenolic and hydroxycinnamate contents of whole coffee fruits from China, India and Mexico [PDF]
, 2013 Air dried whole coffee fruits, beans and husks from China, India and Mexico were analysed for their chlorogenic acids (CGA), caffeine, and polyphenolic content. Analysis was by HPLC and Orbitrap exact mass spectrometry.
Combet, E. +4 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang +13 more
wiley +1 more source
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]
, 2019 STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju +6 more
core +1 more source
Prevailing dust-transport directions on comet 67P/Churyumov-Gerasimenko
, 2015 Dust transport and deposition behind larger boulders on the comet 67P/Churyumov-Gerasimenko (67P/C-G) have been observed by the Rosetta mission. We present a mechanism for dust transport vectors based on a homogenous surface activity model incorporating ...
Kramer, Tobias, Noack, Matthias
core +1 more source
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges
Medical ReviewAs a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING).
Zhou Zheqi +6 more
doaj +1 more source
Role and Mechanism of cGAS-STING Pathway in Cardiovascular System
Reviews in Cardiovascular MedicineThe cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system.
Xianqiang Yu, Silin Pan
doaj +1 more source