Results 71 to 80 of about 42,468 (308)

A Multiphase Model for the Intracluster Medium [PDF]

, 1999
Constraints on the clustered mass density \Omega_m of the universe derived from the mean intracluster gas fraction of X-ray clusters may be biased by a single-phase assumption for the thermodynamic structure of the intracluster medium (ICM). We propose a
A. E. Evrard, Birkinshaw M., Cavaliere A., Cen R., Cole S., D. Nagai, David L. P., Eke V. R., Fabian A. C., Frenk C. S., Gunn K. F., Hamuy M., Inagaki Y., Irwin J. A., Irwin J. A., Jones M., M. E. Sulkanen, Mohr J. J., Navarro J. F., Neumann D. M., Nulsen P. E. J., Peres C. B., Raymond J. C., Riess A. G., Thomas P., Thomas P. A., White D. A., White S. D. M., Zaroubi S.   +28 more
core   +3 more sources

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

JCI Insight, 2023
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward   +5 more
doaj   +1 more source

Efficient security for IPv6 multihoming [PDF]

, 2005
In this note, we propose a security mechanism for protecting IPv6 networks from possible abuses caused by the malicious usage of a multihoming protocol.
Azcorra Saloña, Arturo, Bagnulo Braun, Marcelo Gabriel, García Martínez, Alberto   +2 more
core   +5 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

On the Transferability of Knowledge among Vehicle Routing Problems by using Cellular Evolutionary Multitasking

, 2020
Multitasking optimization is a recently introduced paradigm, focused on the simultaneous solving of multiple optimization problem instances (tasks). The goal of multitasking environments is to dynamically exploit existing complementarities and synergies ...
Del Ser, Javier, Laña, Ibai, Lobo, Jesus L., Martinez, Aritz D., Osaba, Eneko   +4 more
core   +1 more source

Nanoelectromechanical Resonator Arrays for Ultrafast, Gas-Phase Chromatographic Chemical Analysis [PDF]

, 2010
Miniaturized gas chromatography (GC) systems can provide fast, quantitative analysis of chemical vapors in an ultrasmall package. We describe a chemical sensor technology based on resonant nanoelectromechanical systems (NEMS) mass detectors that provides
Aldridge, S. J., Lewis, N. S., Li, Mo, McCaig, H. C., Myers, E. B., Roukes, M. L., Simonson, R. J., Tang, H. X., Whiting, J. J.   +8 more
core   +2 more sources

Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS

PLOS Pathogens, 2020
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics resulting in predominantly symptomatic infections, which in rare cases cause long term debilitating arthritis and arthralgia. Significant progress has been made in understanding the roles of canonical RNA sensing pathways in the host recognition of CHIKV; however, less is
L. G. Webb, J. Veloz, J. Pintado-Silva, T. Zhu, M. V. Rangel, T. Mutetwa, L. Zhang, D. Bernal-Rubio, D. Figueroa, L. Carrau, R. Fenutria, U. Potla, St. P. Reid, J. S. Yount, K. A. Stapleford, S. Aguirre, A. Fernandez-Sesma   +16 more
openaire   +4 more sources

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source