Results 71 to 80 of about 8,204 (252)

cGAS NLS2 부위의 새로운 기능

, 2020
Cyclic GMP-AMP synthase (cGAS) recognizes double-stranded DNA exposed to cells by extracellular or internal stress and activates the innate immune system. Although the main intracellular localization of cGAS is widely known as the cytosol, there has been
김, 의연
core   +1 more source

Role and Mechanism of cGAS-STING Pathway in Cardiovascular System

Reviews in Cardiovascular Medicine
The cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system.
Xianqiang Yu, Silin Pan
doaj   +1 more source

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Cell Death and Disease, 2023
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan   +17 more
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

BRD4 inhibition stimulates DDR-dependent cGAS activation.

, 2020
(a) Co-localization of cGAS with cytosolic DNA was assessed with immunofluorescence in cGAS-EGFP transfected NIH/3T3 cells treated with DMSO and JQ-1 (1 μM) for 24 h. Scale bar, 10 μm.
Hong-Tao Wu (8616984), Xiang-Dong Li (2389804), Lei Zeng (254605), Sheng-Li Ming (8616975), Bing-Qian Su (8616981), Yong-Kun Du (8616996), Li-Juan Shi (8616978), Guo-Yu Yang (1728175), Zhong-Hu Liu (8616990), Bei-Bei Chu (8617002), Guo-Li Li (8616972), Chun-Feng Wang (6185558), Ying-Qian Han (8616987), Da-Wei Jiang (8616993), Jiang Wang (14683), Gai-Ping Zhang (8616999)   +15 more
core   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Protein & Cell, 2020
The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading
Mi Li, Hong-Bing Shu
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Structural mechanism of cGAS inhibition by the nucleosome [PDF]

, 2020
The DNA sensor cGAS initiates innate immune responses following microbial infection, cellular stress, and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2’3’ cyclic GMP-AMP and triggers inflammatory cytokine and type I ...
Weiss, Joscha, Melenec, Pauline, Thomä, Nicolas H., Nicolas H. Thomä, Guey, Baptiste, Georg Kempf, Makasheva, Kristina, Zuzanna Kozicka, Ganesh R. Pathare, Pathare, Ganesh R., Kempf, Georg, Baptiste Guey, Kozicka, Zuzanna, Kristina Makasheva, Beat Fierz, Selene Glück, Andrea Ablasser, Glück, Selene, Simone Cavadini, Ruud Hovius, Fierz, Beat, Joscha Weiss, Ablasser, Andrea, Alexiane Decout, Cavadini, Simone, Pauline Melenec, Decout, Alexiane, Hovius, Ruud   +27 more
core   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source